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- Eriksson, Staffan, et al.
(författare)
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Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead
- 2015
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Ingår i: Carcinogenesis. - : Oxford University Press (OUP). - 0143-3334 .- 1460-2180. ; 36, s. S254-S296
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Forskningsöversikt (refereegranskat)abstract
- Low-dose exposures to common environmental chemicals that are deemed safe individually may be combining to instigate carcinogenesis, thereby contributing to the incidence of cancer. This risk may be overlooked by current regulatory practices and needs to be vigorously investigated.Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that low-dose exposures to mixtures of chemicals in the environment may be combining to contribute to environmental carcinogenesis, we reviewed 11 hallmark phenotypes of cancer, multiple priority target sites for disruption in each area and prototypical chemical disruptors for all targets, this included dose-response characterizations, evidence of low-dose effects and cross-hallmark effects for all targets and chemicals. In total, 85 examples of chemicals were reviewed for actions on key pathways/mechanisms related to carcinogenesis. Only 15% (13/85) were found to have evidence of a dose-response threshold, whereas 59% (50/85) exerted low-dose effects. No dose-response information was found for the remaining 26% (22/85). Our analysis suggests that the cumulative effects of individual (non-carcinogenic) chemicals acting on different pathways, and a variety of related systems, organs, tissues and cells could plausibly conspire to produce carcinogenic synergies. Additional basic research on carcinogenesis and research focused on low-dose effects of chemical mixtures needs to be rigorously pursued before the merits of this hypothesis can be further advanced. However, the structure of the World Health Organization International Programme on Chemical Safety 'Mode of Action' framework should be revisited as it has inherent weaknesses that are not fully aligned with our current understanding of cancer biology.
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- Kullenberg, Christopher, 1980, et al.
(författare)
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What are analog bulletin boards used for today? Analysing media uses, intermediality and technology affordances in Swedish bulletin board messages using a citizen science approach
- 2018
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 13:8
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Tidskriftsartikel (refereegranskat)abstract
- Analog bulletin boards are omnipresent in Swedish urban areas, yet little systematic knowledge about this communication medium exists. In the shadow of the rapid emergence of digital media the analog bulletin board has received less attention than its digital successors, many of them having incorporated similar functionality with novel technical solutions. In this study we used a citizen science method to collect 1167 messages from bulletin boards around Sweden aided by school children and teachers, with the purpose of shedding new light on what is communicated on the boards, by whom, using what types of technologies and in what way the messages refer to other media. Results show that the most common messages are invitations to events, such as concerts, lectures and sports events, followed by buy-and-sell ads for goods and services. The most frequent sender is an association, for example NGOs, sports associations or religious communities. Almost half of the sampled messages were professionally printed, about forty per cent were made by home printers. Only six per cent of the messages were handwritten, almost exclusively by private persons as senders. Moreover, we show how the analog bulletin board has adapted to recent changes in media technology—a media landscape which is saturated with electronic- and mobile media. Further, the bulletin board still holds a firm place in a media ecology where local communication is in demand, and exists in parallel with electronic media. Close to forty percent of the messages contained hyperlinks to web pages and we found (and removed for anonymization purposes) more than six hundred phone numbers from the dataset.
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- Moberg, Christina, et al.
(författare)
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De unga gör helt rätt när de stämmer staten
- 2022
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Ingår i: Aftonbladet. - 1103-9000.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
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