SwePub - sökning: WFRF:(Incedal Nilsson Ceren)

Numrering	Referens	Omslagsbild	Hitta
1.	Idevall Hagren, Olof, 1980-, et al. (författare) Keeping pace : the primary cilium as the conducting baton of the islet 2024 Ingår i: Diabetologia. - : Springer. - 0012-186X .- 1432-0428. ; 67, s. 773-782 Forskningsöversikt (refereegranskat)abstract Primary cilia are rod-like sensory organelles that protrude from the surface of most mammalian cells, including the cells of the islet, and mounting evidence supports important roles of these structures in the regulation of beta cell function and insulin secretion. The sensory abilities of the cilium arise from local receptor activation that is coupled to intrinsic signal transduction, and ciliary signals can propagate into the cell and influence cell function. Here, we review recent advances and studies that provide insights into intra-islet cues that trigger primary cilia signalling; how second messenger signals are generated and propagated within cilia; and how ciliary signalling affects beta cell function. We also discuss the potential involvement of primary cilia and ciliary signalling in the development and progression of type 2 diabetes, identify gaps in our current understanding of islet cell cilia function and provide suggestions on how to further our understanding of this intriguing structure.

Idevall Hagren, Olof, 1980-, et al. (författare)
Keeping pace : the primary cilium as the conducting baton of the islet
2024
Ingår i: Diabetologia. - : Springer. - 0012-186X .- 1432-0428. ; 67, s. 773-782
Forskningsöversikt (refereegranskat)abstract
- Primary cilia are rod-like sensory organelles that protrude from the surface of most mammalian cells, including the cells of the islet, and mounting evidence supports important roles of these structures in the regulation of beta cell function and insulin secretion. The sensory abilities of the cilium arise from local receptor activation that is coupled to intrinsic signal transduction, and ciliary signals can propagate into the cell and influence cell function. Here, we review recent advances and studies that provide insights into intra-islet cues that trigger primary cilia signalling; how second messenger signals are generated and propagated within cilia; and how ciliary signalling affects beta cell function. We also discuss the potential involvement of primary cilia and ciliary signalling in the development and progression of type 2 diabetes, identify gaps in our current understanding of islet cell cilia function and provide suggestions on how to further our understanding of this intriguing structure.

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