| 1. |
- Andersson, Jens K, et al.
(författare)
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Performance analysis and overload control of an open service access (OSA) architecture
- 2003
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Ingår i: Performance and control of next-generation communication networks : [ITCom's Conference on Performance and Control of Next-Generation Communication Networks] ; 9 - 10 September 2003, Orlando, Florida, USA (SPIE proceedings series). - : SPIE. - 0819451274 ; 5244, s. 176-186
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Konferensbidrag (refereegranskat)abstract
- The trend of the service architectures developed in telecommunications today is that they should be open in the sense thatthey can communicate over the borders of different networks. Instead of each network having their own service architecture with their own applications, all networks should be able to use the same applications. 3GPP, the organization developing specifications for the 3G networks has specified the standard Open Service Access (OSA), as a part of the 3G specification. OSA offers different Application Protocol Interfaces that enable an application that resides outside a network to use the capabilities of the network. This paper analyses the performance of an OSA gateway. It is examined how the overload control can be dealt with in a way to best satisfy the operators and the 3'rd parties. There are some guiding principles in the specifications, but a lot of decisions have to be made by the implementors of application servers and OSA gateways. Proposals of different requirements for an OSA architecture exist such as, minimum amount of accepted calls per second and time constraint for the maximal total delay for an application. Maximal and fair throughput have to be prioritized from the 3'rd parties view, but profit is the main interest from the operators point of view. Therefore this paperexamines a priority based proposal of an overload control mechanism taking these aspects and requirements into account.
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| 2. |
- Andersson, Mikael, et al.
(författare)
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Modelling and Design of Admission Control Mechanisms for Web Servers using Non-linear Control Theory
- 2003
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Ingår i: Performance and control of next-generation communication networks : [ITCom's Conference on Performance and Control of Next-Generation Communication Networks] ; 9 - 10 September 2003, Orlando, Florida, USA (SPIE proceedings series ; vol. 5244). - : SPIE. - 1996-756X .- 0277-786X. - 0819451274 ; 5244:1, s. 53-64
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Konferensbidrag (refereegranskat)abstract
- Web sites are exposed to high rates of incoming requests. Since web sites are sensitive to overload, admission control mechanisms are often implemented. The purpose of such a mechanism is to prevent requests from entering the web server during high loads. This paper presents how admission control mechanisms can be designed and implemented with a combination of queueing theory and control theory. Since web servers behave non-linear and stochastic, queueing theory can be used for web server modelling. However, there are no mathematical tools in queueing theory to use when designing admission control mechanisms. Instead, control theory contains the needed mathematical tools. By analysing queueing systems with control theoretic methods, good admission control mechanisms can be designed for web server systems. In this paper we model an Apache web server as a GI/G/1-system. Then, we use control theory to design a PI-controller, commonly used in automatic control, for the web server. In the paper we describe the design of the controller and also how itcan be implemented in a real system. The controller has been implemented and tested together with the Apache web server. The server was placed in a laboratory network together with a traffic generator which was used to represent client requests. Measurements in the laboratory setup show how robust the implemented controller is, and how it correspond to the results from the theoretical analysis.
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| 3. |
- van Rheenen, Wouter, et al.
(författare)
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Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis
- 2016
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 48:9, s. 1043-1048
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Tidskriftsartikel (refereegranskat)abstract
- To elucidate the genetic architecture of amyotrophic lateral sclerosis (ALS) and find associated loci, we assembled a custom imputation reference panel from whole-genome-sequenced patients with ALS and matched controls (n = 1,861). Through imputation and mixed-model association analysis in 12,577 cases and 23,475 controls, combined with 2,579 cases and 2,767 controls in an independent replication cohort, we fine-mapped a new risk locus on chromosome 21 and identified C21orf2 as a gene associated with ALS risk. In addition, we identified MOBP and SCFD1 as new associated risk loci. We established evidence of ALS being a complex genetic trait with a polygenic architecture. Furthermore, we estimated the SNP-based heritability at 8.5%, with a distinct and important role for low-frequency variants (frequency 1-10%). This study motivates the interrogation of larger samples with full genome coverage to identify rare causal variants that underpin ALS risk.
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