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| 2. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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| 3. |
- Ali, Asad, et al.
(författare)
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Emerging strategies and developments in oxygen reduction reaction using high-performance platinum-based electrocatalysts
- 2024
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Ingår i: Nano Reseach. - : Tsinghua University Press. - 1998-0124 .- 1998-0000. ; 17:5, s. 3516-3532
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Forskningsöversikt (refereegranskat)abstract
- The global practical implementation of proton exchange membrane fuel cells (PEMFCs) heavily relies on the advancement of highly effective platinum (Pt)-based electrocatalysts for the oxygen reduction reaction (ORR). To achieve high ORR performance, electrocatalysts with highly accessible reactive surfaces are needed to promote the uncovering of active positions for easy mass transportation. In this critical review, we introduce different approaches for the emerging development of effective ORR electrocatalysts, which offer high activity and durability. The strategies, including morphological engineering, geometric configuration modification via supporting materials, alloys regulation, core-shell, and confinement engineering of single atom electrocatalysts (SAEs), are discussed in line with the goals and requirements of ORR performance enhancement. We review the ongoing development of Pt electrocatalysts based on the syntheses, nanoarchitecture, electrochemical performances, and stability. We eventually explore the obstacles and research directions on further developing more effective electrocatalysts.
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| 4. |
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| 5. |
- Chen, Zhuo, et al.
(författare)
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Reliability-Oriented Multi-Objective Optimization of Electrical Machines Considering Insulation Thermal Lifetime Prediction
- 2024
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Ingår i: IEEE Transactions on Transportation Electrification. - : Institute of Electrical and Electronics Engineers (IEEE). - 2332-7782. ; 10:1, s. 2264-2276
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Tidskriftsartikel (refereegranskat)abstract
- With the trend toward transportation electrification, the power density of electrical machines faces ever-increasing requirement owing to the stringent limit of weight, especially for aerospace applications. Conventionally, the reliability of electrical machines in such safety-critical application is guaranteed by considerable safety margins, i.e., the over-engineering approach, which prevents electrical machines from reaching higher power densities and leads to a design conflict. This paper proposes a reliability-oriented design approach for low-voltage electrical machines by integrating model-based lifetime prediction into a multi-objective optimization process. Accelerated thermal degradation tests are carried out on mainwall insulation and turn insulation, then the thermal degradation model is built to predict the lifetimes, accordingly. Thermal lifetime models are developed at several lifetime percentiles for both continuous duty and variable duty applications. Finally, a feasible reliability-oriented multi-objective optimization platform is established, based on which a study-case electrical machine for aerospace application is designed and optimized. The prototype is manufactured to verify the optimized performances.
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| 6. |
- Fei, Keke, et al.
(författare)
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LcrQ coordinates with the YopD-LcrH complex to repress lcrF expression and control type III secretion by Yersinia pseudotuberculosis
- 2021
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Ingår i: mBio. - : American Society for Microbiology (ASM). - 2161-2129 .- 2150-7511. ; 12:3
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Tidskriftsartikel (refereegranskat)abstract
- Human-pathogenic Yersinia species employ a plasmid-encoded type III secretion system (T3SS) to negate immune cell function during infection. A critical element in this process is the coordinated regulation of T3SS gene expression, which involves both transcriptional and posttranscriptional mechanisms. LcrQ is one of the earliest identified negative regulators of Yersinia T3SS, but its regulatory mechanism is still unclear. In a previous study, we showed that LcrQ antagonizes the activation role played by the master transcriptional regulator LcrF. In this study, we confirm that LcrQ directly interacts with LcrH, the chaperone of YopD, to facilitate the negative regulatory role of the YopD-LcrH complex in repressing lcrF expression at the posttranscriptional level. Negative regulation is strictly dependent on the YopD-LcrH complex, more so than on LcrQ. The YopD-LcrH complex helps to retain cytoplasmic levels of LcrQ to facilitate the negative regulatory effect. Interestingly, RNase E and its associated protein RhlB participate in this negative regulatory loop through a direct interaction with LcrH and LcrQ. Hence, we present a negative regulatory loop that physically connects LcrQ to the posttranscriptional regulation of LcrF, and this mechanism incorporates RNase E involved in mRNA decay.
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| 7. |
- Guo, Yingying, et al.
(författare)
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Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro, Imaging and Physiologically Based Pharmacokinetic Modeling Approaches
- 2018
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Ingår i: Clinical Pharmacology and Therapeutics. - : John Wiley & Sons. - 0009-9236 .- 1532-6535. ; 104:5, s. 865-889
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Forskningsöversikt (refereegranskat)abstract
- This white paper examines recent progress, applications, and challenges in predicting unbound and total tissue and intra/subcellular drug concentrations using in vitro and preclinical models, imaging techniques, and physiologically based pharmacokinetic (PBPK) modeling. Published examples, regulatory submissions, and case studies illustrate the application of different types of data in drug development to support modeling and decision making for compounds with transporter-mediated disposition, and likely disconnects between tissue and systemic drug exposure. The goals of this article are to illustrate current best practices and outline practical strategies for selecting appropriate in vitro and in vivo experimental methods to estimate or predict tissue and plasma concentrations, and to use these data in the application of PBPK modeling for human pharmacokinetic (PK), efficacy, and safety assessment in drug development.
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| 8. |
- Hao, Wende, et al.
(författare)
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Vitronectin : a promising breast cancer serum biomarker for early diagnosis of breast cancer in patients
- 2016
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Ingår i: Tumor Biology. - : Springer. - 1010-4283 .- 1423-0380. ; 37:7, s. 8909-8916
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Tidskriftsartikel (refereegranskat)abstract
- Breast cancer is the most common cancer in women worldwide, identification of new biomarkers for early diagnosis and detection will improve the clinical outcome of breast cancer patients. In the present study, we determined serum levels of vitronectin (VN) in 93 breast cancer patients, 30 benign breast lesions, 9 precancerous lesions, and 30 healthy individuals by enzyme-linked immunosorbent assays. Serum VN level was significantly higher in patients with stage 0-I primary breast cancer than in healthy individuals, patients with benign breast lesion or precancerous lesions, as well as those with breast cancer of higher stages. Serum VN level was significantly and negatively correlated with tumor size, lymph node status, and clinical stage (p < 0.05 in all cases). In addition, VN displayed higher area under curve (AUC) value (0.73, 95 % confidence interval (CI) [0.62-0.84]) than carcinoembryonic antigen (CEA) (0.64, 95 % CI [0.52-0.77]) and cancer antigen 15-3 (CA 15-3) (0.69, 95 % CI [0.58-0.81]) when used to distinguish stage 0-I cancer and normal control. Importantly, the combined use of three biomarkers yielded an improvement in receiver operating characteristic curve with an AUC of 0.83, 95 % CI [0.74-0.92]. Taken together, our current study showed for the first time that serum VN is a promising biomarker for early diagnosis of breast cancer when combined with CEA and CA15-3.
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| 9. |
- Huang, Jing, et al.
(författare)
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Development of a human head and neck muscle activation control model based on BPNN
- 2018
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Ingår i: Journal of Intelligent and Fuzzy Systems. - 1875-8967 .- 1064-1246. ; 34:2, s. 1161-1167
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Tidskriftsartikel (refereegranskat)abstract
- With the development of vehicle active safety technology and its combination with passive safety technologies, there is a need for an updated tool to assess the performance of vehicle safety systems in both the in-crash and pre-crash phases. Consequently, developing human body models with active muscles is critical to achieve improved bio-fidelity simulation results to evaluate the effects of safety systems. In the present study, an innovative human active muscle control model based on a back-propagation neural network (BPNN) controller was developed, and the active muscle response was modelled using a feedback control strategy with the BPNN algorithm implemented in a human head and neck Sim Mechanics model. The BPNN controller was used to dynamically control the muscle activation level, the most complicated and essential factor in active muscle force calculation based on the Hill equation. Then, the active muscle control model was evaluated by simulating the human response in volunteer sled tests. The results validated the proposed active muscle control method as successful and easily realized. Achieving muscle active control would further improve the bio-fidelity of the human body model.
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| 10. |
- Huang, Xiaoyan, et al.
(författare)
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A Robust Deadbeat Predictive Current Control Method for IPMSM
- 2024
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Ingår i: IEEE Transactions on Transportation Electrification. - : Institute of Electrical and Electronics Engineers (IEEE). - 2332-7782. ; , s. 1-1
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Tidskriftsartikel (refereegranskat)abstract
- Deadbeat predictive current control (DPCC) demonstrates excellent dynamic performance. However, in practical applications, its effectiveness is degraded by parameter mismatches and inverter nonlinearities. Among the various improvement methods addressed for these issues, incremental model-based DPCC (I-DPCC) achieves zero static current error with a low computational burden but suffers from instability under parameter variation, especially when applied to interior permanent magnet synchronous motors (IPMSMs). In this paper, a robust I-DPCC (RI-DPCC) combining feedforward control is proposed for IPMSM, with an adjustable stable operation range that can be extended to twice the actual inductance or even larger. To further improve the robustness of dynamic performance, an inductance correction method is introduced to track the variation of inductance during dynamic processes. Thus, the current commands can be well tracked even when significant inductance variation occurs. With sufficient voltage margin, the dynamic processes under mismatched inductance can be shortened to four control periods. Finally, experimental results validate the effectiveness of the proposed method.
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