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Sökning: WFRF:(Holmquist M)

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  • Maxwell, Tania L., et al. (författare)
  • Global dataset of soil organic carbon in tidal marshes
  • 2023
  • Ingår i: Scientific Data. - : Springer Nature. - 2052-4463. ; 10:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Tidal marshes store large amounts of organic carbon in their soils. Field data quantifying soil organic carbon (SOC) stocks provide an important resource for researchers, natural resource managers, and policy-makers working towards the protection, restoration, and valuation of these ecosystems. We collated a global dataset of tidal marsh soil organic carbon (MarSOC) from 99 studies that includes location, soil depth, site name, dry bulk density, SOC, and/or soil organic matter (SOM). The MarSOC dataset includes 17,454 data points from 2,329 unique locations, and 29 countries. We generated a general transfer function for the conversion of SOM to SOC. Using this data we estimated a median (± median absolute deviation) value of 79.2 ± 38.1 Mg SOC ha−1 in the top 30 cm and 231 ± 134 Mg SOC ha−1 in the top 1 m of tidal marsh soils globally. This data can serve as a basis for future work, and may contribute to incorporation of tidal marsh ecosystems into climate change mitigation and adaptation strategies and policies.
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  • Ahmed, Nur, et al. (författare)
  • Impact of climate change on rice insect pests and their natural enemies
  • 2013
  • Konferensbidrag (refereegranskat)abstract
    • Rice is one of the important staple foods for half of the world population particularly Asian countries for their livelihood, socio-economic and nutrition. Global warming is predicted to increase frequency of precipitation/rainfall, intensity of drought and solar-radiation/UV-B radiation which might affect the intensity and severity of rice pests in one hand, but also change in other friendly arthropods on the other hand. The present studies discuss the influence of climatic factors (temperature and rainfall) on yellow stem borer (YSB), brown planthopper (BPH), green leafhopper (GLH) and their natural enemies (spider, lady bird beetle, green mirid bug). Light trap and sweep net catches of arthropods from different rice habitats were used in this study. For GLH there is a strong periodicity at 6 months and a somewhat weaker periodicity at 12 months followed by an even weaker periodicity at 3 months, especially valid for both methods of data collection (light trap and sweep-net data). Finally, for GMB there is a strong periodicity at 6 months and a somewhat weaker periodicity at 3 months followed by an even weaker periodicity at 4 months. There is a general increasing trend over the ten years seems to be present in the GLH. This corresponds to that the abundance in 2005 is generally 15 times larger than in January 1996. For LBB, there is an increasing trend of log abundance of LBB over time and shows a strong periodicity at 3 months and a somewhat weaker periodicity at 4 months followed by an even weaker periodicity at about 6 months. For Spider there is a strong periodicity at 2.4 months and a somewhat weaker periodicity at 4 months followed by an even weaker periodicities at about 3 months and 6 months. Results show an increase of maximum temperature of approximately 0.5 to 1°C over 10 years.
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  • Chagtai, Tasnim, et al. (författare)
  • Gain of 1q as a prognostic biomarker in Wilms Tumors (WTs) treated with preoperative chemotherapy in the International Society of Paediatric Oncology (SIOP) WT 2001 trial : A SIOP renal tumours biology consortium study
  • 2016
  • Ingår i: Journal of Clinical Oncology. - 0732-183X. ; 34:26, s. 3195-3203
  • Tidskriftsartikel (refereegranskat)abstract
    • Purpose: Wilms tumor (WT) is the most common pediatric renal tumor. Treatment planning under International Society of Paediatric Oncology (SIOP) protocols is based on staging and histologic assessment of response to preoperative chemotherapy. Despite high overall survival (OS), many relapses occur in patients without specific risk factors, and many successfully treated patients are exposed to treatments with significant risks of late effects. To investigate whether molecular biomarkers could improve risk stratification, we assessed 1q status and other potential copy number biomarkers in a large WT series. Materials and Methods: WT nephrectomy samples from 586 SIOP WT 2001 patients were analyzed using a multiplex ligation-dependent probe amplification (MLPA) assay that measured the copy number of 1q and other regions of interest. Results: One hundred sixty-seven (28%) of 586 WTs had 1q gain. Five-year event-free survival (EFS) was 75.0% in patients with 1q gain (95% CI, 68.5% to 82.0%) and 88.2% in patients without gain (95% CI, 85.0% to 91.4%). OS was 88.4% with gain (95% CI, 83.5% to 93.6%) and 94.4% without gain (95% CI, 92.1% to 96.7%). In univariable analysis, 1q gain was associated with poorer EFS (P < .001; hazard ratio, 2.33) and OS (P = .01; hazard ratio, 2.16). The association of 1q gain with poorer EFS retained significance in multivariable analysis adjusted for 1p and 16q loss, sex, stage, age, and histologic risk group. Gain of 1q remained associated with poorer EFS in tumor subsets limited to either intermediate-risk localized disease or nonanaplastic localized disease. Other notable aberrations associated with poorer EFS included MYCN gain and TP53 loss. Conclusion: Gain of 1q is a potentially valuable prognostic biomarker in WT, in addition to histologic response to preoperative chemotherapy and tumor stage.
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  • Gallego-Sala, Angela V., et al. (författare)
  • Latitudinal limits to the predicted increase of the peatland carbon sink with warming
  • 2018
  • Ingår i: Nature Climate Change. - : Springer Science and Business Media LLC. - 1758-678X .- 1758-6798. ; 8:10, s. 907-
  • Tidskriftsartikel (refereegranskat)abstract
    • The carbon sink potential of peatlands depends on the balance of carbon uptake by plants and microbial decomposition. The rates of both these processes will increase with warming but it remains unclear which will dominate the global peatland response. Here we examine the global relationship between peatland carbon accumulation rates during the last millennium and planetary-scale climate space. A positive relationship is found between carbon accumulation and cumulative photosynthetically active radiation during the growing season for mid- to high-latitude peatlands in both hemispheres. However, this relationship reverses at lower latitudes, suggesting that carbon accumulation is lower under the warmest climate regimes. Projections under Representative Concentration Pathway (RCP)2.6 and RCP8.5 scenarios indicate that the present-day global sink will increase slightly until around AD 2100 but decline thereafter. Peatlands will remain a carbon sink in the future, but their response to warming switches from a negative to a positive climate feedback (decreased carbon sink with warming) at the end of the twenty-first century.
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  • Holmquist, Lars Erik, et al. (författare)
  • Building Intelligent Environments with Smart-Its
  • 2004
  • Ingår i: IEEE Computer Graphics and Applications. - 0272-1716 .- 1558-1756. ; 24:1, s. 56-64
  • Tidskriftsartikel (refereegranskat)abstract
    • The development of Smart-Its for building smart environments is discussed. Smart-Its are small, self-contained, stick-on computers that attach to everyday objects. These augmented objects become soft media, enabling dynamic digital relationships with users and each other. A Smart-Its consists of a core board with a wireless transceiver to let the device communicate with other Smart-Its, plus a sensor board that gives the Smart-Its data about its sorroundings. The major advantage of the system is that it allows designers and researchers to construct responsive or intelligent environments.
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  • HOLMQUIST, M, et al. (författare)
  • TRP89 IN THE LID OF HUMICOLA-LANUGINOSA LIPASE IS IMPORTANT FOR EFFICIENT HYDROLYSIS OF TRIBUTYRIN
  • 1994
  • Ingår i: Lipids. - : Wiley. - 0024-4201 .- 1558-9307. ; 29:9, s. 599-603
  • Tidskriftsartikel (refereegranskat)abstract
    • To determine whether Trp89 located in the lid of the lipase (EC 3.1.1.3) from Humicola lanuginosa is important for the catalytic property of the enzyme, site-directed mutagenesis at Trp89 was carried out. The kinetic properties of wild type and mutated enzymes were studied with tributyrin as substrate. Lipase variants in which Trp89 was changed to Phe, Leu, Gly or Glu all showed less than 14% of the activity compared to that of the wild type lipase. The Trp89Glu mutant was the least active with only 1% of the activity seen with the wild type enzyme. Ah Trp mutants had the same binding affinity to the tributyrin substrate interface as did the wild type enzyme. Wild type lipase showed saturation kinetics against tributyrin when activities were measured with mixed emulsions containing different proportions of tributyrin and the nonionic alkyl polyoxyethylene ether surfactant, Triton DF-16. Wild type enzyme showed a V-max = 6000 +/- 300 mmol.min(-1).g(-1) and an apparent K-m = 16 +/- 2% (vol/vol) for tributyrin in Triton DF-16, while the mutants did not show saturation kinetics in an identical assay. The apparent K-m for tributyrin in Triton DF-16 was increased as the result of replacing Trp89 with other residues (Phe, Leu, Gly or Glu). The activities of all mutants were more sensitive to the presence of Triton DF-16 in the tributyrin substrate than was wild type lipase. The activity of the Trp89Glu mutant was decreased to 50% in the presence of 2 vol% Triton DF-16 compared to the activity seen with pure tributyrin as substrate. Wild type lipase and all mutants except Trp89Glu had the same affinity for the substrate interface formed by 15.6 vol% tributyrin in Triton DF-16. The Trp89Glu mutant showed a lower affinity than all the other lipase variants for the interface of 15.6 vol% tributyrin in Triton DF-16. The study showed that Trp89 located in the lid of H. lanuginosa lipase is important for the efficient hydrolysis of tributyrin and that this residue plays a role in the catalytic steps after adsorption of the lipase to the substrate interface.
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  • Kjellstrand, Per, et al. (författare)
  • Effects of methylene chloride on body and organ weight and plasma buturylcholinesterase activity in mice
  • 1986
  • Ingår i: Acta Pharmacologica et Toxicologica. - : Wiley. - 0001-6683. ; 59:1, s. 73-79
  • Tidskriftsartikel (refereegranskat)abstract
    • Exposure to methylene chloride produced a time and concentration related increase in liver weight. The effect was more prominent in female mice than in male. The activity of plasma butyrylcholinesterase (BuChE) increased even more than the liver weight at corresponding exposures, but only in the males. Fatty infiltration was noticeable after exposure to 75 p.p.m. and was more prominent in the females than in the males. Thirty to 60 days of continuous exposure were required to reach stable maxima. Intermittent exposure was less effective than continuous exposure in producing the effects. Most effects were fully reversible after exposure for both 30 and 90 days if the animals were transferred to a solvent-free environment. However, after exposure for 90 days, BuChE activity in the males did not return to normal within 30 days but after 90 and 120 days free from exposure only slight if any effects on BuChE activity remained.
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