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Träfflista för sökning "WFRF:(Huong Dinh Xuan) "

Sökning: WFRF:(Huong Dinh Xuan)

  • Resultat 1-4 av 4
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1.
  • Phu, Vu Dinh, et al. (författare)
  • Ventilator-associated respiratory infection in a resource-restricted setting: impact and etiology
  • 2017
  • Ingår i: Journal of Intensive Care. - : BioMed Central (BMC). - 2052-0492. ; 5
  • Tidskriftsartikel (refereegranskat)abstract
    • Ventilator-associated respiratory infection (VARI) is a significant problem in resource-restricted intensive care units (ICUs), but differences in casemix and etiology means VARI in resource-restricted ICUs may be different from that found in resource-rich units. Data from these settings are vital to plan preventative interventions and assess their cost-effectiveness, but few are available.
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2.
  • Gordi, Toufigh, et al. (författare)
  • Artemisinin pharmacokinetics and efficacy in uncomplicated-malaria patients treated with two different dosage regimens.
  • 2002
  • Ingår i: Antimicrobial agents and chemotherapy. - 0066-4804. ; 46:4, s. 1026-31
  • Tidskriftsartikel (refereegranskat)abstract
    • The immediate efficacies of two oral dosage regimens of artemisinin were investigated in 77 male and female adult Vietnamese falciparum malaria patients randomly assigned to treatment with either 500 mg of artemisinin daily for 5 days (group A; n = 40) or artemisinin at a dose of 100 mg per day for 2 days, with the dose increased to 250 mg per day for 2 consecutive days and with a final dose of 500 mg on the fifth day (group B; n = 37). Parasitemia was monitored every 4 h. The average parasite clearance time was longer in group B than in group A (means +/- standard deviations, 50 +/- 23 and 34 +/- 14 h, respectively; P < 0.01). Artemisinin concentrations in saliva samples obtained on days 1 and 5 were quantified by high-performance liquid chromatography. The average oral clearance, based on saliva drug concentrations in group B patients, was twofold higher than that in group A patients on day 1 (P < 0.01), with no differences in drug half-lives (P = 0.40), indicating a saturable first-pass metabolism. Female patients had higher oral clearance values on day 1. Artemisinin's pharmacokinetic parameters were similar on day 5 in both groups, although a significant increase in oral clearance from day 1 to day 5 was evident. Thus, artemisinin exhibited both dose- and time-dependent pharmacokinetics. The escalating dose studied did not result in higher artemisinin concentrations toward the end of the treatment period.
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3.
  • Simonsson, Ulrika S H, et al. (författare)
  • Artemisinin autoinduction is caused by involvement of cytochrome P450 2B6 but not 2C9.
  • 2003
  • Ingår i: Clinical pharmacology and therapeutics. - 0009-9236 .- 1532-6535. ; 74:1, s. 32-43
  • Tidskriftsartikel (refereegranskat)abstract
    • Our goal was to investigate whether artemisinin autoinduction is caused by an increase in cytochrome P450 (CYP) 2B6 or CYP2C9 activities, we evaluated the effects of multiple-dose artemisinin administration on S-mephenytoin N-demethylation in healthy subjects.
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4.
  • Abbafati, Cristiana, et al. (författare)
  • 2020
  • Tidskriftsartikel (refereegranskat)
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  • Resultat 1-4 av 4

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