| 1. |
- Bengtsson, Åsa, et al.
(författare)
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Naturreservatet Kullan : inventering av kärlväxter och naturvärdesbedömning
- 2007
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Ingår i: Tsunami. - 1651-5803. ; :1
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Olofströms kommun är på gång att starta ett ”Markernas museum” och i samband med detta fick vi i uppdrag av Olofströms kommun att inventera kärlväxterna i Kullans naturreservat. Detta tillsammans med en inventering av geologi som gjorts av Kamil Al-Ajely och de kulturella värdena som gjorts av Thomas Persson ska ligga som grund för ”Markernas museum”. Inventeringen till kommunen gjordes vid tre tillfällen, juni-augusti, 2005 och en rapport om detta lämnades in i september 2005 . Eftersom vi skulle ha material till vårt examensarbete har vi gjort ytterligare undersökningar än vad kommunen anvisade. Ytterligare en inventering har gjorts i maj 2006 för att få med vårväxterna. Naturreservatet Kullan är ett 41 ha stort område som blev naturreservat 2003. Den enda inventering som enligt uppgift gjorts är en artinventering från slutet av 1980-talet. Från denna ska det finnas en artlista, enligt inventeraren själv och länsstyrelsen, dock har det inte gått att få tag på den trots upprepade försök. Området som inventerats består av flera olika biotoper, ädellövskog, naturbetesmarker, kärr, slåtterängar och en sjö. Kullan har en lång kontinuitet som hävdad mark vilket ligger som grund för den stora artrikedomen. Det mesta av området har varit täckt av lövskog som förmodligen fungerat som betesmark ända fram till början av 1900-talet. Då ägdes gården av Åke och Bengta Svensson. Områdena runt sjön består av mosse eller kärr och i början av 1900-talet användes en del av våtmarkerna som åker. På kartan från 1915-17 ser man att sjön sänkts jämfört med föregående karta. Idag betas delar av området av 20-talet nötkreatur från vår till höst. Syfte och frågeställningarDen varierande omgivningen och det faktum att området hyser över 200 arter kärlväxter, gjorde att vi blev intresserade av att undersöka området. • Hur stora naturvärden finns här och hur skiljer sig vegetationen åt mellan de olika biotoperna?• Hur brukades Kullan under 1900-talet?• Hur såg markanvändningen ut under 1800-talet och hur har kontinuiteten av hävden sett ut?• Hur står sig Kullan jämfört med andra liknande områden?
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| 2. |
- Lundgren, Markus, et al.
(författare)
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Reduced morbidity at diagnosis and improved glycemic control in children previously enrolled in DiPiS follow-up
- 2014
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Ingår i: Pediatric Diabetes. - : Hindawi Limited. - 1399-543X. ; 15:7, s. 494-501
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Tidskriftsartikel (refereegranskat)abstract
- Aims/hypothesis: Children participating in longitudinal type 1 diabetes prediction studies were reported to have less severe disease at diabetes diagnosis. Our aim was to investigate children who from birth participated in the Diabetes Prediction in Skane (DiPiS) study for metabolic status at diagnosis and then continued to be followed for 2 yr of regular clinical care. Methods: Children, followed in DiPiS before diagnosis, were compared to children in the same birth cohort, who did not participate in follow-up. Metabolic status, symptoms at diagnosis as well as hemoglobin A1c (HbA1c) and doses of insulin at 3, 6, 12, and 24 months after diagnosis were compared. Results: Children, followed in DiPiS and diagnosed at 2-12 yr of age, had 0.8% (9 mmol/mol) lower HbA1c at diagnosis than those who were not followed (p=0.006). At diagnosis, fewer DiPiS children had symptoms (p=0.014) and ketoacidosis at diagnosis were reduced (2% compared to 18%, p=0.005). During regular clinical care, HbA1c levels for the DiPiS children remained lower both at 12 (0.4% (4 mmol/mol); p=0.009) and 24 months (0.8% (9 mmol/mol) p < 0.001) after diagnosis, despite no difference in total daily insulin between the two groups. Conclusions: Participation in prospective follow-up before diagnosis of type 1 diabetes leads to earlier diagnosis with fewer symptoms, decreased incidence of ketoacidosis as well as better metabolic control up to 2 yr after diagnosis. Our data indicate that metabolic control at the time of diabetes diagnosis is important for early metabolic control possibly affecting the risk of long-term complications.
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| 3. |
- Nived, Per, et al.
(författare)
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Methotrexate reduces circulating Th17 cells and impairs plasmablast and memory B cell expansions following pneumococcal conjugate immunization in RA patients
- 2021
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 11:1
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Tidskriftsartikel (refereegranskat)abstract
- Methotrexate (MTX) impairs antibody response after pneumococcal vaccination. We aimed to investigate differences in phenotypes of circulating B and T cells after pneumococcal conjugate vaccine (PCV) in rheumatoid arthritis (RA) patients on MTX (MTX group), RA without disease-modifying drugs (0DMARD), and controls (HC). MTX group (n = 11), 0DMARD (n = 12) and HC (n = 13) were studied. Blood samples were collected: before MTX, ≥ 4 weeks on stable MTX dose (prevaccination), and 7 days postvaccination (MTX group), and pre- and 7 days postvaccination (0DMARD and HC). Phenotypes of B- and T cell subsets were determined using flow cytometry. Serotype-specific IgG were quantified using multiplex bead assay, pre- and 4–6 weeks postvaccination. Concentrations of plasmablasts and switched memory B cells increased after PCV in HC (both p = 0.03) and the 0DMARD group (p = 0.01 and p = 0.02), but not in the MTX group. Postimmunization plasmablasts were lower in MTX group, compared to the 0DMARD group and HC (p = 0.002 and p < 0.001). Th17 cells decreased after MTX start (p = 0.02), and increased in HC after immunization (p = 0.01). Postimmunization plasmablasts correlated with mean antibody response ratio in all RA patients (R = 0.57, p = 0.035). Methotrexate reduced Th17 cells and blocked activation of plasmablasts and switched memory B cells following polysaccharide-protein conjugate antigen challenge in RA.
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| 6. |
- Becirovic-Agic, Mediha, et al.
(författare)
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Time course of decompensation after angiotensin II and high-salt diet in Balb/CJ mice suggests pulmonary hypertension-induced cardiorenal syndrome
- 2019
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Ingår i: American Journal of Physiology. Regulatory Integrative and Comparative Physiology. - : the American Physiological Society. - 0363-6119 .- 1522-1490. ; 316:5, s. R563-R570
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Tidskriftsartikel (refereegranskat)abstract
- The genetic background of a mouse strain determines its susceptibility to disease. C57BL/6J and Balb/CJ are two widely used inbred mouse strains that we found react dramatically differently to angiotensin II and high-salt diet (ANG II + Salt). Balb/CJ show increased mortality associated with anuria and edema formation while C57BL/6J develop arterial hypertension but do not decompensate and die. Clinical symptoms of heart failure in Balb/CJ mice gave the hypothesis that ANG II + Salt impairs cardiac function and induces cardiac remodeling in male Balb/CJ but not in male C57BL/6J mice. To test this hypothesis, we measured cardiac function using echocardiography before treatment and every day for 7 days during treatment with ANG II + Salt. Interestingly, pulsed wave Doppler of pulmonary artery flow indicated increased pulmonary vascular resistance and right ventricle systolic pressure in Balb/CJ mice, already 24 h after ANG II + Salt treatment was started. In addition, Balb/CJ mice showed abnormal diastolic filling indicated by reduced early and late filling and increased isovolumic relaxation time. Furthermore, Balb/CJ exhibited lower cardiac output compared with C57BL/6J even though they retained more sodium and water, as assessed using metabolic cages. Left posterior wall thickness increased during ANG II + Salt treatment but did not differ between the strains. In conclusion, ANG II + Salt treatment causes early restriction of pulmonary flow and reduced left ventricular filling and cardiac output in Balb/CJ, which results in fluid retention and peripheral edema. This makes Balb/CJ a potential model to study the adaptive capacity of the heart for identifying new disease mechanisms and drug targets.
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| 7. |
- Bengtsson Ryberg, Johanna, et al.
(författare)
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The Effects of Wind Power on Human Interests : A Synthesis
- 2013
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- PrefaceThere is a great need for knowledge concerning the impacts of wind power on humans, landscapes, the marine environment, birds, bats and other mammals.Previous studies of these environmental impacts have lacked an overall view of the effects. This has led to deficiencies in the processes surrounding the establishment of new wind farms. Vindval is a knowledge programme undertaken as a collaboration between the Swedish Energy Agency and the Swedish Environmental Protection Agency. Its aim is to gather and communicate scientific knowledge about the impacts of wind power on people and the natural environment. The programme continues until 2013.Vindval comprises some 30 individual research projects, together with four synthesis projects. Syntheses are prepared by experts, who compile and assess overall research results and experience regarding the effects of wind power in four different areas – humans, birds/bats, marine life and terrestrial mammals.The results of this research and synthesis work will provide a basis for environmental impact assessments and for the planning and permitting processes associated with wind power installations. Vindval requires high standards in the review and approval of research proposals, in order to ensure high-quality reports. The same high standards apply to the reporting, approval and publication of research results from the projects.This report was written by Johanna Bengtsson Ryberg, Gösta Bluhm, Karl Bolin, Bosse Bodén, Kristina Ek, Karin Hammarlund, Marianne Henningsson, Inga-Lena Hannukka, Carina Johansson, Sofia Jönsson, Sanna Mels, Tom Mels, Mats Nilsson, Erik Skärbäck, Patrik Söderholm, Åsa Waldo, Ingegärd Widerström, Niklas Åkerman.This report is a translation of the previous report in Swedish “Vindkraftens påverkan på människors intressen” (Naturvårdsverket report no 6497). Translated by Sofia Jönsson.The contents of the report are the responsibility of the authors.
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| 8. |
- Bergström, Åsa, et al.
(författare)
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Screening War and Peace: Newsreel Pragmatism in Neutral Sweden, September 1939 and May 1945
- 2018
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Ingår i: Researching Newsreels: Local, National and Transnational Case Studies / Chambers, Ciara, Jönsson, Mats, Vande Winkel, Roel (eds.). - Cham : Springer International Publishing - Palgrave Macmillan. - 9783319919195 ; , s. 157-182
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Bokkapitel (refereegranskat)abstract
- This volume addresses the underscrutinised topic of cinema newsreels. These short, multi-themed newsfilms, usually accompanied by explanatory intertitles or voiceovers, were a central part of the filmgoing experience around the world from 1910 through the late 1960s, and in many cases even later. As the only source of moving image news available before the widespread advent of television, newsreels are important social documents, recording what the general public was told and shown about the events and personalities of the day. Often disregarded as quirky or trivial, they were heavily utilised as propaganda vehicles, offering insights into the socio-political norms reflected in cinema during the first half of the twentieth century. The book presents a range of current research being undertaken in newsreel studies internationally and makes a case for a reconsideration of the importance of newsreels in the wider landscape of film history.
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| 9. |
- Bostanci, Nagihan, et al.
(författare)
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Label-free quantitative proteomics reveals differentially regulated proteins in experimental gingivitis
- 2013
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Ingår i: Journal of Proteome Research. - : American Chemical Society (ACS). - 1535-3893 .- 1535-3907. ; 2:12, s. 657-678
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Tidskriftsartikel (refereegranskat)abstract
- We investigated the sequential protein expression in gingival crevicular fluid samples during the induction (I) and resolution (R) of experimental gingivitis. Periodontally and systemically healthy volunteers (n = 20) participated in a three-week experimental gingivitis protocol, followed by debridement and two weeks of regular plaque control. Gingival crevicular fluid (GCF) samples were collected at baseline, Day 7, 14, and 21 (induction; I-phase), and at Day 21, 25, 30, and 35 (resolution; R-phase). Liquid chromatography-tandem mass spectrometry (LC-MS/MS) for label-free quantitative proteomics was applied. A total of 287 proteins were identified including 254 human, 14 bacterial, 12 fungal, and 7 yeast proteins. Ontology analysis revealed proteins primarily involved in cytoskeletal rearrangements, immune response, antimicrobial function, protein degradation, and DNA binding. There was considerable variation in the number of proteins identified, both among subjects and within subjects across time points. After pooling of samples between subjects at each time point, the levels of 59 proteins in the I-phase and 73 proteins in the R-phase were quantified longitudinally. Our data demonstrate that LC-MS/MS label-free quantitative proteomics is valuable in the assessment of the protein content of the GCF and can facilitate a better understanding of the molecular mechanisms involved in the induction and resolution of plaque-induced gingival inflammation in humans.
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| 10. |
- Cajander, Åsa, 1971-
(författare)
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Usability – Who Cares? : The Introduction of User-Centred Systems Design in Organisations
- 2010
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis analyses the difficulties encountered in the promotion of usability, especially in relation to occupation health issues, when developing IT systems in a public authority. It examines what happens when User-Centred Systems Design (UCSD) approaches are introduced to organisations with in-house systems development for their employees. It studies how stakeholder values affect the outcomes in terms of usability, occupational health, and institutional acceptance. Moreover, new methods are examined and evaluated as potential tools for assisting the adoption of UCSD. These methods are for example Field studies for system developers, Usability coaching for stakeholders and Management views of usability.A stated aim is to influence systems development in practice. Hence an action research paradigm has been employed, carrying out research and change in real life settings, gathering and analysing data using qualitative techniques.This thesis is based on a constructivist perspective, where theories in the areas of learning and organisational change have been used in order to better understand the research questions.The research demonstrates that most people are enthusiastic to, and interested in, UCSD with a focus on the computerised work environment. Many of the stakeholder groups, such as managers, users, project managers and system developers, changed their construct of identity as well as practice when UCSD was introduced.However, this research shows that there are several values that affect systems development and hinder usability work. These include for example value of rationality and objectivity, and differing values and perspectives underpinning descriptions and discourse on work and systems development. Values such as automation, efficiency, and customer satisfaction shape the development of new technology, and ultimately the tasks, work practices integrated in IT systems.Moreover, the results demonstrate that even though many consider usability as important, few take active responsibility for it, as the title of this thesis suggests.
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