| 1. |
- Jönsson, Lars-Eric, et al.
(författare)
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Arkitektur för en tom kaj
- 1999
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Ingår i: [Funktionalismen] Kring Kärnan. - 0440-663X. ; 28, s. 113-121
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Bokkapitel (populärvet., debatt m.m.)
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| 2. |
- Bauzá-Thorbrügge, Marco, et al.
(författare)
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Adipocyte-specific ablation of the Ca2+ pump SERCA2 impairs whole-body metabolic function and reveals the diverse metabolic flexibility of white and brown adipose tissue.
- 2022
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Ingår i: Molecular metabolism. - : Elsevier BV. - 2212-8778. ; 63
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Tidskriftsartikel (refereegranskat)abstract
- Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) transports Ca2+ from the cytosol into the endoplasmic retitculum (ER) and is essential for appropriate regulation of intracellular Ca2+ homeostasis. The objective of this study was to test the hypothesis that SERCA pumps are involved in the regulation of white adipocyte hormone secretion and other aspects of adipose tissue function and that this control is disturbed in obesity-induced type-2 diabetes.SERCA expression was measured in isolated human and mouse adipocytes as well as in whole mouse adipose tissue by Western blot and RT-qPCR. To test the significance of SERCA2 in adipocyte functionality and whole-body metabolism, we generated adipocyte-specific SERCA2 knockout mice. The mice were metabolically phenotyped by glucose tolerance and tracer studies, histological analyses, measurements of glucose-stimulated insulin release in isolated islets, and gene/protein expression analyses. We also tested the effect of pharmacological SERCA inhibition and genetic SERCA2 ablation in cultured adipocytes. Intracellular and mitochondrial Ca2+ levels were recorded with dual-wavelength ratio imaging and mitochondrial function was assessed by Seahorse technology.We demonstrate that SERCA2 is downregulated in white adipocytes from patients with obesity and type-2 diabetes as well as in adipocytes from diet-induced obese mice. SERCA2-ablated adipocytes display disturbed Ca2+ homeostasis associated with upregulated ER stress markers and impaired hormone release. These adipocyte alterations are linked to mild lipodystrophy, reduced adiponectin levels, and impaired glucose tolerance. Interestingly, adipocyte-specific SERCA2 ablation leads to increased glucose uptake in white adipose tissue while the glucose uptake is reduced in brown adipose tissue. This dichotomous effect on glucose uptake is due to differently regulated mitochondrial function. In white adipocytes, SERCA2 deficiency triggers an adaptive increase in fibroblast growth factor 21 (FGF21), increased mitochondrial uncoupling protein 1 (UCP1) levels, and increased oxygen consumption rate (OCR). In contrast, brown SERCA2 null adipocytes display reduced OCR despite increased mitochondrial content and UCP1 levels compared to wild type controls.Our data suggest causal links between reduced white adipocyte SERCA2 levels, deranged adipocyte Ca2+ homeostasis, adipose tissue dysfunction and type-2 diabetes.
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| 3. |
- Bernhardsson, Christian, et al.
(författare)
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Environmental radiation baseline around the Belarusian nuclear power plant – assessments in Belarus and Lithuania
- 2023
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Ingår i: Medical Physics in the Baltic States : Proceedings of the 16<sup>th</sup> International Conference on Medical Physics - Proceedings of the 16<sup>th</sup> International Conference on Medical Physics. - 1822-5721. ; , s. 121-125
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Konferensbidrag (refereegranskat)abstract
- Prior to the operation of the first Belarussian nuclear power plant (BelNPP), the baseline of the radiation environment was determined within a radius of about 30 km from BelNPP. This independent assessment was carried out during two expeditions in 2019. In 2022, a similar survey was carried out (during the initialoperation of BelNPP) on the Lithuanian side of the boarder. Here we present the overall project and some general results of the baseline assessments.
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| 4. |
- Bernhardsson, Christian, et al.
(författare)
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ZERO POINT ASSESSMENT OF THE RADIATION ENVIRONMENT – EXAMPLES OF A PROGRAM APPLIED IN SWEDEN (ESS) AND IN BELARUS (BELNPP)
- 2019
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Ingår i: MEDICAL PHYSICS IN THE BALTIC STATES : Proceedings of the 14th International Conference on Medical Physics - Proceedings of the 14th International Conference on Medical Physics. ; , s. 85-88
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Konferensbidrag (refereegranskat)abstract
- Before commissioning of a nuclear facility it is important to determine the baseline of the radiation environment. Such baseline or Zero Point assessments can only,and uniquely, be made before start of operation of the facility and will serve several purposes when the facility is in operation. Here we report on the planning and implementation of such a Zero Point program for achieving high reproducibility and effectiveness of the assessments around two nuclear installations.
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| 5. |
- Chimuka, Luke, et al.
(författare)
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Application of membrane-based extraction techniques to food and agricultural samples
- 2006
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Ingår i: Modern extraction techniques; food and agricultural samples (ACS symposium series). - 0097-6156. - 9780841239401 - 0841239401 ; 926, s. 149-162
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- The use of membrane-based extractions are increasingly seen as offering an alternative to conventional sample preparation procedures in analysis of chemical species in both food and agricultural samples. In this article, emphasis is placed on the attractiveness of membrane based extraction techniques to a variety of food and agricultural samples such as circulating nutrient solutions, fruit juices, fruits, beverages, vegetables, food oils and others. Examples of membrane based applications demonstrating how selective these techniques are even for food and agricultural samples are given.
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| 6. |
- Domeij, Maria, et al.
(författare)
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Utställningen Odens öga -att binda samman, transformera och visualisera
- 2006
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Ingår i: Odens öga - mellan människor och makter i det förkristna Norden.. - 1651-6796. - 9789197455053 - 9197455059 ; , s. 20-31
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Bokkapitel (populärvet., debatt m.m.)abstract
- Artikeln handlar om arbetet med utställningen Odens öga - mellan människor och makter i det förksristna Norden.
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| 7. |
- Eriksson Stenström, Kristina, et al.
(författare)
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Identifying radiologically important ESS-specific radionuclides and relevant detection methods
- 2020
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Bok (refereegranskat)abstract
- The European Spallation Source (ESS) is under construction in the outskirts of Lund in southern Sweden. When ESS has entered the operational phase in a few years, an intense beam of high-energy protons will not only produce the desired spallation neutrons from a large target of tungsten, but a substantial number of different radioactive by-products will also be generated. A small part of these will be released to the environment during normal operation. During an accident scenario, a wide range of gases and aerosols may be released from the tungsten target. The palette of radionuclides generated in the ESS target will differ from that of e.g. medical cyclotrons or nuclear power plants, thus presenting new challenges e.g. in the required environmental monitoring to ensure that dose limits to the public are not exceeded. This project (SSM2018-1636), financed by the Swedish Radiation Safety Authority (SSM), aimed to strengthen competence at Lund University for measurement and analysis of ESS-specific radionuclides. First, an extensive literature review, including modelling as well as experimental analyses, of ESS-relevant radionuclides was performed. We found that radionuclide production in particle accelerators is well-known, while experience with tungsten targets is very limited. As a second part of the project, an independent simplified model of the ESS target sector for the calculations of radionuclide production in the ESS tungsten target was developed using the FLUKA code. We conclude that we have a fairly good agreement with results of other authors, except for 148Gd, and that the calculated radionuclide composition is sensitive to the nuclear interaction models used.In the third part of the project, known environmental measurement technologies for various ESS-relevant radionuclides were reviewed, focussing on pure difficult-to-measure alpha- and beta-emitters. Liquid scintillation counting (LSC) is a suitable technique e.g. for the important beta emitters 3H, 14C, 35S, 31P and 33P. Several ESS radionuclides of relevance for dose estimates have never been investigated by environmental analytical techniques, due to their absence in the normal environment. Alpha spectrometry seems promising for the analysis of alpha-emitting lanthanides, in particular for 148Gd. Among the many types of mass spectrometry techniques, ICP-MS (inductively coupled plasma mass spectrometry) and AMS (accelerator mass spectrometry) seem to be the most suitable for the analysis of long-lived ESS radionuclides in environmental samples (e.g. 243Am and possibly lanthanides for ICP-MS and 10Be, 14C, 32Si, 36Cl, 60Fe and 129I for AMS).Three experimental parts were performed during the project, related to initiation of radioactivity measurements of aerosols at Lund University, mapping of environmental tritium in the Lund area, and establishment of a method to measure tritium in urine followed by a study of tritium in persons presently living or working in Lund. Aerosols were collected at a rural background station (Hyltemossa near Perstorp, northern Skåne) using a high-volume aerosol sampler with automatic filter change (DHA-80, Digitel). Gamma spectrometry measurements of 7Be agreed rather well with results from a nearby air monitoring station (SSM/FOI). Tritium (radioactive hydrogen) is expected to dominate the source term from the ESS target station to the environment. We have performed several investigations to monitor the current situation of tritium in Lund using LSC: the matrices investigated included air humidity, precipitation, pond water, indoor air at one accelerator facility and urine from the general public as well as from persons who may be occupationally exposed to tritium. Environmental tritium was generally very low (<3.4 Bq L-1), with somewhat higher concentration in the springtime than during the rest of the year. Tritium in the vast majority of the 55 urine samples was also very low: only a few exposed workers were found to have up to 11 Bq L-1 in their urine, which still is very low compared to e.g. reactor workers. Suggestions for further actions and work related to measurement and analysis of ESS relevant radionuclides are presented.
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| 8. |
- Eriksson Stenström, Kristina, et al.
(författare)
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PREOPERATIONAL ASSESSMENT OF 14C IN THE VINICINITY OF THE BELARUSIAN NUCLEAR POWER PLANT
- 2021
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Ingår i: Medical Physics in the Baltic States : Proceedings of the 15th International Conference - Proceedings of the 15th International Conference. - 1822-5721. ; , s. 133-137
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Konferensbidrag (refereegranskat)abstract
- As part of an independent assessment of the preoperational radiation environment around the Ostrovets nuclear power plant in Belarus, grass and foodstuffs were collected in 2019 for 14C analysis. The preoperational 14C specific activities in the Ostrovets region were shown to be similar to that of European data from other uncontaminated sites.
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| 9. |
- Gondo, Thamani Freedom, et al.
(författare)
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Extractability, selectivity, and comprehensiveness in supercritical fluid extraction of seaweed using ternary mixtures of carbon dioxide, ethanol, and water
- 2023
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Ingår i: Journal of chromatography. A. - 0021-9673. ; 1706, s. 464267-464267
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Tidskriftsartikel (refereegranskat)abstract
- It is well-known that an ideal extraction method enabling quantitative analysis should give complete extraction of the target analytes as well as minimal co-extraction of unwanted matrix substances. If the extraction method is part of a nontarget screening protocol, the desired analytes can differ widely in terms of chemical properties. In chromatography, terminologies such as recovery, selectivity, and comprehensiveness are well-established and can easily be determined. However, in extraction, these concepts are much less developed. Hence, the aim of our research is to develop and scrutinize theory in extraction with respect to numerical descriptors for extractability, selectivity, and comprehensiveness. Our approach is based on experiments determining the extractability of target analytes and selected interferences. As a case study, we use a pooled sample of three species of seaweed (Alaria esculenta, Laminaria digitata and Ascophyllum nodosum). Target analytes are β-carotene, fucoxanthin, δ-tocopherol, and phloroglucinol; and selected interferences are carbohydrates, proteins, ash, arsenic, and chlorophyll a. As a "green and clean" extraction technique, supercritical fluid extraction (SFE) using mixtures of CO 2, ethanol and water were explored using a design of experiment. The temperature was varied between 40-80°C, and the pressure was held constant at 300 bar. Obtained results clearly demonstrate that highest relative selectivity was achieved with CO 2 containing only 5 vol% of ethanol and no water, which primarily enabled high extractability of β-carotene, and yielding an extract free of carbohydrates, proteins, and toxic metals such as arsenic. Best methods for highest extractability of the other target analytes varied quite widely. Analytes requiring the highest water content (fucoxanthin and phloroglucinol), also resulted in the lowest relative selectivity. Maximum relative comprehensiveness was achieved using CO 2/ethanol/water (40/55/5, v/v/v) at 70°C and 300 bar. Our study demonstrates the feasibility of using relative quantitative descriptors for extractability, selectivity, and comprehensiveness, in optimization strategies for analytical extractions.
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| 10. |
- Hayes, Sandra Christine, et al.
(författare)
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The Effect of Exercise for the Prevention and Treatment of Cancer-Related Lymphedema : A Systematic Review with Meta-analysis
- 2022
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Ingår i: Medicine and Science in Sports and Exercise. - 0195-9131. ; 54:8, s. 1389-1399
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Forskningsöversikt (refereegranskat)abstract
- Introduction The purpose of this systematic review and meta-analysis was to evaluate the effects of exercise on (i) the prevention of cancer-related lymphedema (CRL) and (ii) the treatment of CRL, lymphedema-associated symptoms, and other health outcomes among individuals with CRL. Methods An electronic search was undertaken for exercise studies measuring lymphedema and involving individuals at risk of developing or with CRL. The Effective Public Health Practice Project Quality scale was used to assess study quality, and overall quality of evidence was assessed using the Grading of Recommendation, Assessment, Development and Evaluation approach. Meta-analyses were performed to evaluate effects of exercise on CRL incidence, existing CRL status, lymphedema-associated symptoms, and health outcomes. Results Twelve studies (n = 1955; 75% moderate-high quality) and 36 studies (n = 1741; 58% moderate-high quality) were included in the prevention and treatment aim, respectively. Relative risk of developing CRL for those in the exercise group compared with the nonexercise group was 0.90 (95% confidence interval (CI), 0.72 to 1.13) overall and 0.49 (95% CI, 0.28 to 0.85) for those with five or more lymph nodes removed. For those with CRL in the exercise group, the standardized mean difference (SMD) before to after exercise of CRL was-0.11 (95% CI,-0.22 to 0.01), and compared with usual care postintervention, the SMD was-0.10 (95% CI,-0.24 to 0.04). Improvements after intervention were observed for pain, upper-body function and strength, lower-body strength, fatigue, and quality of life for those in the exercise group (SMD, 0.3-0.8; P < 0.05). Conclusions Findings support the application of exercise guidelines for the wider cancer population to those with or at risk of CRL. This includes promotion of aerobic and resistance exercise, and not just resistance exercise alone, as well as unsupervised exercise guided by symptom response.
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