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- Assimes, Themistocles L., et al.
(författare)
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Lack of Association Between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies
- 2010
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Ingår i: Journal of the American College of Cardiology. - : Elsevier BV. - 0735-1097. ; 56:19, s. 1552-1563
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Tidskriftsartikel (refereegranskat)abstract
- Objectives We sought to replicate the association between the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism (rs20455), and clinical coronary artery disease (CAD). Background Recent prospective studies suggest that carriers of the 719Arg allele in KIF6 are at increased risk of clinical CAD compared with noncarriers. Methods The KIF6 Trp719Arg polymorphism (rs20455) was genotyped in 19 case-control studies of nonfatal CAD either as part of a genome-wide association study or in a formal attempt to replicate the initial positive reports. Results A total of 17,000 cases and 39,369 controls of European descent as well as a modest number of South Asians, African Americans, Hispanics, East Asians, and admixed cases and controls were successfully genotyped. None of the 19 studies demonstrated an increased risk of CAD in carriers of the 719Arg allele compared with noncarriers. Regression analyses and fixed-effects meta-analyses ruled out with high degree of confidence an increase of >= 2% in the risk of CAD among European 719Arg carriers. We also observed no increase in the risk of CAD among 719Arg carriers in the subset of Europeans with early-onset disease (younger than 50 years of age for men and younger than 60 years of age for women) compared with similarly aged controls as well as all non-European subgroups. Conclusions The KIF6 Trp719Arg polymorphism was not associated with the risk of clinical CAD in this large replication study. (J Am Coll Cardiol 2010;56:1552-63) (C) 2010 by the American College of Cardiology Foundation
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| 2. |
- Fristedt, Mårten, et al.
(författare)
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Supply chain management in practice : a case study of McDonald’s Sweden
- 2012
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Although much discussed in theory, supply chain management (SCM) is often problematic to carry out in practice. One exception is McDonald’s Sweden, which since its establishment has worked with suppliers and restaurants (franchisees) in a way that reminds of what SCM literature recommends. The purpose of this report is to describe and analyse the supply chain of McDonald’s Sweden from suppliers to franchisees.Based on interviews with McDonald’s Sweden, suppliers and franchisees, McDonald’s supply chain is described and analysed according to SCM literature. Cooper and Ellram’s (1993) framework of SCM characteristics is used complemented with several other writers.The study describes a supply chain where its members to a large extent collaborate as described in SCM literature. The report identifies and describes how significant SCM characteristics, such as information sharing, joint planning, and the sharing of risks and rewards are managed in the case. Finally, the report identifies market saturation and the search for economies of scale outside the primary supply chain as a challenge for future SCM practices. The case constitutes an interesting showcase where the ways in which the studied features are managed can inspire others businesses in succeeding in SCM.
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| 4. |
- Jazairy, Amer, 1989-
(författare)
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Engaging in green logistics: An eye on shippers, logistics service providers, and their interactions
- 2020
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The logistics and transport industry places a heavy load on the environment, causing various harms such as air pollution, global warming and resource depletion. The logistics and supply chain management literature assigns the largest share of responsibility for alleviating such harms to two supply chain actors: shippers (i.e., logistics buyers) and logistics service providers (LSPs), which motivated focusing on them in this thesis. Specifically, the purpose of this thesis is to investigate the engagements of shippers and LSPs in different green logistics practices (GLPs) throughout the logistics purchasing process, and to propose improvements for such engagements by their interactions.Three research questions drive this investigation. The first question handles comparing the drivers (i.e., institutional pressures) for shippers to purchase GLPs and for LSPs to provide them—to reveal how this ‘one-tier network’ is driven as a whole. The second question aims to describe how shippers and LSPs engage in the different GLPs throughout the logistics purchasing process (across its four phases: request for proposal, negotiations, contracting and execution) and why such engagement takes place as it does. The third question aims to propose improvements for shippers’ and LSPs’ engagements in the different GLPs throughout the process—by enacting different degrees of interactions (cooperation vs. collaboration). A methodological triangulation approach is used to answer these questions, based on five papers that are extracted from three studies: a single case (shipper-LSP dyad), a multiple case (3 shippers, 5 LSPs) and a survey (169 shippers, 162 LSPs).The findings reveal a lack of direct regulatory, market and competitive pressures on shippers to purchase GLPs. These are compared to existing (yet insufficient) regulatory pressure, effective market pressure and emergent competitive pressure on LSPs to provide GLPs. The findings also reveal gaps between the actors’ purchasing-providing engagements in GLPs across the purchasing process, which followed three patterns: steady & wide, steady & narrow and emergent. Distinct GLPs are associated with each pattern, and detailed explanations are presented for these associations based on the characteristics of each GLP . Further, the findings propose paths to improve the actors’ engagements in GLPs across the process, based on the gap pattern for each GLP and the degrees of shipper-LSP interactions required for it (cooperation vs. collaboration).This thesis contributes to the body of knowledge through systematically incorporating a trilateral actor-, phase- and GLP-specific distinction into the green logistics purchasing discussion. Also, it transcends the descriptive (and general) level of analysis of shippers’ and LSPs’ green engagements during the logistics purchasing process, by: (i) explaining why such engagements occur as they do and (ii) providing recommendations that could actually improve these engagements. Insights are offered to managers at shipper/LSP firms to assist them in modifying their purchasing/marketing strategies throughout the purchasing process with respect to specifically targeted GLPs. Insights are also offered to policymakers to set suitable regulations on both actors to support ‘greening’ logistics networks.
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