| 1. |
- Ahmed, Mobyen Uddin, Dr, 1976-, et al.
(författare)
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A Machine Learning Approach to Classify Pedestrians’ Event based on IMU and GPS
- 2019
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Ingår i: International Conference on Modern Intelligent Systems Concepts MISC'18. - : CESER Publications. ; 17:2, s. 154-167
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Konferensbidrag (refereegranskat)abstract
- This paper investigates and implements six Machine Learning (ML) algorithms, i.e. Artificial Neural Network (ANN), Support Vector Machine (SVM), Decision Tree (DT), Random Forest (RF), Extra Tree (ET), and Gradient Boosted Trees (GBT) to classify different Pedestrians’ events based on Inertial Measurement Unit (IMU) and Global Positioning System (GPS) signals. Pedestrians’ events are pedestrian movements as the first step of H2020 project called SimuSafe1 with a goal to reduce traffic fatalities by doing risk assessments of the pedestrians. The movements the MLs’ models are attempting to classify are standing, walking, and running. Data, i.e. IMU, GPS sensor signals and other contextual information are collected by a smartphone through a controlled procedure. The smartphone is placed in five different positions onto the body of participants, i.e. arm, chest, ear, hand and pocket. The recordings are filtered, trimmed, and labeled. Next, samples are generated from small overlapping sections from which time and frequency domain features are extracted. Three different experiments are conducted to evaluate the performances in term of accuracy of the MLs’ models in different circumstances. The best performing MLs’ models determined by the average accuracy across all experiments is Extra Tree (ET) with a classification accuracy of 91%.
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| 2. |
- Berggren, Magnus, et al.
(författare)
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Browsing the Real World using Organic Electronics, Si-Chips, and a Human Touch
- 2016
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Ingår i: Advanced Materials. - : Wiley. - 0935-9648 .- 1521-4095. ; 28:10, s. 1911-1916
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Tidskriftsartikel (refereegranskat)abstract
- Two different e-labels were developed to explore the feasibility and to identify scientifi c and engineering challenges of the Real-World-Web platform. First was a printed biosensor e-label, comprising Si-chips with an array of different printegrated devices, and second, an e-label to explore the feasibility of transferring data, through the human body, between a mobile device and different distributed e-labels, adhered onto the body or onto dedicated devices and surfaces of one's ambience. The silicon chips utilized in e-labels, include analogue and digital circuitry to receive and handle sensory input, to perform signal processing, and to transmit information to antennas and displays. When used, the e-label is turned on, and a sample is then added onto the sensor area. The display provides simple instructions and updated information to the user. All data handling, electrical probing, and analysis of the sensor is performed by the Si-chips, and the sensing data is finally shown in the printed display. The second e-label exemplifies an ID-tag for body area networks (BAN) communication applications, which, in part, is manufactured and integrated in the same way as the first e-label, but with another choice of Si-chips and capacitive antennas.
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| 3. |
- Corrales Duque, Carolina
(författare)
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Population Genetic Structure of Black Grouse (Tetrao tetrix) : From a Large to a Fine Scale Perspective
- 2011
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Black grouse (Tetrao tetrix) is a bird species with a lek mating system found in the Palearctic boreal taiga. It is assumed that it has a continuous distribution along Scandinavia and Siberia, whereas in Central Europe it has declined during the last decades. The primary objective of this thesis was to obtain a deeper understanding of the history, systematic classification and the genetic structure of black grouse on different geographical scales using microsatellites and control region mtDNA sequences (CR). I determined how much the mating system, habitat fragmentation and historical population processes have influenced the partitioning of genetic diversity in this species. Phylogeographical results are consistent with a demographic population expansion, and the patterns of postglacial dispersal suggest that a glacial refugium was located somewhere in central Asia, and from there black grouse spread out to Europe following the retreat of glacial ice sheets. I suggest that the two European black grouse subspecies, T. t. Tetrix and T. t. britannicus correspond to only one subspecies: T. t. tetrix, and that this lineage has diverged from T.t. viridanus, a subspecies found in Kazakhstan. The British population is significantly divergent from the remaining Eurasian samples for microsatellites but it is not for mtDNA. Therefore, they should regard as a separate Management Unit and not as a subspecies. Furthermore, British black grouse occur in three independent genetic units, corresponding to Wales, northern England/southern Scotland and northern Scotland. There was also genetic structure within Sweden. Habitat fragmentation is the main cause of population genetic structure in southern Swedish black grouse. In contrast, low levels of genetic differentiation and high connectivity were found in northern Sweden due to female-biased dispersal. On a finer geographical scale, I found genetic differences between leks due to a mixture of related and unrelated individuals within leks. However, mean relatedness values hardly differed from zero. Some leks were similar to one another and I interpret this as a result of variation in local reproductive success and philopatry. These factors would cause genetic structuring but this by itself would not reveal that kin selection is operating within black grouse leks.
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| 4. |
- Dash-Wagh, Suvarna, et al.
(författare)
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Intracellular Delivery of Short Interfering RNA in Rat Organ of Corti Using a Cell-penetrating Peptide PepFect6
- 2012
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Ingår i: Molecular Therapy Nucleic Acids. - : Elsevier BV. - 2162-2531. ; 1:e61
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Tidskriftsartikel (refereegranskat)abstract
- RNA interference (RNAi) using short interfering RNA (siRNA) is an attractive therapeutic approach for treatment of dominant-negative mutations. Some rare missense dominant-negative mutations lead to congenital-hearing impairments. A variety of viral vectors have been tested with variable efficacy for modulating gene expression in inner ear. However, there is concern regarding their safety for clinical use. Here, we report a novel cell-penetrating peptide (CPP)-based nonviral approach for delivering siRNA into inner ear tissue using organotypic cultures as model system. PepFect6 (PF6), a variant of stearyl-TP10, was specially designed for improved delivery of siRNA by facilitating endosomal release. We show that PF6 was internalized by all cells without inducing cytotoxicity in cochlear cultures. PF6/siRNA nanoparticles lead to knockdown of target genes, a housekeeping gene and supporting cell-specific connexin 26. Interestingly, application of PF6/connexin 26 siRNA exhibited knockdown of both connexin 26 and 30 mRNA and their absence led to impaired intercellular communication as demonstrated by reduced transfer of calcein among the PF6/connexin 26-siRNA-treated cells. Thus, we conclude that PF6 is an efficient nonviral vector for delivery of siRNA, which can be applied as a tool for the development of siRNA-based therapeutic applications for hearing impairments.
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| 5. |
- Halvarsson, Peter, 1976-
(författare)
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On the Effects of Blood Parasites in Wild Birds
- 2013
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Coccidian and haemoatozoan parasites are commonly occurring endo-parasites in wild birds and prevalence can vary among species and populations. In addition to prevalence studies, parasites are often used to investigate effects on life history traits. Findings from these studies are not unambiguous, as correlations with many life history traits are absent, although common findings include negative effects on survival and body condition. In this thesis, coccidian and blood parasite prevalence and their effect on survival were investigated using a PCR approach in eleven popu-lations of great snipes (Gallinago media) and in two populations of tree sparrows (Passer montanus). In great snipes and tree sparrows we investigated the parasites Plasmodium/Haemoproteus (P/H) and Leucocytozoon and in tree sparrows also Atoxoplasma.In Great snipes the overall adult prevalence was 29.9%. At the main study site, Gåvålia, Norway, a decrease in P/H prevalence with age was found and infected birds had a lower mean age. Two not mutually exclusive alternative explanations are that infected young birds may have a higher mortality and/or that individual birds can purge the infection. There was a variation in prevalence among the sample years in Gåvålia and a difference among populations. Finding fluctuations among year demonstrates the need of long term data to study parasite prevalence variation. In tree sparrows the Haematozoan prevalence was 5.9% in adults and 56.5% in Atoxoplasma. By using recapture models to estimate apparent survival rates with the software MARK 4.2, it was suggested that parasite infections may have an impact on the apparent survival rate in one of the populations. Since condition and breeding performance appeared unaffected, it can be hypothesised that this pattern may indicate that chronic infections generally do not appear to impair birds, although subclinical infections may occasionally develop into disease with fatal outcome.
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| 6. |
- Holmbring, Staffan, et al.
(författare)
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Elektronism : en flerårig resa genom tolv månader
- 2021
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Bok (populärvet., debatt m.m.)abstract
- Temat i boken Elektronism ligger i tiden. Staffan Holmbring och J Jacob Wikner gör en tidsresa genom året. Funderingar kopplas ihop med månadernas karaktär. Naturvetenskapliga och filosofiska tankar uppstår och läsaren får följa dem under tidsresans gång. Elektronism tar vid där vår frågvishet slutar. Holmbring och Wikner ställer frågor på ett enkelt vis. Varför är vatten blött? Varför blir det aldrig blötare av att vattna på vatten?Elektronism är en fristående fortsättning där den förra boken Elektrosofi slutade. Resan har nu fortsatt från geografiska stopp till stopp i vår kalender. Staffan Holmbring är teknisk doktor i tillämpad fysik från Linköpings universitet. Kompetensen han fick därifrån har han bland annat använt i de företag som han har drivit från 80-talet med verksamheter inom tillämpad fysik och integrerad elektronik. Mycket intresserar honom utanför det naturvetenskapliga skrået, främst litteratur, filosofi och bildkonst. J Jacob Wikner är uppväxt i Borgholm, Öland. Dagarna fylls ofta med föreläsningar, kretskonstruktion och forskningsprojekt som spänner från den afrikanska landsbygden via kroppens elektriska signaler till röntgendetektorer. Intressena för en teknisk doktor, docent och biträdande professor kan vara många.
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| 7. |
- Holmbring, Staffan, et al.
(författare)
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Elektrosofi : med avtryck från Öland
- 2019
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- "nedslag från en tankeväckande resa på Öland. Vilka funderingar kan kopplas ihop med de platser som författarna besöker under resans gång? Vi får följa de naturvetenskapliga såväl som filosofiska tankar som uppstår längs resans väg."
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| 8. |
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| 9. |
- Kowalewski, Jacob M., et al.
(författare)
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Disentangling Membrane Dynamics and Cell Migration; Differential Influences of F-actin and Cell-Matrix Adhesions
- 2015
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 10:8
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Tidskriftsartikel (refereegranskat)abstract
- Cell migration is heavily interconnected with plasma membrane protrusion and retraction (collectively termed membrane dynamics). This makes it difficult to distinguish regulatory mechanisms that differentially influence migration and membrane dynamics. Yet such distinctions may be valuable given evidence that cancer cell invasion in 3D may be better predicted by 2D membrane dynamics than by 2D cell migration, implying a degree of functional independence between these processes. Here, we applied multi-scale single cell imaging and a systematic statistical approach to disentangle regulatory associations underlying either migration or membrane dynamics. This revealed preferential correlations between membrane dynamics and F-actin features, contrasting with an enrichment of links between cell migration and adhesion complex properties. These correlative linkages were often nonlinear and therefore context-dependent, strengthening or weakening with spontaneous heterogeneity in cell behavior. More broadly, we observed that slow moving cells tend to increase in area, while fast moving cells tend to shrink, and that the size of dynamic membrane domains is independent of cell area. Overall, we define macromolecular features preferentially associated with either cell migration or membrane dynamics, enabling more specific interrogation and targeting of these processes in future.
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| 10. |
- Larsson, Kjell, 1958-, et al.
(författare)
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Population differentiation in the redshank (Tringa totanus) as revealed by mitochondrial DNA and amplified fragment length polymorphism markers
- 2005
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Ingår i: Conservation Genetics. - : Springer Science and Business Media LLC. - 1566-0621 .- 1572-9737. ; 6:3, s. 321-331
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Tidskriftsartikel (refereegranskat)abstract
- The redshank (Tringa totanus) is declining throughout Europe and to implement efficient conservation measures, it is important to obtain information about the population genetic structure. The aim of the present study was two-fold. First, we analysed the genetic variation within and between populations in the Baltic region in southern Scandinavia. Evidence of genetic structure would suggest that different populations might require separate management strategies. Second, in an attempt to study large-scale genetic structure we compared the Baltic populations with redshanks from northern Scandinavia and Iceland. This analysis could reveal insights into phylogeography and long-term population history. DNA samples were collected from six breeding sites in Scandinavia presumed to include two subspecies (totanus and britannica) and a further sample from Iceland (subspecies robusta). Two methods were used to study the population genetic structure. Domain II and III of the mitochondrial control region was analysed by DNA sequencing and nuclear DNA was analysed by screening amplified fragment length polymorphism (AFLP) markers. Mitochondrial DNA showed no variation between individuals in domain II. When analysing an 481 bp fragment of domain III seven haplotypes were found among birds. On the basis of mtDNA sequences, redshanks showed some evidence of a recent expansion from a bottlenecked refugial population. Bayesian analyses of AFLP data revealed a significant genetic differentiation between suggested subspecies but not between populations within the Baltic region. Our results indicate that populations of redshanks in Europe constitute at least three separate management units corresponding to the recognised subspecies.
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