| 1. |
- Clark, DW, et al.
(författare)
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Associations of autozygosity with a broad range of human phenotypes
- 2019
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 4957-
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Tidskriftsartikel (refereegranskat)abstract
- In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: FROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44–66%] in the odds of having children. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in FROH is independent of all environmental confounding.
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| 2. |
- Ezzahi, A., et al.
(författare)
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X-ray diffraction and Raman spectroscopy studies of BaSrMWO6 (M=Ni, Co, Mg) double perovskite oxides
- 2011
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Ingår i: Journal of Molecular Structure. - : Elsevier BV. - 0022-2860 .- 1872-8014. ; 985:2-3, s. 339-345
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Tidskriftsartikel (refereegranskat)abstract
- In this work we report on the crystal structure and Raman spectroscopy of BaSrMWO6 (M=Ni, Co, Mg) double perovskite oxides. The results showed that the Ni, Co and Mg containing compounds crystallize in a cubic system with the space group Fm-3 in. The double perovskite structure can be represented as a three-dimensional network of alternating MO6 and WO6 octahedra, with Ba- and Sr-atoms occupying the interstitial spaces. The Raman spectra of this crystalline perovskite oxides are interpreted by means of factor group analysis in terms of space group Fm-3 m. Assignments of the W-O vibrational stretching and bending modes have been made. High temperature Raman spectroscopy of BaSrNiWO6 showed that all lattice modes illustrate a linear decrease in wavenumbers while temperature is increased. No discontinuities, in the temperature changes, in wavenumber observed for all modes recorded: indicating that the structure remains cubic and stable up the highest temperature studied here.
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| 3. |
- Manoun, B., et al.
(författare)
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High temperature induced phase transitions in Sr2ZnWO6 and Sr2CoWO6 double perovskite oxides : Raman spectroscopy as a tool
- 2012
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Ingår i: Journal of Molecular Structure. - : Elsevier BV. - 0022-2860 .- 1872-8014. ; 1029, s. 81-85
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Tidskriftsartikel (refereegranskat)abstract
- In this paper we report high-temperature (up to 550 °C) Raman spectroscopy of phase transitions in Sr2MWO6 (M = Zn, Co) double perovskite oxides. For Sr2ZnWO6 modes centered at 137 cm−1, 152 cm−1, merge around 80 °C. The same behavior was observed for the 436 cm−1 and 447 cm−1 modes. The mode centered at 854 cm−1 shows a change in the slope at the same temperature, thus indicating a first order phase transition from the monoclinic (P21/n) to tetragonal (I4/m) structure. With increasing temperature, a little change in the slope of the temperature dependence of mode centered at 855 cm−1 is observed around 480 °C which might be a sign of the second phase transition in Sr2ZnWO6 (tetragonal (I4/m) to cubic (Fm-3m)). The temperature dependence of the full width at half maximum (FWHM) of the most intense modes in Sr2ZnWO6 spectra was studied. The width behaves linearly as a function of temperature with a break observed in the slope of the width of the modes at 80 °C; thus, showing the first phase transition occurrence. For Sr2CoWO6 the transition from tetragonal (I4/m) structure to cubic (Fm-3m) phase is accompanied by considerable changes in the temperature dependence of modes centered at 438 cm−1 and 845 cm−1. The transition was observed around 420 °C.
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| 4. |
- Manoun, Bouchaib, et al.
(författare)
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High Temperature Raman Spectroscopy studies of the phase transitions in Sr2NiWO6 and Sr2MgWO6 double perovskite oxides
- 2010
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Ingår i: Journal of Molecular Structure. - : Elsevier BV. - 0022-2860 .- 1872-8014. ; 971:1-3, s. 18-22
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, we report on high temperature Raman spectroscopy studies (up to 550 °C) of the phase transitions in Sr2BWO6 (B = Ni, Mg) double perovskite oxides. For both compounds, the transition from the tetragonal (I4/m) phase to the cubic (Fm-3m) phase is accompanied by considerable changes in the temperature dependence of the modes. To better view this phase transition, the FWHM temperature dependence of the most intense modes were studied; by this study, we have obtained a sensitive guide to the onset of the phase transition. A large increase of the FWHM with increasing temperature is observed for all modes in the spectrum, clear transitional effects were observed: the width behaves in a linear way as a function of temperature; when the temperature reached around 300 °C, a drop in the width of this mode was observed; thus, showing the phase transition occurrence for both compounds. This drop is much more illustrated in Ni-containing compound than in Sr2MgWO6.
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| 5. |
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| 6. |
- Manoun, Bouchaib, et al.
(författare)
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X-ray diffraction and Raman spectroscopy studies of temperature and composition induced phase transitions in Ba2-xSrxMWO6 (M = Ni, Co and 0 <= x <= 2) double perovskite oxides
- 2013
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Ingår i: Journal of Molecular Structure. - : Elsevier BV. - 0022-2860 .- 1872-8014. ; 1045, s. 1-14
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Tidskriftsartikel (refereegranskat)abstract
- X-ray diffraction and Raman spectroscopy studies of Sr doped double perovskites compound Ba2-xSrxMWO6 with (M = Ni, Co and 0 <= x <= 2) were investigated. The samples show a transition from cubic to tetragonal phase as a function of composition while increasing strontium amount; both Rietveld refinements and Raman studies showed that this transition occurs between x = 1.2 and 1.4. Furthermore, increasing temperature for the tetragonal compositions (1.4 <= x <= 2), manifest the tetragonal to cubic phase transition. For this series, the transition from tetragonal (I4/m)/to cubic (Fm-3m) shows considerable changes in the composition and temperature dependence of the modes: all the Raman modes show a linear behavior when temperature is increased, then the slope change dramatically indicating the symmetry change from tetragonal to cubic. To better view this phase transition, the full width at half maximum (FWHM) temperature dependence of the most intense modes were studied; by this study, we have obtained a sensitive guide to the onset of the phase transition. A large increase of the FWHM with increasing temperature is observed for all modes in the spectrum, clear transitional effects were observed: the width behaves in a linear way as a function of temperature; when the temperature reached the transition temperature, a drop in the width of this mode was observed.
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| 7. |
- Manoun, Bouchaib, et al.
(författare)
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X-ray diffraction and Raman spectroscopy studies of temperature and composition induced phase transitions in Ba2-xSrxZnWO6 (0 <= x <= 2) double perovskite oxides
- 2012
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Ingår i: Journal of Alloys and Compounds. - : Elsevier BV. - 0925-8388 .- 1873-4669. ; 533, s. 43-52
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Tidskriftsartikel (refereegranskat)abstract
- X-ray diffraction and Raman spectroscopy studies of Sr doped double perovskites compound Ba2-xSrxZnWO6 with (0 <= x <= 2) were investigated. As a function of composition while increasing strontium amount, the samples show two phase transitions from cubic to tetragonal phase and from tetragonal to monoclinic structure. Both Rietveld refinements and Raman studies showed that the first phase transition occurs between x = 1 and 1.2; the second phase transition is observed around x = 2. Furthermore, increasing the temperature for the compositions (1.2 <= x <= 2), manifests the tetragonal to cubic phase transition. For x = 2 two phase transitions were observed as a function of temperature. For this series, the phase transitions are illustrated by considerable changes in the composition and temperature dependence of the modes. All the Raman modes show a linear behavior when the composition or temperature is increased, then the slope change indicating the symmetry change.
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| 8. |
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| 9. |
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