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- Andersson, Mats, et al.
(författare)
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Road Friction Estimation
- 2007
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This project is part of the Swedish IVSS program. The aim of IVSS is to stimulate research and development for the road safety of the future. Road conditions with low friction have been identified as a frequent cause of traffic accidents. Therefore, technology to automaticallydetect changes in road conditions and alert the driver or take proper actions with active driver support systems would be a key contribution to increased road safety.The aim of this project was to investigate the possibilities to estimate the tire to road friction.Three different approaches have been developed and evaluated, from concept to early prototypes in test vehicles. In the first method, the estimation of the coefficient of friction is based on the forces and torques that are produced at the front tires at cornering maneuvers.The second method is based on a physical model of the tire behavior and estimates road friction from information on the forces that are produced at straight driving. The third method is based on an optical sensor that classifies the road surface ahead of the vehicle.The three methods have been successfully evaluated in proving ground and public road tests in summer and winter conditions with different tires, and have been compared with reference measurements. The conclusion is that all three methods can be used for tire to road frictionestimation and are recommended for further development and industrialization.
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| 2. |
- Ersmark, Karolina, et al.
(författare)
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C2-symmetric inhibitors of Plasmodium falciparum plasmepsin II : synthesis and theoretical predictions
- 2003
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Ingår i: Bioorganic & Medicinal Chemistry. - 0968-0896 .- 1464-3391. ; 11:17, s. 3723-3733
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Tidskriftsartikel (refereegranskat)abstract
- A series of C(2)-symmetric compounds with a mannitol-based scaffold has been investigated, both theoretically and experimentally, as Plm II inhibitors. Four different stereoisomers with either benzyloxy or allyloxy P1/P1' side chains were studied. Computational ranking of the binding affinities of the eight compounds was carried out using the linear interaction energy (LIE) method relying on a complex previously determined by crystallography. Within both series of isomers the theoretical binding energies were in agreement with the enzymatic measurements, illustrating the power of the LIE method for the prediction of ligand affinities prior to synthesis. The structural models of the enzyme-inhibitor complexes obtained from the MD simulations provided a basis for interpretation of further structure-activity relationships. Hence, the affinity of a structurally similar ligand, but with a different P2/P2' substituent was examined using the same procedure. The predicted improvement in binding constant agreed well with experimental results.
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| 8. |
- Hultén, Johan, et al.
(författare)
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Cyclic HIV-1 protease inhibitors derived from mannitol : synthesis, inhibitory potencies, and computational predictions of binding affinities
- 1997
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Ingår i: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 40:6, s. 885-897
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Tidskriftsartikel (refereegranskat)abstract
- Ten C-2-symmetric cyclic urea and sulfamide derivatives have been synthesized from L-mannonic gamma-lactone and D-mannitol. The results of experimental measurement of their inhibitory potencies against HIV-1 protease were compared to calculated free energies of binding derived from molecular dynamics (MD) simulations. The compounds were selected, firstly, to enable elucidation of the role of stereochemistry for binding affinity (1a-d) and, secondly, to allow evaluation of the effects of variation in the link to the P1 and P1' phenyl groups on affinity (la and 2-5). Thirdly, compounds with hydrogen bond-accepting or -donating groups attached to the phenyl groups in the P2 and P2' side chains (6 and 7) were selected. Binding free energies were estimated by a linear response method, whose predictive power for estimating binding affinities from MD simulations was demonstrated.
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| 9. |
- Hultén, Johan, et al.
(författare)
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Potential för ökad återanvändning – fallstudie återvinningscentraler Återanvändbara produkter och farliga ämnen i avfall
- 2018
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Plockanalys innebär en metodisk eftersortering av avfall. I projektet gjorde vi uppdelning i olika produktgrupper och utefter potential för återanvändning. Avfallet samlades in från två återvinningscentraler, höst och vår, från fyra olika insamlingsfraktioner. Mätning med XRF-skanner av drygt 300 produkter utfördes vid plockanalyserna, varav 30 produkter även analyserades på laboratorium. Farliga ämnen hittades i många produkter, men i små mängder.
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| 10. |
- Palmberg, Lars Johan, 1713-1804
(författare)
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Dissertatio theologica, de mutuo influxu theologiæ dogmaticæ et moralis, cujus partem priorem, suffragante max. vener. theologorum ordine, in illustri academia Upsal. ad publicum examen deferunt, m. Laur. Jo. Palmberg ... & respondens, Petrus Hultén, sudermannus, stip. reg. In audit. Gust. majori, die XXXI maji, MDCCXCIV, P.1
- 1794
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)
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