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- Jackson, Illiam, 1986-
(författare)
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Morphometric analysis of Cambrian fossils and its evolutionary significance
- 2017
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The Extended Evolutionary Synthesis (EES) is currently emerging as a theoretical alternative to the Modern Synthesis (MS) in which to frame evolutionary observations and interpretations. These alternative frameworks differ fundamentally in their understanding of the relative roles of the genotype, phenotype, development and environment in evolutionary processes and patterns. While the MS represents a gene-centred view of evolution, the EES instead emphasizes the interactions between organism, development and environment. This novel theoretical framework has generated a number of evolutionary predictions that are mutually incompatible with the equivalent of the MS. While research and empirical testing has begun on a number of these in a neontological context, the field of palaeontology has yet to contribute meaningfully to this endeavour. One of the reasons for this is a lack of methodological approaches capable of investigating relevant evolutionary patterns in the fossil record. In this thesis morphometric methods capable of providing relevant data are developed and employed in the analysis of Cambrian fossils. Results of these analyses provide empirical support for the process of evolution through phenotypic plasticity and genetic assimilation hypothesized by the EES. Furthermore, theoretical revision to the species concept in a palaeontological context is suggested. Finally, predictions of the EES specific to the fossil record are made explicit and promising directions of future research are outlined.
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| 2. |
- Marcinkiewicz, Katarzyna, et al.
(författare)
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The androgen receptor and stem cell pathways in prostate and bladder cancers (review).
- 2012
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Ingår i: International Journal of Oncology. - : Spandidos Publications. - 1019-6439 .- 1791-2423. ; 40:1, s. 5-12
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Tidskriftsartikel (refereegranskat)abstract
- Bladder cancer is three times more common in men than in women. However, the physiological basis of the male predominance of bladder cancer remains poorly understood. A higher than expected association of prostate and bladder cancers has also been reported which may indicate a common mechanism of carcinogenesis. Consistent with this, androgens and the androgen receptor (AR) play essential roles in prostate carcinogenesis and are believed to play a role in bladder carcinogenesis. There is also evidence implicating cancer stem cells in prostate and bladder cancers. Indeed putative prostate and bladder cancer stem cells share some common molecular features. We highlight key proteins (CD49f, CD133, PTEN, CD44) which are implicated in both prostate and bladder cancers and are enriched in putative prostate and bladder cancer stem cells. We examine published chromatin immuno-precipitation studies analyzing the genome-wide distribution of the AR to identify AR association with, and by inference potential AR-regulation of, these loci. We discuss recent evidence indicating a role for the AR in the splicing of the key urological stem cell protein CD44. We propose a model whereby aberrant AR regulation of these putative stem cell proteins contributes to malignant transformation of prostate and bladder cells. For these reasons we propose that the relationship between androgens and cancer stem cell associated proteins warrants further investigation.
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| 3. |
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| 4. |
- Watts, Nick, et al.
(författare)
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The 2020 report of The Lancet Countdown on health and climate change : responding to converging crises
- 2021
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Ingår i: The Lancet. - : Elsevier. - 0140-6736 .- 1474-547X. ; 397:10269, s. 129-170
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Forskningsöversikt (refereegranskat)abstract
- The Lancet Countdown is an international collaboration established to provide an independent, global monitoring system dedicated to tracking the emerging health profile of the changing climate.The 2020 report presents 43 indicators across five sections: climate change impacts, exposures, and vulnerabilities; adaptation, planning, and resilience for health; mitigation actions and health co-benefits; economics and finance; and public and political engagement. This report represents the findings and consensus of the 35 leading academic institutions and UN agencies that make up The Lancet Countdown, and draws on the expertise of climate scientists, geographers, engineers, experts in energy, food, and transport, economists, social, and political scientists, data scientists, public health professionals, and doctors.
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