| 1. |
- Parker, James, 1980-, et al.
(författare)
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Is self-determined motivation associated with the effects of an intervention aimed to increase physical activity and exercise levels? An 80-day follow-up
- 2019
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Ingår i: Abstract book for the ISBNPA 2019 Annual Meeting in Prague. - London, UK : International Society of Behavioral Nutrition and Physical Activity. - 9781732401112 ; , s. 488-488
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Konferensbidrag (refereegranskat)abstract
- Objective: State-of-the-art technologies, for instance smart watches and smartphones, have the potential to positively influence physical activity and exercise in sedentary populations. Psychological factors, such as self-determined (SD) motivation, might influence the impact state-of-the-art technologies have on level of physical activity and exercise. The aim of this study was to investigate if self-determined motivation influences an intervention on both physical activity (PA) and exercise in a sedentary population.Methods: 16 participants (men = 5, women = 11) with a self-reported low level of PA over the last year and predominantly sedentary jobs volunteered to participate in the study. PA data (steps and exercise time) were collected over an 80-day period using a wrist-worn accelerometer (Apple-watch and iPhone). Motivation was measured with the Behavioral Regulation in Exercise Questionnaire-2. At the start of the study, each participant completed the questionnaire and received their Apple-watches. Data analysis: All PA and exercise data were recorded through the Apple-watch and via Health App. Data for PA (steps) and exercise time were then extracted and aggregated to daily totals. Statistical analysis: Group means and standard deviations were calculated. A linear regression analysis was used to analyze the relationship between exercise time, PA, and SD, the R2 value effect size (ES) was used to estimate the magnitude of the differences. All data analyses were performed in MatLab (software, R2016b).Results/findings: SD motivation (3.9±0.9) had a medium (R2 = 0.09) but not statistically significant (p = .26) effect on the amount of moderate to high-intensity exercise time (33.3±39.6 minutes) during the 80-day period. There was no statistically significant effect (R2 = 0.003, p = .84) of SD on PA (12953±7717 steps).Conclusions: Given the small sample size, achieving a medium effect size has meaningful significance despite not achieving statistical significance. This result suggests that self-determined motivation effects the amount of daily exercise but not PA in a sedentary population. Combining technology and other strategies (e.g., motivational interviewing, coaching) to promote behavior change is promising, and these interventions should include theoretically derived behavior change techniques and take level of SD motivation into account.
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| 2. |
- Aad, G., et al.
(författare)
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Identification and energy calibration of hadronically decaying tau leptons with the ATLAS experiment in pp collisions at root s=8 TeV
- 2015
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 75:7
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Tidskriftsartikel (refereegranskat)abstract
- This paper describes the trigger and offline reconstruction, identification and energy calibration algorithms for hadronic decays of tau leptons employed for the data collected from pp collisions in 2012 with the ATLAS detector at the LHC center-of-mass energy root s = 8 TeV. The performance of these algorithms is measured in most cases with Z decays to tau leptons using the full 2012 dataset, corresponding to an integrated luminosity of 20.3 fb(-1). An uncertainty on the offline reconstructed tau energy scale of 2-4%, depending on transverse energy and pseudorapidity, is achieved using two independent methods. The offline tau identification efficiency is measured with a precision of 2.5% for hadronically decaying tau leptons with one associated track, and of 4% for the case of three associated tracks, inclusive in pseudorapidity and for a visible transverse energy greater than 20 GeV. For hadronic tau lepton decays selected by offline algorithms, the tau trigger identification efficiency is measured with a precision of 2-8%, depending on the transverse energy. The performance of the tau algorithms, both offline and at the trigger level, is found to be stable with respect to the number of concurrent proton-proton interactions and has supported a variety of physics results using hadronically decaying tau leptons at ATLAS.
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| 5. |
- Abulaiti, Yiming, et al.
(författare)
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Centrality, rapidity, and transverse momentum dependence of isolated prompt photon production in lead-lead collisions at root S-NN=2.76 TeV measured with the ATLAS detector
- 2016
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Ingår i: Physical Review C. - : American Physical Society. - 2469-9985. ; 93:3
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Tidskriftsartikel (refereegranskat)abstract
- Prompt photon production in root S-NN = 2.76-TeV Pb + Pb collisions has been measured by the ATLAS experiment at the Large Hadron Collider using data collected in 2011 with an integrated luminosity of 0.14 nb(-1). Inclusive photon yields, scaled by the mean nuclear thickness function, are presented as a function of collision centrality and transverse momentum in two pseudorapidity intervals, vertical bar eta vertical bar < 1.37 and 1.52 <= vertical bar eta vertical bar < 2.37. The scaled yields in the two pseudorapidity intervals, as well as the ratios of the forward yields to those at midrapidity, are compared to the expectations from next-to-leading-order perturbative QCD (pQCD) calculations. The measured cross sections agree well with the predictions for proton-proton collisions within statistical and systematic uncertainties. Both the yields and the ratios are also compared to two other pQCD calculations, one which uses the isospin content appropriate to colliding lead nuclei and another which includes nuclear modifications to the nucleon parton distribution functions.
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| 6. |
- Ahlström, Christer, et al.
(författare)
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Performance of a one-camera and a three-camera system
- 2010
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Driving and operating a vehicle is to a great extent a visual task. In driver behaviour studies it is therefore important to be able to measure where the driver is looking. Today this can be done unobtrusively and remotely in real-time with camera based eye tracking. The most common remote eye tracking systems use multiple cameras in order to give satisfactory results. However, promising results using only one camera has recently emerged on the market. The main objective of this study is to compare eye tracking systems with one and three cameras, respectively, during various measurement conditions.A total of 53 participants were enrolled in the study. Data from the two eye trackers were acquired and analysed in terms of availability, accuracy and precision. The results indicate that both availability and accuracy are affected by many different factors. The most important factors are the number of cameras that is used and the angular distance from straight ahead. In the central region (straight ahead) both one-camera and three-camera systems have a high degree of accuracy and availability, but with increasing distance from the central region, the results deteriorate. This effect falls harder upon the one-camera system. Interestingly, there were no significant effects when wearing glasses in either availability or accuracy. There was however an interaction effect between distance and glasses.Advantages with a one-camera system are that it is cheaper, easier to operate and easier to install in a vehicle. A multi-camera system will, on the other hand, provide higher availability and accuracy for areas that are far from the road centre. A one-camera system is thus mostly suitable for in-vehicle applications such as systems that warn drivers for sleepiness or distraction while multi-camera solutions are preferable for research purposes.
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| 7. |
- Banjop-Kharlygdoh, Joubert, 1982-, et al.
(författare)
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Identification of a group of brominated flame retardants as novel androgen receptor antagonists and potential neuronal and endocrine disrupters
- 2015
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Ingår i: Environment International. - : Elsevier BV. - 0160-4120 .- 1873-6750. ; 74, s. 60-70
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Tidskriftsartikel (refereegranskat)abstract
- Brominated flame-retardants (BFRs) are used in industrial products to reduce the risk of fire. However, their continuous release into the environment is a concern as they are often persistent, bioaccumulating and toxic. Information on the impact these compounds have on human health and wildlife is limited and only a few of them have been identified to disrupt hormone receptor functions. In the present study we used in silico modeling to determine the interactions of selected BFRs with the human androgen receptor (AR). Three compounds were found to dock into the ligand-binding domain of the human AR and these were further tested using in vitro analysis. Allyl 2,4,6-tribromophenyl ether (ATE), 2-bromoallyl 2,4,6-tribromophenyl ether (BATE) and 2,3-dibromopropyl-2,4,6-tribromophenyl ether (DPTE) were observed to act as AR antagonists. These BFRs have recently been detected in the environment, in house dust and in aquatic animals. The compounds have been detected at high concentrations in both blubber and brain of seals and we therefore also assessed their impact on the expression of L-type amino acid transporter system (LAT) genes, that are needed for amino acid uptake across the blood-brain barrier, as disruption of LAT gene function has been implicated in several brain disorders. The three BFRs down-regulated the expression of AR target genes that encode for prostate specific antigen (PSA), 5. α-reductases and β-microseminoprotein. The potency of PSA inhibition was of the same magnitude as the common prostate cancer drugs, demonstrating that these compounds are strong AR antagonists. Western blot analysis of AR protein showed that ATE, BATE and DPTE decreased the 5. α-dihydrotestosterone-induced AR protein levels, further confirming that these BFRs act as AR antagonists. The transcription of the LAT genes was altered by the three BFRs, indicating an effect on amino-acid uptake across cellular membranes and blood-brain barrier. This study demonstrated that ATE, BATE and DPTE are potent AR antagonists and the alterations in LAT gene transcription suggest that these compounds can affect neuronal functions and should be considered as potential neurotoxic and endocrine disrupting compounds.
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| 8. |
- Bolin, David, 1983, et al.
(författare)
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Functional ANOVA modelling of pedestrian counts on streets in three European cities
- 2021
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Ingår i: Journal of the Royal Statistical Society. Series A, (Statistics in Society). - : Oxford University Press (OUP). - 1467-985X .- 0964-1998. ; 184:4, s. 1176-1198
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Tidskriftsartikel (refereegranskat)abstract
- The relation between pedestrian flows, the structure of the city and the street network is of central interest in urban research. However, studies of this have traditionally been based on small data sets and simplistic statistical methods. Because of a recent large-scale cross-country pedestrian survey, there is now enough data available to study this in greater detail than before, using modern statistical methods. We propose a functional ANOVA model to explain how the pedestrian flow for a street varies over the day based on its density type, describing the nearby buildings, and street type, describing its role in the city’s overall street network. The model is formulated and estimated in a Bayesian framework using hour-by-hour pedestrian counts from the three European cities, Amsterdam, London and Stockholm. To assess the predictive power of the model, which could be of interest when building new neighbourhoods, it is compared with four common methods from machine learning, including neural networks and random forests. The results indicate that this model works well but that there is room for improvement in capturing the variability in the data, especially between cities.
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| 9. |
- Cheviet, Severine, et al.
(författare)
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Tomosyn-1 is involved in a post-docking event required for pancreatic beta-cell exocytosis
- 2006
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Ingår i: Journal of Cell Science. - : The Company of Biologists. - 0021-9533 .- 1477-9137. ; 119:14, s. 2912-2920
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Tidskriftsartikel (refereegranskat)abstract
- Although the assembly of a ternary complex between the SNARE proteins syntaxin-1, SNAP25 and VAMP2 is known to be crucial for insulin exocytosis, the mechanisms controlling this key event are poorly understood. We found that pancreatic beta-cells express different isoforms of tomosyn-1, a syntaxin-1-binding protein possessing a SNARE-like motif. Using atomic force microscopy we show that the SNARE-like domain of tomosyn-1 can form a complex with syntaxin-1 and SNAP25 but displays binding forces that are weaker than those observed for VAMP2 (237 +/- 13 versus 279 +/- 3 pN). In pancreatic beta-cells tomosyn-1 was found to be concentrated in cellular compartments enriched in insulin-containing secretory granules. Silencing of tomosyn-1 in the rat beta-cell line INS-1E by RNA interference did not affect the number of secretory granules docked at the plasma membrane but led to a reduction in stimulus-induced exocytosis. Replacement of endogenous tomosyn-1 with mouse tomosyn-1, which differs in the nucleotide sequence from its rat homologue and escapes silencing, restored a normal secretory rate. Taken together, our data suggest that tomosyn-1 is involved in a post-docking event that prepares secretory granules for fusion and is necessary to sustain exocytosis of pancreatic beta-cells in response to insulin secretagogues.
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| 10. |
- Elmarghani, Ahmed, 1975-, et al.
(författare)
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Contribution of pharmaceuticals, fecal bacteria and endotoxin to the inflammatory responses to inland waters
- 2014
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Ingår i: Science of the Total Environment. - : Elsevier. - 0048-9697 .- 1879-1026. ; 488-489, s. 228-235
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Tidskriftsartikel (refereegranskat)abstract
- The increasing contamination of freshwater with pharmaceuticals, surfactants, pesticides and other organic compounds are of major concern. As these contaminants are detected at trace levels in the environment it is important to determine if they elicit biological responses at the observed levels. In addition to chemical pollutants, there is also a concern for increasing levels of bacteria and other microorganisms in freshwater systems. In an earlier study, we observed the activation of inflammatory systems downstream of a wastewater treatment plant (WWTP) in southern Sweden. We also observed that the water contained unidentified components that were pro-inflammatory and potentiated the immune response in human urinary bladder epithelial cells. In order to determine if these effects were unique for the studied site or represent a common response in Swedish water, we have now performed a study on three WWTPs and their recipient waters in central Sweden. Analysis of immune responses in urinary bladder epithelial cells, monocyte-like cells and blood mononuclear cells confirm that these waters activate the immune system as well as induce pro-inflammatory responses. The results indicate that the cytokine profiles correlate to the endotoxin load of the waters rather than to the levels of pharmaceuticals or culturable bacteria load, suggesting that measurements of endotoxin levels and immune responses would be a valuable addition to the analysis of inland waters.
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