| 1. |
- Coombes, R C, et al.
(författare)
-
Survival and safety of exemestane versus tamoxifen after 2-3 years' tamoxifen treatment (Intergroup Exemestane Study): a randomised controlled trial.
- 2007
-
Ingår i: Lancet. - 1474-547X. ; 369:9561, s. 559-70
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Early improvements in disease-free survival have been noted when an aromatase inhibitor is given either instead of or sequentially after tamoxifen in postmenopausal women with oestrogen-receptor-positive early breast cancer. However, little information exists on the long-term effects of aromatase inhibitors after treatment, and whether these early improvements lead to real gains in survival. METHODS: 4724 postmenopausal patients with unilateral invasive, oestrogen-receptor-positive or oestrogen-receptor-unknown breast cancer who were disease-free on 2-3 years of tamoxifen, were randomly assigned to switch to exemestane (n=2352) or to continue tamoxifen (n=2372) for the remainder of a 5-year endocrine treatment period. The primary endpoint was disease-free survival; overall survival was a secondary endpoint. Efficacy analyses were intention-to-treat. This study is registered as an International Standard Randomised Controlled Trial, number ISRCTN11883920. RESULTS: After a median follow-up of 55.7 months (range 0-89.7), 809 events contributing to the analysis of disease-free survival had been reported (354 exemestane, 455 tamoxifen); unadjusted hazard ratio 0.76 (95% CI 0.66-0.88, p=0.0001) in favour of exemestane, absolute benefit 3.3% (95% CI 1.6-4.9) by end of treatment (ie, 2.5 years after randomisation). 222 deaths occurred in the exemestane group compared with 261 deaths in the tamoxifen group; unadjusted hazard ratio 0.85 (95% CI 0.71-1.02, p=0.08), 0.83 (0.69-1.00, p=0.05) when 122 patients with oestrogen-receptor-negative disease were excluded. CONCLUSIONS: Our results suggest that early improvements in disease-free survival noted in patients who switch to exemestane after 2-3 years on tamoxifen persist after treatment, and translate into a modest improvement in overall survival.
|
|
| 2. |
- Asproth, Viveca, 1948-, et al.
(författare)
-
Anticipatory Modeling and Simulation for Inter-Regional Security
- 2012
-
Ingår i: The 21st European Meeting on Cybernetics and Systems Research.
-
Konferensbidrag (refereegranskat)abstract
- The idea of anticipatory modeling and simulation with subsequent learning from the outcomes is here applied on inter regional security work. In this setting, multiactors have to both cooperate and make coordinated decisions with just partial information about each other. With help of netAgora, a net based environment for simulation, learning, and communication, the goal of training, preparedness and continuous improvement of decisions is met.
|
|
| 3. |
- Asproth, Viveca, et al.
(författare)
-
Applying Anticipatory Computing in System Dynamics
- 2001
-
Ingår i: Computing anticipatory systems. - Melville, N.Y : American Institute of Physics. - 0735400121 ; , s. 578-589
-
Konferensbidrag (refereegranskat)abstract
- A traditional System Dynamics Model is compared with an Anticipatory Soft Computing Approach. A system for control and management of water resources and hydro electrical power stations is used as a real world test case. The System Dynamics Model is easily developed and run with help of commercial, special purpose modelling and simulation software. The resulting model increases understanding and generates new insights. Its lack of anticipatory power, however, makes the control task difficult. With the anticipatory approach, on the other hand, the control becomes more effective even if the modelling and model complexity increases rapidly than applied on a reasonable big and realistic real world case. Strong Anticipation, as compared to the more traditional Weak Anticipation, has proved itself to have many interesting and powerful properties.
|
|
| 4. |
- Asproth, Viveca, et al.
(författare)
-
Creative Anticipatory Spatial Modelling for Intra Regional Simulation
- 2004
-
Ingår i: COMPUTING ANTICIPATORY SYSTEMS. - Mellville, N.Y : American Institute of Physics. - 0735401985 ; , s. 533-543
-
Konferensbidrag (refereegranskat)abstract
- Current models and tools for support in spatial intra regional design, planning, and management may generally be judged as being too descriptive and too reactive. Hence, due to their rigidity and focusing on system history, they have severe shortcomings in guiding decision-makers in current decision situations, which are characterized by increasingly high degrees of uncertainty, unperceptibility, and change. Therefore, in order to improve the conditions for decision-makers, a conceptual design of a new tool, the MAP-tool, for support in such work is presented. MAP is designed around the conceptual integration of anticipatory modelling and computing, multi modal system modelling, soft computing, and spatial modelling and computing
|
|
| 5. |
- Asproth, Viveca, 1948-, et al.
(författare)
-
Debriefing with R-statistics and support for System Dynamics Modeling of Inter Regional Security
- 2013
-
Ingår i: Proceedings of IADIS International Conference e-Society 2013. - : IADIS Press.
-
Konferensbidrag (refereegranskat)abstract
- This paper presents data from an emergency management exercise conducted in May 2011 with participants from emergency teams in Norway and Sweden. Software was developed specifically for the tabletop exercise in which a web-based presentation of the events of the emergency scenario allowed detailed recording of the communication among the teams both within and between the two countries. The communication messages were used to analyze who communicated with whom, how often and with what kind of information about the emergency event. The R-statistics open source package allowed analysis of the data for the debriefing session following the training session. A social network analysis model is planned as input to a system dynamics model. Data from 13 discrete events in the tabletop simulation will provide input to the system dynamics model in order to visualize communication patterns between emergency teams both within each country and across the border.
|
|
| 6. |
- Asproth, Viveca, et al.
(författare)
-
Multi modal anticipation in fuzzy space
- 2006
-
Ingår i: AIP Conference Proceedings. - New York : American Institute of Physics. - 0735403317 ; , s. 442-452
-
Konferensbidrag (refereegranskat)abstract
- We are all stakeholders in the geographical space, which makes up our common living and activity space. This means that a careful, creative, and anticipatory planning, design, and management of that space will be of paramount importance for our sustained life on earth. Here it is shown that the quality of such planning could be significantly increased with help of a computer based modelling and simulation support tool. Further, the design and implementation of such a tool ought to be guided by the conceptual integration of some core concepts like anticipation and retardation, multi modal system modelling, fuzzy space modelling and simulation, and multi actor interaction.
|
|
| 7. |
- Asproth, Viveca, 1948-, et al.
(författare)
-
NLS: The NetAgoraLearning System
- 2013
-
Ingår i: Advances in Simulation-Based Decision Support & Business Intelligence. ; 3, s. 11-15
-
Tidskriftsartikel (refereegranskat)
|
|
| 8. |
- Asproth, Viveca, et al.
(författare)
-
Rapport från GSS : Gränsöverskridande samarbete för säkerhet
- 2014
-
Rapport (populärvet., debatt m.m.)abstract
- Projektet Gränsöverbryggande Samverkan för Säkerhet (GSS) har syftat till att bidra till ökad säkerhet, och därmed också ökad livskvalitet, såväl för den befolkning som stadigvarande bor i gränslandet som de besökare som tillfälligt vistas i området. I detta syfte ligger också ökade möjligheter att rädda liv och hälsa samt att begränsa skador på miljö och materiella (ekonomiska) tillgångar. GSS fokuserar på den information och kunskap, som krävs i en räddnings-och krissituation. GSS sätter förberedelsearbetet i främsta rummet.Projektets gränsöverskridande mervärde har flera dimensioner:•Det ökar förståelse, tillit och samarbete mellan säkerhetsansvariga på ömse sidor nationsgränsen.•Myndigheter med säkerhetsansvar etablerar långsiktiga institutionella samarbeten runt säkerhet och krishantering.•Gränsregionens attraktionskraft ökar tack vare ökad säkerhet och förbättrad krishanteringsförmåga.•Den ömsesidiga kunskapen och förståelsen om förhållanden på andra sidan nationsgränsen ökar hos projektdeltagarna.Projektet har genomförts i form av tre årliga cykler bestående av scenarioskapande, ledningsövning och utvärdering. Resultatet från utvärderingarna har sedan legat till grund för nästa års cykel. Parallellt med detta har ettövningssystem utvecklats. Systemet innehåller scenariobank, övningar och stöd för dessa, play-backfunktion samt utvärderingsmodul inklusive statistikfunktioner. Utvärderingarna från övningarna finns i separat bilaga. Den första övningen genomfördes som en tabletop-övning vid Gränsräddningsrådets möte 2011. De två andra övningarna genomfördes så att deltagarna satt på sina respektive arbetsplatser och kunde kommunicera med varandra, dels via traditionella kommunikationsmedel, dels med hjälp av övningssystemet. Dessa övningar diskuterades sedan vid Gränsräddningsrådets möten.I framtagande av scenarios och övningar har personer från de verksamheter som skulle öva deltagit. Erfarenheterna från projektet är att behovet av övningar av det här slaget är stort. De deltagande organisationerna uttrycket att det varit mycket lärorikt att delta och man har skaffat sig nya kontakter och/eller utvecklat de kontakter man redan haft. Det har också visat sig att man haft direkt nytta av projektet vid verkliga händelser.Projektets kostnader har upplöpt till ca 3,2 mill. SEK och knappt 2,5 mill. NOK. Kostnader har huvudsakligen bestått i arbetstid och i någon mån av resor. Resekostnaden har minskat genom att projektet frekvent använt sig av distansteknik i stället för fysiska möten.
|
|
| 9. |
|
|
| 10. |
- Asproth, Viveca, 1948-, et al.
(författare)
-
Simulated Decision Learning in a Multiactor Setting
- 2010
-
Ingår i: Organizacija. - : Walter de Gruyter GmbH. - 1318-5454 .- 1581-1832. ; 43:3, s. 136-145
-
Tidskriftsartikel (refereegranskat)abstract
- The idea of decision analysis-and subsequent learning from the outcomes-is old within Operational Research. Here this approach to continuous improvement of decision outcomes is put one step further within the area of crisis and disaster management. This is done by introducing multiactors making simultaneous decisions with just partial information about each other. Further, decision outcomes are achieved from a simulation model rather than from the real object system.
|
|
