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- Campbell, PJ, et al.
(författare)
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Pan-cancer analysis of whole genomes
- 2020
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 578:7793, s. 82-
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Tidskriftsartikel (refereegranskat)abstract
- Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1–3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4–5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10–18.
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| 3. |
- Hou, Yandong, et al.
(författare)
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Numerical study on surface corrosion deposition of fuel elements and its influence on flow heat transfer
- 2024
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Ingår i: Annals of Nuclear Energy. - : Elsevier BV. - 0306-4549 .- 1873-2100. ; 201
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Tidskriftsartikel (refereegranskat)abstract
- Corrosion of pressurized water reactors (PWR) in nuclear power plants can lead to serious safety hazards. This study aims to analyze the deposition of corrosion products using FLUENT software. Deposition models and thermal resistance models were developed, and the effects of deposits on the reactor's thermal–hydraulic characteristics were evaluated. Additionally, the impact of various parameters on deposition and thermal–hydraulic characteristics was examined. Results show that deposits accumulate extensively in the inlet section of the fuel cladding, while appearing as spot deposits in the outlet section. For deposit thicknesses below 30 μm, the surface temperature of the cladding gradually increases. However, when the thickness exceeds 30 μm, the surface temperature rapidly rises. Furthermore, the study reveals that the deposition amount decreases with increasing inlet flow velocity, exhibits an upward trend with higher inlet temperature, and increases with a higher wall heat flux density. This research provides important insights for understanding core deposition and thermal–hydraulic characteristics in nuclear reactor systems. It offers valuable guidance for enhancing safety and operational efficiency in nuclear power plants.
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