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Träfflista för sökning "WFRF:(Hosseinpanah Farhad) "

Sökning: WFRF:(Hosseinpanah Farhad)

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  • Rambod, Mehdi, et al. (författare)
  • Fine-tuning of prediction of isolated impaired glucosetolerance: A quantitative clinical prediction model
  • 2008
  • Ingår i: Diabetes Research and Clinical Practice. - 0168-8227 .- 1872-8227.
  • Tidskriftsartikel (refereegranskat)abstract
    • In this cross-sectional study, we evaluated results of oral glucose tolerance test (OGTT) from4742 women and 3470 men, participated in the Tehran Lipid and Glucose Study, aged 20years and without diabetes, to determine the diagnostic value of subjects’ clinical traits withisolated impaired glucose tolerance (isolated-IGT) defined as fasting plasma glucose (FPG)<5.6 mmol/L and 2-h plasma glucose between 7.8 and 11.1 mmol/L. The overall prevalenceof IGT was 13.6% (n = 1120); of these subjects, 59.6% (n = 668) had isolated-IGT. The adjustedodds ratios for having isolated-IGT among 7012 subjects with FPG <5.6 mmol/L weresignificant for age 40 years (2.5), hypertension (1.9), abnormal waist circumference (1.9),obesity (1.5), and family history of diabetes (1.3). Adding the lipid profiles to the clinicalmodel increased the area under the ROC curve only slightly (73.2% vs. 72.1%, respectively;P = 0.002). In summary, this study showed that in adults with FPG <5.6 mmol/L, older age,family history of diabetes, abnormal waist circumference and obesity, and hypertensionwere significantly associated with a higher likelihood of isolated-IGT; OGTT could hence berecommended in subjects who have most of these characteristics to find Isolated-IGT,especially if the findings are supported by appropriately designed clinical trials.
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  • Styrkarsdottir, Unnur, et al. (författare)
  • Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis
  • 2017
  • Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 49:5, s. 801-805
  • Tidskriftsartikel (refereegranskat)abstract
    • We performed a genome-wide association study of total hip replacements, based on variants identified through whole-genome sequencing, which included 4,657 Icelandic patients and 207,514 population controls. We discovered two rare signals that strongly associate with osteoarthritis total hip replacement: a missense variant, c.1141G>C (p.Asp369His), in the COMP gene (allelic frequency = 0.026%, P = 4.0 × 10-12, odds ratio (OR) = 16.7) and a frameshift mutation, rs532464664 (p.Val330Glyfs∗106), in the CHADL gene that associates through a recessive mode of inheritance (homozygote frequency = 0.15%, P = 4.5 × 10-18, OR = 7.71). On average, c.1141G>C heterozygotes and individuals homozygous for rs532464664 had their hip replacement operation 13.5 years and 4.9 years earlier than others (P = 0.0020 and P = 0.0026), respectively. We show that the full-length CHADL transcript is expressed in cartilage. Furthermore, the premature stop codon introduced by the CHADL frameshift mutation results in nonsense-mediated decay of the mutant transcripts.
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