| 1. |
- Comasco, Erika, 1982-, et al.
(författare)
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Genetic and Functional Study of L-Type Amino Acid Transporter 1 in Schizophrenia
- 2017
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Ingår i: Neuropsychobiology. - Basel : S. Karger. - 0302-282X .- 1423-0224. ; 74:2, s. 96-103
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Tidskriftsartikel (refereegranskat)abstract
- Schizophrenia involves neural catecholaminergic dysregulation. Tyrosine is the precursor of catecholamines, and its major transporter, according to studies on fibroblasts, in the brain is the L-type amino acid transporter 1 (LAT1). The present study assessed haplotype tag single-nucleotide polymorphisms (SNPs) of the SLC7A5/LAT1 gene in 315 patients with psychosis within the schizophrenia spectrum and 233 healthy controls to investigate genetic vulnerability to the disorder as well as genetic relationships to homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG), the major catecholamine metabolites in the cerebrospinal fluid (CSF). Moreover, the involvement of the different isoforms of the system L in tyrosine uptake and LAT1 tyrosine kinetics were studied in fibroblast cell lines of 10 patients with schizophrenia and 10 healthy controls. The results provide suggestive evidence of individual vulnerability to schizophrenia related to the LAT1 SNP rs9936204 genotype. A number of SNPs were nominally associated with CSF HVA and MHPG concentrations but did not survive correction for multiple testing. The LAT1 isoform was confirmed as the major tyrosine transporter in patients with schizophrenia. However, the kinetic parameters (maximal transport capacity, affinity of the binding sites, and diffusion constant of tyrosine transport through the LAT1 isoform) did not differ between patients with schizophrenia and controls. The present genetic findings call for independent replication in larger samples, while the functional study seems to exclude a role of LAT1 in the aberrant transport of tyrosine in fibroblasts of patients with schizophrenia.
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| 2. |
- Jönsson, Anna Maria, et al.
(författare)
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Annual changes in MODIS vegetation indices of Swedish coniferous forests in relation to snow dynamics and tree phenology
- 2010
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Ingår i: Remote Sensing of Environment. - : Elsevier BV. - 0034-4257 .- 1879-0704. ; 114:11, s. 2719-2730
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Tidskriftsartikel (refereegranskat)abstract
- Remote sensing provides spatially and temporally continuous measures of forest reflectance, and vegetation indices calculated from satellite data can be useful for monitoring climate change impacts on forest tree phenology. Monitoring of evergreen coniferous forest is more difficult than monitoring of deciduous forest, as the new buds only account for a small proportion of the green biomass, and the shoot elongation process is relatively slow. In this study, we have analyzed data from 186 coniferous monitoring sites in Sweden covering boreal, southern-boreal, and boreo-nemoral conditions. Our objective was to examine the possibility to track seasonal changes in coniferous forests by time-series of MODIS eight-day vegetation indices, testing the coherence between satellite monitored vegetation indices (VI) and temperature dependent phenology. The relationships between two vegetation indices (NDVI and WDRVI) and four phenological indicators (length of snow season, modeled onset of vegetation period, tree cold hardiness level and timing of budburst) were analyzed. The annual curves produced by two curve fitting methods for smoothening of seasonal changes in NDVI and WDRVI were to a large extent characterized by the occurrence of snow, producing stable seasonal oscillations in the northern part and irregular curves with less pronounced annual amplitude in the southern part of the country. Measures based on threshold values of the VI-curves, commonly used for determining the timing of different phenological phases, were not applicable for Swedish coniferous forests. Evergreen vegetation does not have a sharp increase in greenness during spring, and the melting of snow can influence the vegetation indices at the timing of bud burst in boreal forests. However, the interannual variation in VI-values for specific eight-day periods was correlated with the phenological indicators. This relation can be used for satellite monitoring of potential climate change impacts on northern coniferous spring phenology. (C) 2010 Elsevier Inc. All rights reserved.
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| 3. |
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| 4. |
- Jönsson, Lars-Eric, et al.
(författare)
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Efterord
- 2006
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Ingår i: Det förflutnas närvaro. Essäer om norrländska kulturarv, historieskrivning och de andras spår. ; , s. 141-145
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 5. |
- Jönsson, Lars-Eric, et al.
(författare)
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Föreställd mångfald : Medborgarskap för framtiden
- 2017
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Ingår i: Politiska projekt, osäkra kulturarv : Kampanjer och förhandlingar i det sena 1900-talets Sverige och Europa - Kampanjer och förhandlingar i det sena 1900-talets Sverige och Europa. - 2001-7510 .- 2001-7529. - 9789198369014 ; 14, s. 113-130
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Bokkapitel (refereegranskat)
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| 6. |
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| 7. |
- Jönsson, Lars-Eric, et al.
(författare)
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Inledning
- 2008
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Ingår i: Kanon och kulturarv : Historia och samtid i Danmark och Sverige - Historia och samtid i Danmark och Sverige. - 1651-775X. - 9789170610509 ; 19, s. 7-15
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 8. |
- Jönsson, Lars-Eric, et al.
(författare)
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Landsbygdens landskap
- 2010
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Ingår i: Helsingborgs historia. Landsbygden. - 9789163363696 ; 8:1, s. 17-38
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 9. |
- Jönsson, Lars-Eric, et al.
(författare)
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Mitt och allas kulturarv : Politisk risk och resurs
- 2008
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Ingår i: Kanon och kulturarv : Historia och samtid i Danmark och Sverige - Historia och samtid i Danmark och Sverige. - 1651-775X. - 9789170610509 ; 19, s. 262-274
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 10. |
- Jönsson, Lars-Eric, et al.
(författare)
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Ord på vägen
- 2005
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Ingår i: I industrisamhällets slagskugga : om problematiska kulturarv (Dokumentation och forskning från Jämtlands läns museum). - 9172036729 ; , s. 8-24
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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