| 1. |
- Blomquist, Christine, et al.
(författare)
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Lärande och ledning i komplexa beslutsprocesser
- 2002
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Ingår i: Ledarskapets olika skepnader. - Lund : Studentlitteratur. - 914402181X ; , s. 143-154, s. 143-154
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 2. |
- Holmberg, Per, 1964, et al.
(författare)
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Systemisk-funktionell lingvistik. Att analysera språkets betydelsepotential
- 2014
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Ingår i: Folkmålsstudier. - 0356-1771. ; 52, s. 9-30
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Tidskriftsartikel (refereegranskat)abstract
- This article presents the theory of Systemic functional linguistics (SFL), first developed by Michael Halliday, and exemplifies how the theory can be applied in empirical analysis of text and talk. It shows how SFL is centered on the idea that language functions in social meaning making, and how this idea is theoretically elaborated in terms of stratification, metafunctional diversity, systemic choices and registers. The article includes a theoretical description of these four central notions, followed by a presentation of two empirical studies. Both studies explore lexicogrammatical and semantic choices within the ideational metafunction, though in different registers. The first study is an analysis of the use of grammatical metaphor in text written by monolingual and multilingual upper secondary school students. Grammatical metaphor is the realization of meaning in atypical, or incongruent, ways. In the study, grammatical metaphor is a developmental trait, allowing students to express specialized meanings through new combinations between semantics and lexicogrammar. In the second analysis SFL is applied on talk in interaction and combined with activity analysis. The study explores the successive instantiation of the meaning potential of language in a certain context, namely when participants talk about thinking in radio phone-in counseling conversations. An analysis within the ideational metafunction combined with the notion of communicative projects describes how, in this specific case, the participants’ lexicogrammatical choices between a verb and a nominal form contributes in a critical way to a successful outcome of the ongoing counseling activity.
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| 3. |
- Koinberg, Ingalill, 1955-, et al.
(författare)
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Breast cancer patients' satisfaction with a spontaneous system of check-up visits to a specialist nurse
- 2002
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Ingår i: Scandinavian Journal of Caring Sciences. - Oxford : Wiley. - 0283-9318 .- 1471-6712. ; 16:3, s. 209-215
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Tidskriftsartikel (refereegranskat)abstract
- Aim: To describe breast cancer patients' satisfaction with a spontaneous system of check-up visits to a specialist nurse.Background: There is little evidence that routine follow-up visits after breast cancer surgery influence survival or patient satisfaction. Consequently, there is a need to evaluate alternative follow-up programmes.Sample: A strategic sample of 19 breast cancer patients, who were not involved in a routine follow-up system but who had the possibility of contacting a specialist nurse when necessary, were interviewed.Method: A qualitative descriptive design inspired by the method of phenomenographic analysis was used.Findings: Five description categories and 606 statements showing similarities and differences in conceptions were obtained. The patients satisfaction with the knowledgeable and professional skills of the nurses was high. Confirmation and trust were important and necessary in order for the women with breast cancer to feel secure. Patients had a need for information and self-care education . Accessibility and early assessment by professional personnel or an oncology nurse were essential in a system without routine follow-ups.Discussion: This study identifies key issues in a specialist nurse-led check-up system. The findings can be used for developing an education programme for women who have undergone breast cancer surgery. Additionally, the findings emphasize the need to introduce more flexible solutions to the follow-up programmes, one alternative being specialist nurse-led check-ups.
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| 4. |
- Koinberg, Inga-Lill, 1955-, et al.
(författare)
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Nurse-led follow-up on demand or by a physician after breast cancer surgery : A randomised study
- 2004
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Ingår i: European Journal of Oncology Nursing. - London : Churchill Livingstone. - 1462-3889 .- 1532-2122. ; 8:2, s. 109-117
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Tidskriftsartikel (refereegranskat)abstract
- The value of routine follow-up with frequent visits to a breast cancer specialist - both in terms of detection of recurrence and patient satisfaction - has been questioned. The aim of this study was to compare nurse-ted follow-up on demand versus physician follow-up after breast cancer treatment with regards to patients’ well-being, satisfaction, access to medical care and medical safety. Two hundred and sixty-four consecutively selected women with newly diagnosed breast cancer, classified as UICC stage I or stage II, were randomised to follow-up at two hospitals in Sweden, either by routine medical follow-up, the physician group (PG, n = 131), or on demand by a specialist nurse, the nurse group (NG, n = 133). Measures were done at baseline and twice a year over a period of 5 years by means of a questionnaire containing the Hospital Anxiety and Depression Scale (HAD), and the Satisfaction and Accessibility (SaaC) scale. Number of contacts with the health care services, number of diagnostic procedures, and time to recurrence or death were monitored. The ratings of HAD and SaaC did not show any statistically significant differences between the groups. The levels of anxiety and depression were generally low and levels of patient satisfaction high. There were no differences between the groups concerning time to recurrence or death. This study indicates that women with breast cancer in stages I to II can be followed up by a specialist nurse with high patient satisfaction and good medical safety. © 2004 Published by Elsevier Ltd.
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| 5. |
- Koinberg, Inga-Lill, et al.
(författare)
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Satisfaction with routine follow-up visits to the physician : The needs of patients with breast cancer
- 2001
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Ingår i: Acta Oncologica. - : Informa UK Limited. - 0284-186X .- 1651-226X. ; 40:4, s. 454-459
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Tidskriftsartikel (refereegranskat)abstract
- Follow-up visits after surgery for breast cancer constitute a large proportion of the outpatient consultations at surgical and oncological clinics. The reasons for the follow-ups include early detection of relapse, patients' well-being, and data collection for quality assurance and scientific studies. The aim of this study was to describe the needs of the patient with breast cancer and satisfaction with routine follow-up visits to the physician. A strategic sample of 20 women with breast cancer, routinely followed-up at an oncology outpatient clinic, was interviewed. A qualitative descriptive design inspired by the phenomenographic method was used. The results identified the need for routines, accessibility, security, continuity, confidence and information. The women's views demonstrated that there are strong reasons for reviewing and changing the design of the traditional follow-up system to obtain the most effective and well-functioning system possible to better meet these women's needs.
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| 6. |
- Koinberg, Inga-Lill, et al.
(författare)
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The usefulness of a multidisciplinary educational programme after breast cancer surgery : A prospective and comparative study
- 2006
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Ingår i: European Journal of Oncology Nursing. - London : Elsevier. - 1462-3889 .- 1532-2122. ; 10, s. 273-82
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Tidskriftsartikel (refereegranskat)abstract
- The aim of the study was to compare and evaluate a multidisciplinary educational programme with traditional follow-up visits to a physician after breast cancer surgery in terms of well-being, aspects of self-care and coping ability 1 year after diagnosis. A reduction in the intensity of follow-up after breast cancer surgery is recommended. New follow-up models are being debated and could be of interest. The study design was non-randomised and comparative. Ninety-six consecutively selected women with newly diagnosed breast cancer, classified as stage I or stage II, participated in either a multidisciplinary educational programme (n = 5 0), or traditional follow-up by a physician (n = 4 6). Three questionnaires were used: Functional Assessment of Cancer Therapy-General (FACT-G), a study specific questionnaire regarding self-care aspects (SCA) and Sense of Coherence (SOC). With the exception of physical well-being at baseline there was no significant difference between the groups. The women in the multidisciplinary educational programme increased their physical and functional well-being (P < 0.0 1). The women in traditional follow-up by a physician increased their functional well-being while social/family well-being (P < 0.0 1) decreased over time. There was a statistically significant difference in SOC (P < 0.0 0 1) in the traditional follow-up by a physician between baseline (mean=74.4, SD=12.4) and the 1-year follow up (mean=67.7, SD=11.4). Thus, women in the traditional follow-up by a physician scored lower in the area of SOC 1 year after diagnosis. A multidisciplinary educational programme may be an alternative to traditional follow-up by a physician after breast cancer surgery, but more research is needed about the financial benefits and effectiveness of such a programme.
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| 7. |
- Wikström, Ingela, 1974-
(författare)
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Molecular genetics of B- and T-lymphocyte development
- 2006
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Lymphocytes are essential for the generation of specific immunity. Development of B cells in the bone marrow and T cells in the thymus have several analogous features, and are tightly regulated processes. Even though there is an increasing amount of information concerning lymphopoiesis, a lot of questions remain. The aim of this thesis has been to understand some of the molecular events that contribute to the control of lymphocyte development.Expression of the B cell receptor is an important checkpoint in B lymphocyte development. The Dµ protein is a truncated B cell receptor that can induce some of the signals elicited by full length µ, but cannot promote further B cell differentiation. In order to determine if this could stem from an impaired survival signal, we introduced Bcl-2 into RAG2 deficient Dµ transgenic mice. Analysis of these mice showed that Dµ could not support pre-B cell maturation despite extended survival of B cell precursors by Bcl-2. In addition, data from recombination competent Dµ transgenic mice demonstrated that the Dµ induced partial block is permissive for marginal zone B cell development, whereas the formation of follicular B cells is severely reduced.The bHLH family of transcription factors is known to be involved in the regulation of lymphocyte development. Whereas the roles of E2A and HEB have been well documented in both B- and T-lymphocytes, detailed knowledge concerning E2-2 is lacking. To address the role of E2-2 in B cell development, we have reconstituted mice, using E2-2 deficient fetal liver cells, and analysed the B cell compartments. We also measured mRNA expression patterns for the three E-proteins in wildtype mice. Resulting data show that, in addition to a role in B cell lineage entry, E2-2 is required for efficient expansion of pro-B cells, and also influences the follicular versus marginal zone decision.While focusing on assigning a role for E2-2 in T-cell development, we analyzed the expression of the E-proteins during this process and performed functional studies in fetal thymic organ cultures. E2-2 deficient mouse embryos were shown to display a partial block at the DN3 stage, which was not due to proliferation or apoptosis defects. In addition, analysis of expression levels of the pre-Talpha chain suggests that E2-2 may play a role in the regulation of transcription of pre-Talpha, and therefore in the assembly of the pre-T cell receptor.
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