| 1. |
- Cuttano, Roberto, et al.
(författare)
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KLF4 is a key determinant in the development and progression of cerebral cavernous malformations
- 2016
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Ingår i: EMBO Molecular Medicine. - : EMBO. - 1757-4676 .- 1757-4684. ; 8:1, s. 6-24
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Tidskriftsartikel (refereegranskat)abstract
- Cerebral cavernous malformations (CCMs) are vascular malformations located within the central nervous system often resulting in cerebral hemorrhage. Pharmacological treatment is needed, since current therapy is limited to neurosurgery. Familial CCM is caused by loss-of-function mutations in any of Ccm1, Ccm2, and Ccm3 genes. CCM cavernomas are lined by endothelial cells (ECs) undergoing endothelial-to-mesenchymal transition (EndMT). This switch in phenotype is due to the activation of the transforming growth factor beta/bone morphogenetic protein (TGFb/BMP) signaling. However, the mechanism linking Ccm gene inactivation and TGFb/ BMP-dependent EndMT remains undefined. Here, we report that Ccm1 ablation leads to the activation of a MEKK3-MEK5-ERK5MEF2 signaling axis that induces a strong increase in Kruppel-like factor 4 (KLF4) in ECs in vivo. KLF4 transcriptional activity is responsible for the EndMT occurring in CCM1-null ECs. KLF4 promotes TGFb/BMP signaling through the production of BMP6. Importantly, in endothelial-specific Ccm1 and Klf4 double knockout mice, we observe a strong reduction in the development of CCM and mouse mortality. Our data unveil KLF4 as a therapeutic target for CCM.
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| 2. |
- Mukesh Kumar, Awasthi, et al.
(författare)
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Techno-economics and life-cycle assessment of biological and thermochemical treatment of bio-waste
- 2021
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Ingår i: Renewable & sustainable energy reviews. - : Elsevier BV. - 1364-0321 .- 1879-0690. ; 144
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Tidskriftsartikel (refereegranskat)abstract
- The energy sector contributed to three-fourth of overall global emissions in the past decade. Biological wastes can be converted to useful energy and other byproducts via biological or thermo-chemical routes. However, issues such as techno-economic feasibility and lack of understanding on the overall lifecycle of a product have hindered commercialization. It is needed to recognize these inter-disciplinary factors. This review attempts to critically evaluate the role of technology, economics and lifecycle assessment of bio-waste in two processing types. This includes: 1. biological and, 2. thermo-chemical route. The key findings of this work are: 1. Policy support is essential for commercialization of a waste treatment technology; 2. adequate emphasis is necessary on the social dimensions in creating awareness; and 3. from a product development perspective, research should focus on industrial needs. The choice of the treatment and their commercialization depends on the regional demand of a product, policy support, and technology maturity. Utilization of bio-wastes to produce value-added products will enhance circular economy, which in turn improves sustainability.
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| 3. |
- Mukesh Kumar, Awasthi, et al.
(författare)
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Refining biomass residues for sustainable energy and bio-products : An assessment of technology, its importance, and strategic applications in circular bio-economy
- 2020
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Ingår i: Renewable & sustainable energy reviews. - : Elsevier Ltd. - 1364-0321 .- 1879-0690. ; 127
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Tidskriftsartikel (refereegranskat)abstract
- In the circular bio-economy, effective biomass valorization through the strategic use of resources is essential in terms of generating valuable products, sustainable development, and maximizing ecological and socio-economic benefits. Technologies are being developed and improved to optimize the use of abundant biomass and to generate several value-added products. Efficient nutrient recovery requires additional energy-intensive steps for effective valorization. Moreover, appropriate waste collection and pretreatment practices increase the degree of valorization. The use of biomass waste in biorefineries has significant potential to yield biofuels and organic fertilizers. Further research and development are required to develop effective biorefining technologies to enable the efficient exploitation of bioresources. Greater consideration should be applied to energy pathways to support this technology. Therefore, there is a demand for innovation in the integrated biorefining approach in response to changing markets, and novel commercial models should be introduced into the circular economy.
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