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Sökning: WFRF:(Hunt Jasmine N.)

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1.
  • Bjelic, Sinisa, et al. (författare)
  • Computational design of enone-binding proteins with catalytic activity for the Morita-Baylis-Hillman reaction
  • 2013
  • Ingår i: ACS Chemical Biology. - : American Chemical Society (ACS). - 1554-8929 .- 1554-8937. ; 8:4, s. 749-757
  • Tidskriftsartikel (refereegranskat)abstract
    • The Morita-Baylis-Hillman reaction forms a carbon-carbon bond between the α-carbon of a conjugated carbonyl compound and a carbon electrophile. The reaction mechanism involves Michael addition of a nucleophile catalyst at the carbonyl β-carbon, followed by bond formation with the electrophile and catalyst disassociation to release the product. We used Rosetta to design 48 proteins containing active sites predicted to carry out this mechanism, of which two show catalytic activity by mass spectrometry (MS). Substrate labeling measured by MS and site-directed mutagenesis experiments show that the designed active-site residues are responsible for activity, although rate acceleration over background is modest. To characterize the designed proteins, we developed a fluorescence-based screen for intermediate formation in cell lysates, carried out microsecond molecular dynamics simulations, and solved X-ray crystal structures. These data indicate a partially formed active site and suggest several clear avenues for designing more active catalysts.
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2.
  • Kang, Taegon, et al. (författare)
  • Facile access to internally functionalized dendrimers through efficient and orthogonal click reactions
  • 2010
  • Ingår i: Chemical Communications. - : Royal Society of Chemistry (RSC). - 1359-7345 .- 1364-548X. ; 46:9, s. 1556-1558
  • Tidskriftsartikel (refereegranskat)abstract
    • A simple synthetic strategy has been developed for accessing internally functionalized dendrimers. The key feature of this approach is the use of two orthogonal and efficient reactions` epoxy-amine' and 'thiol-ene' coupling-for rapid growth of the dendritic scaffold. This sequence of reactions allows for the introduction of reactive hydroxyl groups at each dendritic layer.
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3.
  • Wu, Peng, et al. (författare)
  • Multivalent, bifunctional dendrimers prepared by click chemistry
  • 2005
  • Ingår i: Chemical Communications. - : Royal Society of Chemistry (RSC). - 1359-7345 .- 1364-548X. ; :46, s. 5775-5777
  • Tidskriftsartikel (refereegranskat)abstract
    • Unsymmetrical dendrimers, containing both mannose binding units and coumarin fluorescent units, have been prepared using click chemistry and shown to be highly efficient, dual-purpose recognition/detection agents for the inhibition of hemagglutination.
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  • Resultat 1-3 av 3

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