↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Träfflista för sökning "WFRF:(Horsnell J) "

Sökning: WFRF:(Horsnell J)

Resultat 1-3 av 3

Sortera/gruppera träfflistan

Sortering: Träffar per sida:

Numrering	Referens	Omslagsbild	Hitta
1.	2021 swepub:Mat__t
2.	Glasbey, JC, et al. (författare) 2021 swepub:Mat__t
3.	Lopez-Cervantes, J. P., et al. (författare) Parental TB associated with offspring asthma and rhinitis 2022 Ingår i: The International Journal of Tuberculosis and Lung Disease. - Paris, France : International Union Against Tuberculosis and Lung Disease. - 1027-3719 .- 1815-7920. ; 26:6, s. 544-549 Tidskriftsartikel (refereegranskat)abstract BACKGROUND: Infections in early life are associated with asthma and allergies in one-generation settings; however, the link between parental infection and offspring phenotype is rarely investigated. We aim to study the association of parental TB before conception of the offspring with offspring asthma and rhinitis.METHODS: We included 2,965 offspring born in 1985- 2004 and registered in the Norwegian prescription database to 1,790 parents born after 1960 with a history of TB, and included in the Norwegian TB registry. Offspring asthma (n = 582) and rhinitis (n = 929) were defined based on diagnosis, type of medication and prescribed medication >1 year. Associations of parental TB ,8 years, >8 years but before offsprings birth year and after birth (reference category) with offspring asthma and rhinitis were analysed using logistic regression.RESULTS: Asthma risk was higher in persons with parental TB in childhood (OR 1.73, 95% CI 1.20- 2.50) or later preconception (OR 1.38, 95% CI 1.00- 1.91) than in persons with parental TB after offsprings birth; this was significant only in the maternal line (childhood: OR 1.95, 95% CI 1.13-3.37; later precon-ception: OR 1.74, 95% CI 1.08-2.80). Associations with rhinitis were not identified.CONCLUSIONS: Parental childhood TB was associated with higher asthma risk in future offspring. We speculate that TB impacts maternal immunity , dysregulates the offsprings type 2 immunity , that TB-induced epigenetic reprograming of immune defences are trans-ferred to the offspring.

Skapa referenser, mejla, bekava och länka

Länka till träfflistan

Resultat 1-3 av 3

Avgränsa träffmängd

Typ av publikation: tidskriftsartikel (1)

Typ av innehåll: refereegranskat (1)

Författare/redaktör: Chen, L (2); Chen, S. (2); King, M. (2); Lopes, L. (2); Losada, M. (2); Moss, J. (2); visa fler...; Negri, G. (2); Qureshi, A. (2); Robson, A. (2); Romano, M. (2); Zhang, H. (2); Morton, A. (2); Davies, E. (2); Gupta, A. (2); Kelly, M. (2); Bertoli, G (2); Coe, P. (2); Price, S (2); Martin, J. (2); Aytac, E (2); Campain, N (2); Davies, RJ (2); Domingo, S (2); Golda, T (2); Hompes, R (2); Lago, (2); Lakkis, Z (2); Maciel, J (2); Rottoli, M (2); Shaikh, (2); Tsarkov, P (2); Wilson, M (2); Baker, A. (2); Silva, M. (2); Jones, M. (2); Kumar, A. (2); Moore, R. (2); Osman, N. (2); Russ, J. (2); Shaw, S. (2); Hogan, J. (2); Williams, G. (2); Giraudo, G. (2); Kisiel, A. (2); Roy, C. (2); Sharma, N. (2); Singh, R. (2); Scott, R. (2); Song, J. (2); Grassi, T. (2); visa färre...

Lärosäte: Karolinska Institutet (2); Linköpings universitet (1)

Språk: Engelska (3)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - Nationella bibliotekssystem
LIBRIS.kb.se

pil uppåt

Stäng

Kopiera och spara länken för att återkomma till aktuell vy