| 1. |
- Betsholtz, Alexander, et al.
(författare)
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Sewage sludge-based activated carbon – Production and potential in wastewater and stormwater treatment
- 2019
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- SummarySustainable sewage sludge management has been a heavily debated topic in Europe for more than a decade. Due to its content of pollutants such as heavy metals, pharmaceuticals and other organic micropollutants, the use of sewage sludge for farmland application is currently banned or restricted in most European countries. Therefore, alternative methods for sludge management are discussed. The production of sludge-based activated carbon (SBAC) from digested sewage sludge is an alternative that would make use of problematic waste—sewage sludge—to produce a potentially valuable adsorbent. In this study, SBAC has been reviewed based on its potential use as an adsorbent for pollutants in wastewater and stormwater. The study consists of a literature review targeting (i) different methods for SBAC production, (ii) the influence of the production methods on the physical and chemical properties of the activated carbons and (iii) the importance of physical and chemical carbon properties on the adsorption of various types of pollutants in aquatic solutions. In connection to the literature study, SBAC was produced in the laboratory using a one-step steam activation method in order to study how various production parameters, such as pyrolysis temperature and steam oxidation, affect the porosity development of SBAC. The porosity of the carbon was assessed using N2adsorption and desorption isotherms at 77 K. Several combinations of the decisive parameters at various levels were tested and consequently the steam activated SBAC with highest volume of micropores (and highest specific surface area) was selected and tested for the adsorption of chemical oxygen demand (COD) and inorganic nutrients (NH4+, NO3-and PO43-) in wastewater from Källby WWTP in Lund, Sweden. As a reference, the SBAC was compared with a commercial activated carbon (CAC), Norit Sae Super (from Cabot), with a BET surface area of 975 m2/g. The results from existing literature show that SBAC, due to their high inorganic content, in general exhibit low micropore volumes compared to CAC, and therefore also tend to have a lower adsorption potential for small organic substances. However, the larger pores of the SBAC might be advantageous for adsorption of large organic pollutants such as dyes. In addition, the inorganic content of SBAC may contribute to the adsorption of charged and/or hydrophilic substances that are adsorbed through chemical interactions with surface functional groups of the carbon, rather than by physical adsorption to the core carbon structure. With respect to SBAC production, both feedstock type (e.g. biological sludge vs. chemical sludge) and production method (chemical vs. physical activation) have large influence on the properties of the carbon. In general, chemical activation using strong acids or based tend to generate SBAC with higher micropore volumes and abundance of surface functional groups compared to physical activation methods (such as steam activation), although its applicability can be questioned due to the large required input of chemicals. The result from the laboratory studies show that steam activated SBAC with BET surface areas of up to 162 m2/g could be generated using one-step steam activation at 800 °C for 30 minutes, although activation parameters were not optimized with respect to maximum surface area generation. The adsorption experiments showed that CAC was much better at adsorbing COD in effluent wastewater compared to the steam activated SBAC produced in lab, especially at low carbon concentrations. The experiments further showed that neither CAC nor SBAC was successful in adsorbing large quantities of inorganic nutrients (NH4+, NO3-and PO43-), probably due to lack of charged surface functional groups. Much work remains in order to demonstrate large scale production of SBAC in order to evaluate the economic feasibility of the process. In connection, more work is needed to understand how to maximize the potential of SBAC for the uptake of specific substances such as heavy metals or hydrophilic micropollutants.
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| 2. |
- Hägglund, Moa, et al.
(författare)
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Accounting for bacterial overlap between raw water communities and contaminating sources improves the accuracy of signature-based microbial source tracking
- 2018
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Ingår i: Frontiers in Microbiology. - : Frontiers Media S.A.. - 1664-302X. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- Microbial source tracking (MST) analysis is essential to identifying and mitigating the fecal pollution of water resources. The signature-based MST method uses a library of sequences to identify contaminants based on operational taxonomic units (OTUs) that are unique to a certain source. However, no clear guidelines for how to incorporate OTU overlap or natural variation in the raw water bacterial community into MST analyses exist. We investigated how the inclusion of bacterial overlap between sources in the library affects source prediction accuracy. To achieve this, large-scale sampling-including feces from seven species, raw sewage, and raw water samples from water treatment plants - was followed by 16S rRNA amplicon sequencing. The MST library was defined using three settings: (i) no raw water communities represented; (ii) raw water communities selected through clustering analysis; and (iii) local water communities collected across consecutive years. The results suggest that incorporating either the local background or representative bacterial composition improves MST analyses, as the results were positively correlated to measured levels of fecal indicator bacteria and the accuracy at which OTUs were assigned to the correct contamination source increased fourfold. Using the proportion of OTUs with high source origin probability, underpinning a contaminating signal, is a solid foundation in a framework for further deciphering and comparing contaminating signals derived in signature-based MST approaches. In conclusion, incorporating background bacterial composition of water in MST can improve mitigation efforts for minimizing the spread of pathogenic and antibiotic resistant bacteria into essential freshwater resources.
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| 3. |
- Jacobsson, Mattias, et al.
(författare)
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Always-On + Adoption – a method for longitudinal studies
- 2012. - 5
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Konferensbidrag (refereegranskat)abstract
- We will discuss an approach for conducting long term studies of companionship technologies – technologies intended for more intimate relationships with people. We draw from our work of conducting several qualitative long-term user studies of people’s relationship with robotic companions and mobile devices in order to develop a methodology where the initial bond with the artifact is based on a more intense experience. After this initial phase referred to as Always On the relationship will fade over to the adoption phase where the more traditional long-term use can be studied. Most recently we are trying out this approach for studying people’s experience of an online social game that features virtual agents.
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| 4. |
- Jacobsson, Mattias, et al.
(författare)
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Mobile ActDresses : Programming mobile devices by accessorizing
- 2012
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Ingår i: Conf Hum Fact Comput Syst Proc. - New York, NY, USA : ACM. - 9781450310161 ; , s. 1071-1074
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Konferensbidrag (refereegranskat)abstract
- Mobile ActDresses is a design concept where existing practices of accessorizing, customization and manipulation of a physical mobile device is coupled with the behaviour of its software. With this interactivity demonstrator we will provide a hands on experience of doing this kind of playful manipulation. We provide two examples for how to implement Mobile ActDresses using quick'n dirty hacks to create custom shells and jewellery for controlling the behaviour of the phone.
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| 5. |
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| 7. |
- Lindegren, Stina, 1982-
(författare)
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Support and Treatment for Men Convicted of Sexual Offending : Readiness, Change, and Previous Help-Seeking
- 2024
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Social work plays a crucial role in the prevention of sexual abuse. Such prevention can involve protection for potential victims but also measures directed at those who perpetrate sexual abuse. However, research on desistance among those who have committed sexual offences, their treatment readiness, and help-seeking prior to conviction is scarce.This doctoral thesis aims to explore support and treatment from the perspective of adult men convicted of sexual offences in Sweden. What are their experiences of change after participation in sex offender treatment, and how do they engage in risk-reducing interventions? Particular attention is placed on the roles of relatives and society.Data consist of pre- and post-tests (n = 99) and in-depth interviews with men convicted of sexual crimes (n = 19). The interviews were carried out with both participants (n = 13) and non-participants (n = 6) in sex offender treatment.Participants’ self-reports (n ~ 26) and therapist ratings (n = 46) analysed in paper I suggest that participation in the sex offender programme called SEIF may be associated with changes in criminogenic needs, potentially reducing issues linked to recidivism. However, caution is advised due to methodological limitations. Further studies are needed to determine effectiveness. According to paper II, interviewees who participated in SEIF (n = 13) appeared to have started building new prosocial narrative identities, indicative of early desistance.The findings in paper III suggest that non-rehabilitative, punitive elements within correctional systems can create barriers to readiness. Nevertheless, supportive and non-punitive responses from staff, close ones, or fellow inmates seemed to counteract these negative loops. This hypothesised relational mechanism, promoting readiness, is termed looping disruption. Paper IV examines help-seeking behaviours and indicates that prevention efforts can either succeed or fail at various societal levels. Barriers to seeking help include a lack of awareness of the problem, fear of social consequences, and a neglectful welfare system. Professionals with specific knowledge and focus were seen as providing meaningful support, while the involvement of loved ones was a central motivator.In conclusion, a non-judgmental, person-centred, and supportive approach is recommended, as it seems to increase willingness to change. Professionals may need specific training to tackle the challenges associated with this task. Furthermore, the thesis highlights how the significant stigma associated with sexual offences is a major obstacle when reintegrating individuals convicted of such crimes into society.
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| 8. |
- Lövgren, Tanja, et al.
(författare)
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Complete and long-lasting clinical responses in immune checkpoint inhibitor-resistant, metastasized melanoma treated with adoptive T cell transfer combined with DC vaccination
- 2020
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Ingår i: Oncoimmunology. - : TAYLOR & FRANCIS INC. - 2162-4011 .- 2162-402X. ; 9:1
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Tidskriftsartikel (refereegranskat)abstract
- Development of T cell-directed immune checkpoint inhibitors (ICI) has revolutionized metastatic melanoma (MM) therapy, but <50% of treated patients experience durable responses. This phase I trial (NCT01946373) investigates the safety/feasibility of tumor-infiltrating lymphocyte (TIL) adoptive cell therapy (ACT) combined with dendritic cell (DC) vaccination in MM patients progressing on ICI. An initial cohort (5 patients) received TIL therapy alone to evaluate safety and allow for optimization of TIL expansion protocols. A second cohort (first-in-man, 5 patients) received TIL combined with autologous tumor lysate-loaded DC vaccination. All patients received cyclophosphamide/fludarabine preconditioning prior to, and intravenous (i.v.) IL-2 after, TIL transfer. The DC vaccine was given as five intradermal injections after TIL and IL-2 administration. [F-18]-FDG PET/CT radiology was performed to evaluate clinical response, according to RECIST 1.1 (on the CT part). Immunological monitoring was performed by flow cytometry and T-cell receptor (TCR) sequencing. In the safety/optimization cohort, all patients had a mixed response or stable disease, but none durable. In the combination cohort, two patients experienced complete responses (CR) that are still ongoing (>36 and >18 months, respectively). In addition, two patients had partial responses (PR), one still ongoing (>42 months) with only a small bone-lesion remaining, and one of short duration (<4 months). One patient died early during treatment and did not receive DC. Long-lasting persistency of the injected TILs was demonstrated in blood. In summary, we report clinical responses by TIL therapy combined with DC vaccination in 4 out of 4 treated MM patients who previously failed ICI.
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| 9. |
- nylander, stina, et al.
(författare)
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Runright : real-time visual and audio feedback on running
- 2014
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Ingår i: CHI EA '14 CHI '14 Extended Abstracts on Human Factors in Computing Systems. - New York : ACM Press. - 9781450324748 ; , s. 583-586
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Konferensbidrag (refereegranskat)abstract
- RunRight is a system that gives two different kinds of feedback for runners. First, it creates a visualization of the running movement based on acceleration in vertical and horizontal direction. Second it gives audio feedback on the rhythm. These two types of feedback are valuable when exploring how to design technology that supports athletes in learning how a desired movement should feel.
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| 10. |
- Torinsson Naluai, Åsa, 1968, et al.
(författare)
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Transcriptomics unravels molecular changes associated with cilia and COVID-19 in chronic rhinosinusitis with nasal polyps
- 2023
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Ingår i: Scientific Reports. - : Springer Nature. - 2045-2322. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common upper respiratory tract complication where the pathogenesis is largely unknown. Herein, we investigated the transcriptome profile in nasal mucosa biopsies of CRSwNP patients and healthy individuals. We further integrated the transcriptomics data with genes located in chromosomal regions containing genome-wide significant gene variants for COVID-19. Among the most significantly upregulated genes in polyp mucosa were CCL18, CLEC4G, CCL13 and SLC9A3. Pathways involving "Ciliated epithelial cells" were the most differentially expressed molecular pathways when polyp mucosa and non-polyp mucosa from the same patient was compared. Natural killer T-cell (NKT) and viral pathways were the most statistically significant pathways in the mucosa of CRSwNP patients compared with those of healthy control individuals. Upregulated genes in polyp mucosa, located within the genome-wide associated regions of COVID-19, included LZTFL1, CCR9, SLC6A20, IFNAR1, IFNAR2 and IL10RB. Interestingly, the second most over-expressed gene in our study, CLEC4G, has been shown to bind directly to SARS-CoV-2 spike's N-terminal domain and mediate its entry and infection. Our results on altered expression of genes related to cilia and viruses point to the de-regulation of viral defenses in CRSwNP patients, and may give clues to future intervention strategies.
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