| 1. |
- Alexander, Stephen P. H., et al.
(författare)
-
The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors
- 2023
-
Ingår i: BRITISH JOURNAL OF PHARMACOLOGY. - : British pharmacological society. - 0007-1188 .- 1476-5381. ; 180
-
Tidskriftsartikel (refereegranskat)abstract
- The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at . G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
|
|
| 2. |
- Bjuhr, Marie, et al.
(författare)
-
Women with disturbed eating behavior rate less work engagement
- 2016
-
Konferensbidrag (refereegranskat)abstract
- There is a lack of research exploring emotional commitment to work in relation to eating attitudes. Since eating disorders are associated with adverse psychological and social consequences, work engagement could be affected. The purpose was to compare work engagement among women with and without disturbed eating (DE).A cross-sectional survey using the Utrecht Work Engagement Scale and the Eating Disorder Examination Questionnaire in a general population cohort of 26-36-year-old women (n=847). Threshold for DE was 1 SD above general population mean. Independent t-test was used to compare work engagement. Ethical approval (reg no:2014/401)The level of work engagement was lower (p=0.02) among women with DE (mean 3.69 +-1.43) than women without DE (mean 4.06 +-1.18). The score for dedication was also lower (p=0.02) within the DE group (mean 3.74+-1.57 vs 4.22 +-1.26). However, vigour and absorption were not different.The work engagement in the cohort was within the average range although women with DE had significantly lower emotional commitment to work. As work engagement is linked to business success, workplace growth and sustainability it seems important to explore tailored strategies to improve work engagement among women with DE.
|
|
| 3. |
|
|
| 4. |
- Christopoulos, Arthur, et al.
(författare)
-
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors.
- 2021
-
Ingår i: British journal of pharmacology. - : Wiley. - 1476-5381 .- 0007-1188. ; 178 Suppl 1
-
Forskningsöversikt (refereegranskat)abstract
- The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.15538. G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
|
|
| 5. |
- Gustafsson, Mats, et al.
(författare)
-
Effekter av vinterdäck : en kunskapsöversikt
- 2006
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Choice of winter tyres has, from mainly being a matter of safety and economic costs for wearing of road pavements, during later years also become a matter of inhalable particles formed during pavement wear from studded tyres and their negative effects on public health. Further, the tyres' effects on environment and noise have been illustrated in several studies. The issue is also complicated by the fact that tyre choice effects on traffic safety have several components, including such diverging parameters as friction and behaviour. Finally all aspects have to be evaluated from a socioeconomic point of view for society to be able to decide which kind of distribution of tyre types that is the most profitable. This report is a summary of current knowledge in this complex research field.
|
|
| 6. |
|
|
| 7. |
- Hanson, Magnus, et al.
(författare)
-
Influence from tool roughness on the risk of work material adhesion and transfer
- 2008
-
Konferensbidrag (refereegranskat)abstract
- Influence from surface roughness of a forming tool surface on its ability to pick up work material was investigated by laboratory testing. One powder metallurgical tool steel was given different surface roughnesses and tested in sliding contact against one austenitic stainless steel (SS) and one aluminium alloy (Al). Generally, the risk of work material adhesion and transfer increased with the roughness of the tool material. However, SS gave a low friction and very little metal transfer for a tool roughness of the order of the relatively soft SS oxide thickness. The Al alloy, on the other hand, which oxide is much harder than the parent metal, has no critical surface roughness below which adhesive transfer will not occur. The oxide fractures and oxide fragments indent the tool surface increasing the risk of adhesion.
|
|
| 8. |
- Hanson, Magnus, et al.
(författare)
-
Influence from tool roughness on the risk of work material adhesion and transfer
- 2009
-
Ingår i: Materials and Manufacturing Processes. - : Informa UK Limited. - 1042-6914 .- 1532-2475. ; 24:7-8, s. 913-917
-
Tidskriftsartikel (refereegranskat)abstract
- Influence from surface roughness of a forming tool surface on its ability to pick up work material was investigated by laboratory testing. One powder metallurgical tool steel was given different surface roughnesses and tested in sliding contact against one austenitic stainless steel (SS) and one aluminium alloy (Al). Generally, the risk of work material adhesion and transfer increased with the roughness of the tool material. However, SS gave a low friction and very little metal transfer for a tool roughness of the order of the relatively soft SS oxide thickness. The Al alloy, on the other hand, which oxide is much harder than the parent metal, has no critical surface roughness below which adhesive transfer will not occur. The oxide fractures and oxide fragments indent the tool surface increasing the risk of adhesion.
|
|
| 9. |
- Heldin, Magnus, et al.
(författare)
-
On the critical roles of initial plastic deformation and material transfer on the sliding friction between metals
- 2021
-
Ingår i: Wear. - : Elsevier. - 0043-1648 .- 1873-2577. ; 477
-
Tidskriftsartikel (refereegranskat)abstract
- It is well known that the friction level rapidly shifts during the initial sliding between two unlubricated metals. Often this change is so rapid that the initial friction level is not even noticed, owing to initial surface contamination or roughening of the contacting surfaces, either due to plastic deformation and wear, or transfer. The present work uses a unique experimental set-up - the Uppsala Load Scanner - to generate detailed information on friction and surface modification in initial sliding contact between pairs of crossed metal cylinders. A wide range of loads, each exclusively coupled to a well-defined contact area on both contacting bodies, is evaluated in a single test. By performing repeated scans, intertwined with high resolution FEG-SEM studies of the contact surfaces, investigations of the couplings between local load, friction, surface modification, topography, transfer, etc. is facilitated and the progress of deformation and friction can be followed. The SEM studies also include local FIB cross sectioning of selected samples to learn more about the sub-surface modifications. The materials selected include a PM tool steel, a case-hardened component steel and an aluminium alloy. All tests were conducted in dry contact. The roles of the large initial surface roughening or flattening, the following material transfer and other gradual surface modifications in determining the friction level, are discussed.
|
|
| 10. |
- Huss, Magnus, et al.
(författare)
-
Experimental evidence of gradual size-dependent shifts in body size and growth of fish in response to warming
- 2019
-
Ingår i: Global Change Biology. - : Wiley. - 1354-1013 .- 1365-2486. ; 25, s. 2285-2295
-
Tidskriftsartikel (refereegranskat)abstract
- A challenge facing ecologists trying to predict responses to climate change is the few recent analogous conditions to use for comparison. For example, negative relationships between ectotherm body size and temperature are common both across natural thermal gradients and in small-scale experiments. However, it is unknown if short-term body size responses are representative of long-term responses. Moreover, to understand population responses to warming, we must recognize that individual responses to temperature may vary over ontogeny. To enable predictions of how climate warming may affect natural populations, we therefore ask how body size and growth may shift in response to increased temperature over life history, and whether short-and long-term growth responses differ. We addressed these questions using a unique setup with multidecadal artificial heating of an enclosed coastal bay in the Baltic Sea and an adjacent reference area (both with unexploited populations), using before-after control-impact paired time-series analyses. We assembled individual growth trajectories of similar to 13,000 unique individuals of Eurasian perch and found that body growth increased substantially after warming, but the extent depended on body size: Only among small-bodied perch did growth increase with temperature. Moreover, the strength of this response gradually increased over the 24 year warming period. Our study offers a unique example of how warming can affect fish populations over multiple generations, resulting in gradual changes in body growth, varying as organisms develop. Although increased juvenile growth rates are in line with predictions of the temperature-size rule, the fact that a larger body size at age was maintained over life history contrasts to that same rule. Because the artificially heated area is a contemporary system mimicking a warmer sea, our findings can aid predictions of fish responses to further warming, taking into account that growth responses may vary both over an individual's life history and over time.
|
|
