| 1. |
- Hultin, Sara, et al.
(författare)
-
AmotL2 links VE-cadherin to contractile actin fibres necessary for aortic lumen expansion
- 2014
-
Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 5
-
Tidskriftsartikel (refereegranskat)abstract
- The assembly of individual endothelial cells into multicellular tubes is a complex morphogenetic event in vascular development. Extracellular matrix cues and cell-cell junctional communication are fundamental to tube formation. Together they determine the shape of endothelial cells and the tubular structures that they ultimately form. Little is known regarding how mechanical signals are transmitted between cells to control cell shape changes during morphogenesis. Here we provide evidence that the scaffold protein amotL2 is needed for aortic vessel lumen expansion. Using gene inactivation strategies in zebrafish, mouse and endothelial cell culture systems, we show that amotL2 associates to the VE-cadherin adhesion complex where it couples adherens junctions to contractile actin fibres. Inactivation of amotL2 dissociates VE-cadherin from cytoskeletal tensile forces that affect endothelial cell shape. We propose that the VE-cadherin/amotL2 complex is responsible for transmitting mechanical force between endothelial cells for the coordination of cellular morphogenesis consistent with aortic lumen expansion and function.
|
|
| 2. |
- Åsman, Barbro, et al.
(författare)
-
A Search for New Physics in Dijet Mass and Angular Distributions in 36 pb$^{-1}$ of $pp$ Collisions at $\sqrt{s}=7$ TeV Measured with the ATLAS Detector
- 2011
-
Ingår i: New Journal of Physics. - : IOP Publishing. - 1367-2630. ; 13, s. 053044-
-
Tidskriftsartikel (refereegranskat)abstract
- A search for new interactions and resonances produced in LHC proton-proton (pp) collisions at a centre-of-mass energy root s = 7 TeV was performed with the ATLAS detector. Using a dataset with an integrated luminosity of 36 pb(-1), dijet mass and angular distributions were measured up to dijet masses of similar to 3.5 TeV and were found to be in good agreement with Standard Model predictions. This analysis sets limits at 95% CL on various models for new physics: an excited quark is excluded for mass between 0.60 and 2.64 TeV, an axigluon hypothesis is excluded for axigluon masses between 0.60 and 2.10 TeV and quantum black holes are excluded in models with six extra space-time dimensions for quantum gravity scales between 0.75 and 3.67 TeV. Production cross section limits as a function of dijet mass are set using a simplified Gaussian signal model to facilitate comparisons with other hypotheses. Analysis of the dijet angular distribution using a novel technique simultaneously employing the dijet mass excludes quark contact interactions with a compositeness scale 3 below 9.5 TeV.
|
|
| 3. |
- Åsman, Barbro, et al.
(författare)
-
Measurement of the $W\to\ell\nu$ and $Z/gamma^\ast\to\ell\ell$ Production Cross Sections in Proton-Proton Collisions at $\sqrt{s}=7$ TeV with the ATLAS Detector
- 2010
-
Ingår i: Journal of High Energy Physics (JHEP). - 1126-6708 .- 1029-8479. ; :12, s. 060-
-
Tidskriftsartikel (refereegranskat)abstract
- First measurements of the W → ℓν and Z/γ * → ℓℓ (ℓ = e, μ) production cross sections in proton-proton collisions at Ös = 7 \textTeV s=7TeV are presented using data recorded by the ATLAS experiment at the LHC. The results are based on 2250 W → ℓν and 179 Z/γ * → ℓℓ candidate events selected from a data set corresponding to an integrated luminosity of approximately 320 nb. The measured total W and Z/γ ∗-boson production cross sections times the respective leptonic branching ratios for the combined electron and muon channels are sW\texttot Wtot. BR(W → ℓν) = 9.96 ± 0.23(stat) ± 0.50(syst) ± 1.10(lumi) nb and sZ / g \texttot totZ BR(Z/γ ∗ → ℓℓ) = 0.82 ± 0.06 (stat) ± 0.05 (syst) ± 0.09(lumi) nb (within the invariant mass window 66 < m ℓℓ < 116GeV). The W/Z cross-section ratio is measured to be 11.7 ± 0.9(stat) ± 0.4(syst). In addition, measurements of the W + and W − production cross sections and of the lepton charge asymmetry are reported. Theoretical predictions based on NNLO QCD calculations are found to agree with the measurements
|
|
| 4. |
- Åsman, Barbro, et al.
(författare)
-
Search for the Standard Model Higgs boson in the decay channel H -> ZZ((*)) -> 4l with 4.8 fb(-1) of pp collision data at root s=7 TeV with ATLAS
- 2012
-
Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 710:3, s. 383-402
-
Tidskriftsartikel (refereegranskat)abstract
- This Letter presents a search for the Standard Model Higgs boson in the decay channel H -> ZZ((*)) -> l(+)l(-)l(-)+l(')-, where l,l' = e or mu, using proton-proton collisions at root s = 7 TeV recorded with the ATLAS detector and corresponding to an integrated luminosity of 4.8 fb(-1). The four-lepton invariant mass distribution is compared with Standard Model background expectations to derive upper limits on the cross section of a Standard Model Higgs boson with a mass between 110 GeV and 600 GeV. The mass ranges 134-156 GeV, 182-233 GeV, 256-265 GeV and 268-415 GeV are excluded at the 95% confidence level. The largest upward deviations from the background-only hypothesis are observed for Higgs boson masses of 125 GeV, 244 GeV and 500 GeV with local significances of 2.1, 2.2 and 2.1 standard deviations, respectively. Once the look-elsewhere effect is considered, none of these excesses are significant.
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
|
|
