| 1. |
- Lund, Johan, et al.
(författare)
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Lenalidomide versus lenalidomide plus dexamethasone prolonged treatment after second-line lenalidomide plus dexamethasone induction in multiple myeloma
- 2018
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Ingår i: Cancer Medicine. - : WILEY. - 2045-7634. ; 7:6, s. 2256-2268
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Tidskriftsartikel (refereegranskat)abstract
- Lenalidomide (Len) plus dexamethasone (Dex) is approved for the treatment of relapsed or refractory multiple myeloma (RRMM). It is possible that single-agent Len may be effective as prolonged treatment regimen in RRMM once patients demonstrate an initial response to Len+Dex induction. Patients with RRMM who responded to first-line Len+Dex in an observational study (NCT01430546) received up to 24 cycles of either Len (25mg/day) or Len+Dex (25mg/day and 40mg/week) as prolonged treatment in a subsequent phase 2 clinical trial (NCT01450215). In the observational study (N = 133), median time to response was 1.7 (range 0.6-9.6) months. A complete response to all treatments received in both studies was observed in 11% of patients; very good partial response and partial response rates were 31% and 38%, respectively. Corresponding response rates in the subgroup of patients who did not enter the phase 2 trial (n = 71) were 3%, 18%, and 39%, respectively. Rates of disease progression at 2years in the phase 2 trial were 47% versus 31% for Len versus Len+Dex (P = 0.14). After 36months median follow-up in surviving patients, median time to progression was not reached with Len+Dex and was 24.9months (95% confidence interval 12.5-not calculable, P amp;lt; 0.001) with Len. Three-year OS among the total observational study population was 61% (95% CI, 52-69%). The corresponding rate among patients who entered the phase 2 clinical trial was 73% (95% CI, 60-83%) and was significantly lower among those patients who achieved PR but did not proceed into the phase 2 trial (55%; P = 0.01). In the phase 2 trial, OS was 73% in both treatment arms (P = 0.70). Neutropenia and thrombocytopenia were more common with prolonged (phase 2 trial) versus short-term (observational study) Len administration but remained manageable. Prolonged treatment with Len with or without Dex provides sustained, clinically relevant responses and demonstrates an acceptable safety profile.
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| 2. |
- Byttner, Stefan, 1975-, et al.
(författare)
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An ion current algorithm for fast determination of high combustion variability
- 2004
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Ingår i: SAE Technical Paper Series. - 400 Commonwealth Drive, Warrendale, PA, United States : SAE International. - 0148-7191.
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Konferensbidrag (refereegranskat)abstract
- It is desirable for an engine control system to maintain a stable combustion. A high combustion variability (typically measured by the relative variations in produced work, COV(IMEP)) can indicate the use of too much EGR or a too lean air-fuel mixture, which results in less engine efficiency(in terms of fuel and emissions) and reduced driveability. The coefficient of variation (COV) of the ion current integral has previously been shown in several papers to be correlated to the coefficient of variation of IMEP for various disturbances (e.g. AFR, EGR and fuel timing). This paper presents a cycle-to-cycle ion current based method of estimating the approximate category of IMEP (either normal burn, slow burn, partial burn or misfire) for the case of lean air-fuel ratio. The rate of appearance of the partial burn and misfire categories is then shown to be well correlated with the onset of high combustion variability(high COV(IMEP)). It is demonstrated that the detection of these categories can result in faster determination(prediction) of high variability compared to only using the COV(Ion integral). Copyright © 2004 SAE International.
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| 3. |
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| 4. |
- Hellring, Magnus, et al.
(författare)
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A Comparison of Ion Current Based Algorithms for Peak Pressure Position Control
- 2001
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Ingår i: SAE technical paper series. - Warrendale, PA : Society of Automobile Engineers. - 0148-7191.
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Tidskriftsartikel (refereegranskat)abstract
- Combustion timing control of SI engines can be improved by feedback of the peak pressure position (PPP). However, pressure sensors are costly, and therefore, nonintrusive and cheap ion-current ’soft sensors’ have been suggested. Three different algorithms have been proposed that extract information about PPP from the ion current signal. In this paper, these approaches are compared with respect to accuracy, operational range, implementation aspects, as well as sensitivity to engine load and inlet air humidity. Copyright © 2001 Society of Automotive Engineers, Inc.
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| 5. |
- Hellring, Magnus, et al.
(författare)
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An ion current based peak-finding algorithm for pressure peak position estimation
- 2000
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Ingår i: SAE technical paper series. - Warrendale, PA : Society of Automobile Engineers. - 0148-7191.
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Tidskriftsartikel (refereegranskat)abstract
- In this paper a novel ion current based estimation scheme for the in-cylinder pressure peak position (PPP) is proposed. A reliable estimate is constructed by appropriate signal processing based on local curvatures of the post flame phase of the ion current. The peak-finding algorithm is simple and easy to implement in an engine control unit for feedback control of the combustion phasing. Results on real data, sampled onboard a commercial car are presented. Further, the performance of the algorithm is compared to two state of the art algorithms for PPP estimation from the ion current. The comparison shows that the algorithm presented in this paper outperforms its competitors. Copyright © 2000 Society of Automotive Engineers, Inc.
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| 6. |
- Holmberg, Ulf, 1959-, et al.
(författare)
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A pneumatic loudspeaker for intensive sounds
- 2001
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Ingår i: ECC : 2001 European Control Conference. - New York, NY : Institute of Electrical and Electronics Engineers (IEEE). - 9783952417362 ; , s. 2257-2260
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Konferensbidrag (refereegranskat)abstract
- A pneumatic loudspeaker for intensive sounds is presented. It operates by modulation of air from over- and underpressure reservoirs, as opposed to siren-like loudspeakers that use compressed air only. The symmetric construction makes the behavior more linear both with respect to aperture amplitudes and frequency bandwidth. Therefore, it may be used as secondary source in industrial active noise control problems where generation of large volume velocities are necessary. It is also shown that a Hammerstein model can model the loudspeaker over a wide frequency band. © 2001 EUCA.
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| 7. |
- Holmberg, Ulf, 1959-, et al.
(författare)
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A pole-projection approach to robust control design
- 2015
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Konferensbidrag (refereegranskat)abstract
- A pole-projection approach is proposed as a useful tool for multi-objective robust control design. Different load conditions or nonlinearities are considered in the design by simultaneously stabilizing a set of linear models. The idea is to repeatedly project the poles for each model (one at a time) to a generalized stability region until all models are stabilized. Similarly, pole projections are also performed for an auxiliary set of models. Stability of the latter gives guaranteed bounds on different sensitivity functions for the former. The method solves a benchmark problem for which a controller of lower complexity than has been reported before is obtained. © 1999 EUCA.
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| 8. |
- Lidström, Kristoffer, 1981-, et al.
(författare)
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A Modular CACC System Integration Design
- 2012
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Ingår i: IEEE transactions on intelligent transportation systems (Print). - Piscataway : IEEE Press. - 1524-9050 .- 1558-0016. ; 13:3, s. 1050-
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Tidskriftsartikel (refereegranskat)abstract
- This paper describes the Halmstad University entry in the GrCooperative Driving Challenge, which is a competition in vehicle platooning. Cooperative platooning has the potential to improve traffic flow by mitigating shock wave effects, which otherwise may occur in dense traffic. A longitudinal controller that uses information exchanged via wireless communication with other cooperative vehicles to achieve string-stable platooning is developed. The controller is integrated into a production vehicle, together with a positioning system, communication system, human€“machine interface (HMI). A highly modular system architecture enabled rapid development testing of the various subsystems. In the competition, which took place in May 2011 on a closed-off highway in The Netherlands, the Halmstad University team finished second among nine competing teams._x000D_
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| 9. |
- Skytte af Sätra, Ulf, 1959-
(författare)
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Wear of piston rings in hydrostatic transmissions
- 2005
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This study focuses on the wear of piston rings in a hydraulic radial piston motor. The piston ring has to satisfy increasing demands for reliability and longer service life. It has two contacting surfaces, the face and the flank, and operates under a boundary lubrication state. This first part of the project aimed to detect and characterise piston ring wear. Measurement by weighing gives an overall value for wear defined as loss of mass. Two-dimensional form and surface roughness measurements show the distribution of wear on the piston ring face in contact with the cylinder bore and the piston ring flank in contact with the piston groove. Three-dimensional analyses, both quantitative and qualitative, allow the wear mechanisms to be identified. The wear of piston rings from an actual hydraulic motor was characterised. As well, rig testing was performed in two different test rig set-ups, one simulating the sliding movement of the piston ring and the other the tilting movement at the end of the strokes. Wear during the running-in period was investigated, and the findings indicate that the period when this takes place is of short duration. In the long term, mild wear makes the surfaces smoother than they were when new, resulting in a very low wear coefficient. Significant levels of wear were measured on both contacting surfaces of the piston ring. In cases in which the flank exhibits more wear than the face, the wear on the flank can be reduced by proper design of the piston groove. The second part of the project aimed to evaluate use of a textured surface for the cylinder bore counter surface and a coated surface for the piston ring. Three modelling experiments were performed to characterise the friction and wear properties under lean boundary lubrication conditions. Under such conditions, textured surfaces have the advantage of retaining more lubricant and supplying it over a longer time. Stable friction was also a distinctive feature of the textured surface. Use of a coating could also possibly reduce the amount of wear. Though a smooth surface, like a polished one, is hard to beat for a working texture, a coated surface is far ahead of a smooth uncoated one. Different manufactured and commonly used cylinder bore surfaces, including textured ones, were evaluated in the sliding movement test rig. That allowed favourable wear properties, such as lowest wear coefficient, to be determined with the use of a roller burnished surface. A final part of the research involved simulating wear on the piston ring face throughout the entire service life of a hydraulic motor. This allowed us to determine the roles of surface roughness and coating in prolonging service life and achieving acceptable and secure piston ring operation. The model is simple and realistic, but still needs to be refined so as to correspond even better to reality.
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| 10. |
- Svensson, Wolfgang, 1969-, et al.
(författare)
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An Autonomous Control System for a Prosthetic Foot Ankle
- 2006
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Ingår i: 4th IFAC Symposium on Mechatronic Systems (2006). - : International Federation of Automatic Control (IFAC). - 9783902661173 ; , s. 856-861
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Konferensbidrag (refereegranskat)abstract
- When walking on inclined ground the biological foot adjusts the ankle angle accordingly. Prosthetic foot users have often a limited range of motion in their ankle which makes walking on hills uncomfortable. This paper describes a system which can autonomously correct the ankle angle to the inclination. The ground angle is estimated using an accelerometer. The angle foot blade to heel is then adjusted with a DC-motor. Since the controller only activates the motor when the foot is lifted and thus not loaded, a small powered system can be used.
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