| 1. |
- Eriksson, Mikael, 1977-
(författare)
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The complex internationalization process unfolded : The case of Atlas Copco’s entry into the Chinese mid-market
- 2016
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Despite its contemporary relevance, we still have limited empirical knowledge about the forces underlying complex internationalization processes as when multinational corporations (MNCs) seek to enter new growing markets. Based on a real-time process study comprising ninety interviews and two hundred hours of observation made between 2009 and 2012, Atlas Copco’s entry into the Chinese mid-market was investigated. The intra-organizational analysis showed that three inter-related processes were underlying Atlas’ market entry and the results suggest that multiple interrelated motors may drive many contemporary internationalization processes. The processes identified are a sequential strategy process, an evolutionary process which shows that routines changed, and a political process. A somewhat surprising finding is that the main driver of internationalization according to received theory, the firm’s accumulated experiences, not only can drive internationalization, but may also hamper MNC managers’ possibilities to enter many of today’s new and growing markets. The findings add to our knowledge of the internationalization process in an increasingly complex international business setting, and especially highlight the need to distinguish between the sequential strategy process – more in line with received theory – and the other processes, in order to get a more full-fledged picture of what internationalization in large MNCs is all about.
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| 2. |
- Felix, Janine F, et al.
(författare)
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Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.
- 2016
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Ingår i: Human molecular genetics. - : Oxford University Press (OUP). - 1460-2083 .- 0964-6906. ; 25:2, s. 389-403
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Tidskriftsartikel (refereegranskat)abstract
- A large number of genetic loci are associated with adult body mass index. However, the genetics of childhood body mass index are largely unknown. We performed a meta-analysis of genome-wide association studies of childhood body mass index, using sex- and age-adjusted standard deviation scores. We included 35 668 children from 20 studies in the discovery phase and 11 873 children from 13 studies in the replication phase. In total, 15 loci reached genome-wide significance (P-value < 5 × 10(-8)) in the joint discovery and replication analysis, of which 12 are previously identified loci in or close to ADCY3, GNPDA2, TMEM18, SEC16B, FAIM2, FTO, TFAP2B, TNNI3K, MC4R, GPR61, LMX1B and OLFM4 associated with adult body mass index or childhood obesity. We identified three novel loci: rs13253111 near ELP3, rs8092503 near RAB27B and rs13387838 near ADAM23. Per additional risk allele, body mass index increased 0.04 Standard Deviation Score (SDS) [Standard Error (SE) 0.007], 0.05 SDS (SE 0.008) and 0.14 SDS (SE 0.025), for rs13253111, rs8092503 and rs13387838, respectively. A genetic risk score combining all 15 SNPs showed that each additional average risk allele was associated with a 0.073 SDS (SE 0.011, P-value = 3.12 × 10(-10)) increase in childhood body mass index in a population of 1955 children. This risk score explained 2% of the variance in childhood body mass index. This study highlights the shared genetic background between childhood and adult body mass index and adds three novel loci. These loci likely represent age-related differences in strength of the associations with body mass index.
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| 3. |
- Jäderkvist Fegraeus, Kim, et al.
(författare)
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Gaitedness is associated with the DMRT3 'Gait keeper' mutation in Morgan and American Curly horses
- 2014
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Ingår i: Animal Genetics. - : Wiley. - 0268-9146 .- 1365-2052. ; 45, s. 908-909
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Annan publikation (refereegranskat)abstract
- The nonsense mutation in the DMRT3 gene is known to affect locomotion pattern and gait ability in horses[1] and performance of Standardbred and Nordic trotters.[1, 2] The mutation (a change from cytosine, C, to adenine, A) has been found in all tested gaited breeds and in breeds used for harness racing, whereas it is absent in most of the three-gaited breeds, such as the Swedish Warmblood and Thoroughbreds.[3] Previous studies have shown that the mutation is strongly associated with horses' ability to perform alternate gaits.[1, 3, 4] In the study by Promerová etal.,[3] breeds with a frequency of the mutation at 50% or higher were classified as either gaited or breeds used for harness racing. There are many different types of alternate gaits, for example foxtrot, running walk, tölt and pace.[3] In this study, we investigated if there is a connection between the genotype in DMRT3 and gaitedness in Morgan and American Curly horses. Previous study showed that the frequency of the mutated A allele in these breeds was 14.0% and 16.7% respectively.[3]
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| 4. |
- Jäderkvist Fegraeus, Kim, et al.
(författare)
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The importance of the DMRT3 'Gait keeper' mutation on riding traits and gaits in Standardbred and Icelandic horses
- 2015
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Ingår i: Livestock Science. - : Elsevier BV. - 1871-1413 .- 1878-0490. ; 176, s. 33-39
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Tidskriftsartikel (refereegranskat)abstract
- Previous studies have shown that a single base-pair mutation, a change from cytosine (C) to adenine (A), in the DMRT3 gene affects both the ability to show ambling and lateral gaits in a wide range of horse breeds, as well as racing performance and trotting technique in Standardbred and Nordic trotters. The variant allele is present in gaited breeds but is absent, or found at a very low frequency, in breeds used for Western-European style riding and flat racing, like the Swedish Warmblood and Thoroughbreds as well as in draught horses. This indicates that the variant allele might have a negative effect on certain riding performance traits in horses. Therefore, one aim of this study was to investigate whether the DMRT3 variant affects canter in Standardbred trotters, and to test if heterozygous horses (CA) were better suited for Western-European style riding than homozygous horses (M). Riding traits were studied in 115 Standardbred horses, and a similar study was also performed with data from 55 Nordic trotters. The results showed that CA Standardbreds had significantly better balance in canter, both collected and extended canter, than M horses. The CA horses also got significantly higher scores for transitions in collected canter. For the rhythm we found no significant differences between the genotypes. In the Nordic trotters we were unable to establish any significant difference for canter ability. Another aim of this study was to investigate the effect of the variant allele on riding abilities and gaits in the Icelandic horse (n=446). Practically all horse breeds considered to be three-gaited have a CC genotype, in contrast Icelandic CC horses can show tolt We therefore tested whether the variant influenced how difficult it was to initiate tolt training for these horses. It was also investigated whether the variant affects which gaits Icelandic horses choose, both at liberty and during initial training. Icelandic CC horses were significantly more difficult to train to tolt compared to CA and AA horses. The M Icelandic horses showed the lateral gaits tolt and pace significantly more frequent, both at liberty and during initial training, than CA or CC horses. The majority of the Icelandic CC and CA horses chose trot at liberty and during initial training.
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| 5. |
- Kanoni, Stavroula, et al.
(författare)
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Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
- 2022
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Ingår i: Genome biology. - : Springer Science and Business Media LLC. - 1474-760X .- 1465-6906 .- 1474-7596. ; 23:1
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Tidskriftsartikel (refereegranskat)abstract
- Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery.To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N=1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism.Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.
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| 6. |
- Vogelezang, Suzanne, et al.
(författare)
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Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits.
- 2020
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Ingår i: PLoS genetics. - : Public Library of Science (PLoS). - 1553-7404. ; 16:10
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Tidskriftsartikel (refereegranskat)abstract
- The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (Rg ranging from 0.11 to 0.76, P-values <0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood.
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| 7. |
- Wong, Grace, et al.
(författare)
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The making of resource frontier spaces in the Congo Basin and Southeast Asia : A critical analysis of narratives, actors and drivers in the scientific literature
- 2022
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Ingår i: World development perspectives. - : Elsevier BV. - 2452-2929. ; 27
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Tidskriftsartikel (refereegranskat)abstract
- Forest frontiers are rapidly changing to sites of commodity agriculture throughout the tropics, with far-reaching transformations in landscapes and livelihoods. Many of the dynamics that drive frontier commodification are well-rehearsed since colonial times. Policies to deregulate markets, privatize or formalize land tenure and open borders to trade have stimulated resource exploitation. The accompanying territorial interventions such as new enclosures, reconfigured property regimes and claims are purposefully employed to create space and labor, and have radically reconfigured the relationships of millions of people to land and rule. Narratives of what is an opportunity for whom, who should benefit from these spaces, and what is a problem in need of a solution have shaped policies and development choices in frontiers over time. Science plays a critical role, by putting forward particular knowledge and understandings, contributing to problematisations and promoting or legitimating certain solutions. In this paper, we review how science has portrayed forest frontiers in the Congo Basin and Southeast Asia. We analyse storylines put forward in the scientific literature and find three dominant narratives that intersect and reinforce each other to legitimate colonial exploitation of forest and land resources, and the enactment of colonial forest and land codes that have laid a deep-seated path in post-colonial policies. The narratives focus on imaginings of frontier regions as spaces that are idle or empty, and where possibilities for extraction, conservation and development appear unlimited; the problematization of smallholder and shifting cultivation farming as practices in need of change; and the legitimation of capitalist and market-based rationales as solutions. We find these narratives to be largely similar across both the Congo Basin and Southeast Asia and persistent in contemporary policies and global development strategies. This analysis allows for a deeper understanding of how commodification of frontiers came about, and what role science can play for a more just development.
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