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| 2. |
- Delfani, Payam, et al.
(författare)
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Technical advances of the recombinant antibody microarray technology platform for clinical immunoproteomics
- 2016
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 11:7
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Tidskriftsartikel (refereegranskat)abstract
- In the quest for deciphering disease-associated biomarkers, high-performing tools for multiplexed protein expression profiling of crude clinical samples will be crucial. Affinity proteomics, mainly represented by antibody-based microarrays, have during recent years been established as a proteomic tool providing unique opportunities for parallelized protein expression profiling. But despite the progress, several main technical features and assay procedures remains to be (fully) resolved. Among these issues, the handling of protein microarray data, i.e. the biostatistics parts, is one of the key features to solve. In this study, we have therefore further optimized, validated, and standardized our in-house designed recombinant antibody microarray technology platform. To this end, we addressed the main remaining technical issues (e.g. antibody quality, array production, sample labelling, and selected assay conditions) and most importantly key biostatistics subjects (e.g. array data pre-processing and biomarker panel condensation). This represents one of the first antibody array studies in which these key biostatistics subjects have been studied in detail. Here, we thus present the next generation of the recombinant antibody microarray technology platform designed for clinical immunoproteomics.
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| 3. |
- Gillis, Carole, et al.
(författare)
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SI and the Lund experience
- 2012
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Ingår i: Students, the university ́s unspent resource: revolutionising higher education through active student participation. ; , s. 45-60
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 4. |
- Hansson, Per
(creator_code:cre_t)
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BLOOD TREATMENT APPARATUS WITH FLOW DIVIDER FOR LIMITING AN ELECTRICAL CURRENT
- 2015
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Patent (övrigt vetenskapligt/konstnärligt)abstract
- A blood treatment apparatus (2) comprising: a blood treatment unit (10); a blood line (20) configured to extract blood from a blood source (21), pass the blood through the blood treatment unit (10) and deliver treated blood to a target vessel (22); and a fluid line (30) configured pass treatment fluid through the blood treatment unit (10) and deliver used treatment fluid to a fluid sink (32). A flow divider (40) is arranged in the fluid line (30) separates treatment fluid into to a first fluid section (51) and a second fluid section (53), thereby electrically isolating the fluid sections (51, 53) such that electrical current flowing in the fluid line (30) between the fluid sections (51, 53) is limited. Related manufacturing and verification methods are also described.
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| 5. |
- Hertz, Thomas
(creator_code:cre_t)
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Blood treatment apparatus adapted to preserve parts thereof
- 2015
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Patent (övrigt vetenskapligt/konstnärligt)abstract
- A blood treatment apparatus adapted to preserve a blood treatment unit (20) between blood treatment sessions. The blood treatment apparatus is configured to i) perform a blood treatment session and thereby use the blood treatment unit (20), ii) fill the blood treatment unit (20) with a preservation fluid comprising at least one treatment fluid concentrate of a type that is used to prepare the treatment fluid, iii) maintain the preservation fluid in the blood treatment unit (20) until a next blood treatment session is prepared, iv) dispatch the preservation fluid from the blood treatment unit (20) in preparation of a next blood treatment session, and v) perform a next blood treatment session and thereby extend the use of the blood treatment unit (20). A related method is also described.
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| 6. |
- Holmer, Emil, 1983-, et al.
(författare)
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Facial mimicry interference reduces working memory accuracy for facial emotion expressions
- 2024
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Ingår i: PLOS ONE. - 1932-6203. ; 19:6, s. e0306113-e0306113
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Tidskriftsartikel (refereegranskat)abstract
- Facial mimicry, the tendency to imitate facial expressions of other individuals, has been shown to play a critical role in the processing of emotion expressions. At the same time, there is evidence suggesting that its role might change when the cognitive demands of the situation increase. In such situations, understanding another person is dependent on working memory. However, whether facial mimicry influences working memory representations for facial emotion expressions is not fully understood. In the present study, we experimentally interfered with facial mimicry by using established behavioral procedures, and investigated how this interference influenced working memory recall for facial emotion expressions. Healthy, young adults (N = 36) performed an emotion expression n-back paradigm with two levels of working memory load, low (1-back) and high (2-back), and three levels of mimicry interference: high, low, and no interference. Results showed that, after controlling for block order and individual differences in the perceived valence and arousal of the stimuli, the high level of mimicry interference impaired accuracy when working memory load was low (1-back) but, unexpectedly, not when load was high (2-back). Working memory load had a detrimental effect on performance in all three mimicry conditions. We conclude that facial mimicry might support working memory for emotion expressions when task load is low, but that the supporting effect possibly is reduced when the task becomes more cognitively challenging.
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| 7. |
- Holmer, Mattias
(creator_code:cre_t)
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Blood treatment apparatus and method
- 2013
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Patent (övrigt vetenskapligt/konstnärligt)abstract
- A proposed blood treatment apparatus includes: a blood treatment unit (D), a pair of fluid pumps (PF1, PF2) and a pair of blood pumps (PB1, PB2). The blood treatment unit (D) is configured to receive untreated blood and fresh blood treatment fluid, and emit treated blood and used blood treatment fluid. The fluid pumps (PF1, PF2) are configured to pass blood treatment fluid through the blood treatment unit (D). The blood pumps (PB1, PB2) are configured to extract untreated blood from a blood source ( BS), pass extracted blood through the blood treatment unit (D) and deliver treated blood to a target vessel (BT). Flow measurement means (Q1, Q2, P) determines at least one blood f low parameter ( BQFI) reflecting an average flow in relation to the blood treatment unit (D) during a well-defined period of operation (T) of the apparatus, for example while completing one operation cycle.; The at least one blood flow parameter (BQFI) is determined based on a difference between (i) a first amount (DMI) of fresh blood treatment fluid received into the blood treatment unit (D), and (ii) a second amount (DMO) of used blood treatment fluid emitted from the blood treatment unit (D) during another well-defined period (Ta).
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| 8. |
- Holmer, Mattias
(creator_code:cre_t)
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Detecting blood path disruption in extracorporeal blood processing
- 2015
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Patent (övrigt vetenskapligt/konstnärligt)abstract
- A device monitors a blood path from a blood vessel access of a human subject through an extracorporeal blood processing apparatus and back to the blood vessel access. A pumping device in the blood path is operable to pump blood through the blood path from the blood withdrawal device to the blood return device. The monitoring device obtains pressure data from a pressure sensor arranged upstream of the pumping device in the blood path, and processes the pressure data for detection of a disruption of the blood path downstream of the pumping device, e.g. caused by VND (Venous Needle Dislodgement). The disruption is detected by evaluating presence/absence of cross-talk pulses at the pressure sensor, where the cross-talk pulses originate from one or more pulse generators in the extracorporeal blood processing apparatus and have propagated on a propagation path in a direction downstream of the pumping device through the blood return device, the blood vessel access and the blood withdrawal device to the pressure sensor.
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| 9. |
- Holmer, Mattias, et al.
(författare)
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Detection of Needle Dislodgement Using Extracorporeal Pressure Signals : A Feasibility Study
- 2020
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Ingår i: ASAIO Journal. - 1538-943X. ; 66:4, s. 454-462
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Tidskriftsartikel (refereegranskat)abstract
- Venous needle dislodgement (VND) during dialysis is a rarely occurring adverse event, which becomes life-threatening if not handled promptly. Because the standard venous pressure alarm, implemented in most dialysis machines, has low sensitivity, a novel approach using extracted cardiac information to detect needle dislodgement is proposed. Four features are extracted from the arterial and venous pressure signals of the dialysis machine, characterizing the mean venous pressure, the venous cardiac pulse pressure, the time delay, and the correlation between the two pressure signals. The features serve as input to a support vector machine (SVM), which determines whether dislodgement has occurred. The SVM is first trained on a set of laboratory data, and then tested on another set of laboratory data as well as on a small data set from clinical hemodialysis sessions. The results show that dislodgement can be detected after 12-17 s, corresponding to 24-143 ml blood loss. The standard venous pressure alarm used in clinical routine only detects 50% of the VNDs, whereas the novel method detects all VNDs and has a false alarm rate of 0.12 per hour, provided that the amplitude of the extracted cardiac pressure signal exceeds 1 mmHg. The results are promising; however, the method needs to be tested on a larger set of clinical data to better establish its performance.
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| 10. |
- Holmer, Mattias, et al.
(författare)
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Detection of ventricular premature beats based on the pressure signals of a hemodialysis machine
- 2018
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Ingår i: Medical Engineering and Physics. - : Elsevier BV. - 1350-4533. ; 51, s. 49-55
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Tidskriftsartikel (refereegranskat)abstract
- Monitoring of ventricular premature beats (VPBs), being abundant in hemodialysis patients, can provide information on cardiovascular instability and electrolyte imbalance. In this paper, we describe a method for VPB detection which explores the signals acquired from the arterial and the venous pressure sensors, located in the extracorporeal blood circuit of a hemodialysis machine. The pressure signals are mainly composed of a pump component and a cardiac component. The cardiac component, severely overshadowed by the pump component, is estimated from the pressure signals using an earlier described iterative method. A set of simple features is extracted, and linear discriminant analysis is performed to classify beats as either normal or ventricular premature. Performance is evaluated on signals from nine hemodialysis treatments, using leave-one-out crossvalidation. The simultaneously recorded and annotated photoplethysmographic signal serves as the reference signal, with a total of 149,686 normal beats and 3574 VPBs. The results show that VPBs can be reliably detected, quantified by a Youden's J statistic of 0.9, for average cardiac pulse pressures exceeding 1 mmHg; for lower pressures, the J statistic drops to 0.55. It is concluded that the cardiac pressure signal is suitable for VPB detection, provided that the average cardiac pulse pressure exceeds 1 mmHg.
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