SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Jaks V) "

Sökning: WFRF:(Jaks V)

  • Resultat 1-10 av 33
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  •  
3.
  •  
4.
  •  
5.
  • Jaks, V, et al. (författare)
  • The hair follicle-a stem cell zoo
  • 2010
  • Ingår i: Experimental cell research. - : Elsevier BV. - 1090-2422 .- 0014-4827. ; 316:8, s. 1422-1428
  • Tidskriftsartikel (refereegranskat)
  •  
6.
  •  
7.
  •  
8.
  • Kasper, M, et al. (författare)
  • Hedgehog signalling in breast cancer
  • 2009
  • Ingår i: Carcinogenesis. - : Oxford University Press (OUP). - 1460-2180 .- 0143-3334. ; 30:6, s. 903-911
  • Tidskriftsartikel (refereegranskat)
  •  
9.
  •  
10.
  • Kasper, M, et al. (författare)
  • Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes
  • 2011
  • Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 108:10, s. 4099-4104
  • Tidskriftsartikel (refereegranskat)abstract
    • Chronic wounds and acute trauma constitute well-established risk factors for development of epithelial-derived skin tumors, although the underlying mechanisms are largely unknown. Basal cell carcinomas (BCCs) are the most common skin cancers displaying a number of features reminiscent of hair follicle (HF)-derived cells and are dependent on deregulated Hedgehog (Hh)/GLI signaling. Here we show, in a mouse model conditionally expressing GLI1 and in a model with homozygous inactivation of Ptch1, mimicking the situation in human BCCs, that the wound environment accelerates the initiation frequency and growth of BCC-like lesions. Lineage tracing reveals that both oncogene activation and wounding induce emigration of keratinocytes residing in the lower bulge and the nonpermanent part of the HFs toward the interfollicular epidermis (IFE). However, only oncogene activation in combination with a wound environment enables the participation of such cells in the initiation of BCC-like lesions at the HF openings and in the IFE. We conclude that, in addition to the direct enhancement of BCC growth, the tumor-promoting effect of the wound environment is due to recruitment of tumor-initiating cells originating from the neighboring HFs, establishing a link between epidermal wounds and skin cancer risk.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 33

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy