| 1. |
- Jalloh, Mohamed F., et al.
(författare)
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Evidence of behaviour change during an Ebola virus disease outbreak, Sierra Leone
- 2020
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Ingår i: Bulletin of the World Health Organization. - : World Health Organization. - 0042-9686 .- 1564-0604. ; 98:5, s. 330-340
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Tidskriftsartikel (refereegranskat)abstract
- Objective To evaluate changes in Ebola-related knowledge, attitudes and prevention practices during the Sierra Leone outbreak between 2014 and 2015.Methods Four cluster surveys were conducted: two before the outbreak peak (3499 participants) and two after (7104 participants). We assessed the effect of temporal and geographical factors on 16 knowledge, attitude and practice outcomes.Findings Fourteen of 16 knowledge, attitude and prevention practice outcomes improved across all regions from before to after the outbreak peak. The proportion of respondents willing to: (i) welcome Ebola survivors back into the community increased from 60.0% to 89.4% (adjusted odds ratio, aOR: 6.0; 95% confidence interval, CI: 3.9–9.1); and (ii) wait for a burial team following a relative’s death increased from 86.0% to 95.9% (aOR: 4.4; 95% CI: 3.2–6.0). The proportion avoiding unsafe traditional burials increased from 27.3% to 48.2% (aOR: 3.1; 95% CI: 2.4–4.2) and the proportion believing spiritual healers can treat Ebola decreased from 15.9% to 5.0% (aOR: 0.2; 95% CI: 0.1–0.3). The likelihood respondents would wait for burial teams increased more in high-transmission (aOR: 6.2; 95% CI: 4.2–9.1) than low-transmission (aOR: 2.3; 95% CI: 1.4–3.8) regions. Self-reported avoidance of physical contact with corpses increased in high but not low-transmission regions, aOR: 1.9 (95% CI: 1.4–2.5) and aOR: 0.8 (95% CI: 0.6–1.2), respectively.Conclusion Ebola knowledge, attitudes and prevention practices improved during the Sierra Leone outbreak, especially in high-transmission regions. Behaviourally-targeted community engagement should be prioritized early during outbreaks.
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| 2. |
- Lyons, Padraig, et al.
(författare)
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Quantifying the Impact of Engaging Religious Leaders to Promote Safe Burial Practices During the 2014-2016 Ebola Outbreak in Sierra Leone
- 2024
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Ingår i: SSRN Electronic Journal. - : Elsevier BV. - 1556-5068.
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Background: Traditional burials involving physical contact with deceased Ebola Virus Disease (Ebola) victims were linked to disease transmission during the 2014-2016 Ebola outbreak in West Africa. An estimated 2 · 5 new cases of Ebola resulted from each traditional burial. Over 6,000 religious leaders across Sierra Leone were engaged to promote the use of specialised burial teams in order to avoid risky traditional practices. We aimed to quantify the impact of engaging religious leaders in promoting safe burials during the outbreak in Sierra Leone. Methods: We analysed population-based household survey data (N=3,540) collected around the peak of the outbreak in Sierra Leone in December 2014. Multilevel logistic regression modelling was used to examine if exposure to faith-based messages was associated with protective burial intentions and behaviours. Findings: Exposure to faith-based messages was associated with a nearly two-fold increase in the intention to accept safe alternatives to traditional burials and the intention to await burial teams for ≥2 days (adjusted odds ratio [aOR] 1·69, 95% confidence interval [CI] 1·23-2·31 and aOR 1·84; 95% CI 1·38-2·44 respectively). Behaviourally, exposure to faith-based messages was also associated with an increased reported avoidance of traditional burials and an increased reported avoidance of suspected Ebola patients (aOR 1·46, 95%CI 1·14-1·89, aOR 1·65 95% CI, CI 1·27-2·13 respectively).Interpretation: Faith-based messages promoted by religious leaders may have influenced safe burial intentions and protective behaviours during the Ebola outbreak in Sierra Leone. Engagement of religious leaders in risk communication should be prioritised during health emergencies in similar settings.
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| 3. |
- Winters, Maike, et al.
(författare)
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Debunking highly prevalent health misinformation using audio dramas delivered by WhatsApp : evidence from a randomised controlled trial in Sierra Leone
- 2021
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Ingår i: BMJ Global Health. - : BMJ Publishing Group Ltd. - 2059-7908. ; 6:11
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Tidskriftsartikel (refereegranskat)abstract
- Introduction Infectious disease misinformation is widespread and poses challenges to disease control. There is limited evidence on how to effectively counter health misinformation in a community setting, particularly in low-income regions, and unsettled scientific debate about whether misinformation should be directly discussed and debunked, or implicitly countered by providing scientifically correct information.Methods The Contagious Misinformation Trial developed and tested interventions designed to counter highly prevalent infectious disease misinformation in Sierra Leone, namely the beliefs that (1) mosquitoes cause typhoid and (2) typhoid co-occurs with malaria. The information intervention for group A (n=246) explicitly discussed misinformation and explained why it was incorrect and then provided the scientifically correct information. The intervention for group B (n=245) only focused on providing correct information, without directly discussing related misinformation. Both interventions were delivered via audio dramas on WhatsApp that incorporated local cultural understandings of typhoid. Participants were randomised 1:1:1 to the intervention groups or the control group (n=245), who received two episodes about breast feeding.Results At baseline 51% believed that typhoid is caused by mosquitoes and 59% believed that typhoid and malaria always co-occur. The endline survey was completed by 91% of participants. Results from the intention-to-treat, per-protocol and as-treated analyses show that both interventions substantially reduced belief in misinformation compared with the control group. Estimates from these analyses, as well as an exploratory dose–response analysis, suggest that direct debunking may be more effective at countering misinformation. Both interventions improved people’s knowledge and self-reported behaviour around typhoid risk reduction, and yielded self-reported increases in an important preventive method, drinking treated water.Conclusion These results from a field experiment in a community setting show that highly prevalent health misinformation can be countered, and that direct, detailed debunking may be most effective.Trial registration number NCT04112680.
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| 4. |
- Winters, Maike, et al.
(författare)
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Risk communication and Ebola-Specific knowledge and behavior during 2014-2015 outbreak, Sierra Leone
- 2018
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Ingår i: Emerging Infectious Diseases. - : Centers for Disease Control and Prevention (CDC). - 1080-6040 .- 1080-6059. ; 24:2, s. 336-344
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Tidskriftsartikel (refereegranskat)abstract
- We assessed the effect of information sources on Ebola-specific knowledge and behavior during the 2014-2015 Ebola virus disease outbreak in Sierra Leone. We pooled data from 4 population-based knowledge, attitude, and practice surveys (August, October, and December 2014 and July 2015), with a total of 10,604 respondents. We created composite variables for exposures (information sources: electronic, print, new media, government, community) and outcomes (knowledge and misconceptions, protective and risk behavior) and tested associations by using logistic regression within multilevel modeling. Exposure to information sources was associated with higher knowledge and protective behaviors. However, apart from print media, exposure to information sources was also linked to misconceptions and risk behavior, but with weaker associations observed. Knowledge and protective behavior were associated with the outbreak level, most strongly after the peak, whereas risk behavior was seen at all levels of the outbreak. In future outbreaks, close attention should be paid to dissemination of information.
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| 5. |
- Hoffmann, Thomas J, et al.
(författare)
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Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves cross-ancestry prediction
- 2023
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- We conducted a multi-ancestry genome-wide association study of prostate-specific antigen (PSA) levels in 296,754 men (211,342 European ancestry; 58,236 African ancestry; 23,546 Hispanic/Latino; 3,630 Asian ancestry; 96.5% of participants were from the Million Veteran Program). We identified 318 independent genome-wide significant (p≤5e-8) variants, 184 of which were novel. Most demonstrated evidence of replication in an independent cohort (n=95,768). Meta-analyzing discovery and replication (n=392,522) identified 447 variants, of which a further 111 were novel. Out-of-sample variance in PSA explained by our new polygenic risk score reached 16.9% (95% CI=16.1%-17.8%) in European ancestry, 9.5% (95% CI=7.0%-12.2%) in African ancestry, 18.6% (95% CI=15.8%-21.4%) in Hispanic/Latino, and 15.3% (95% CI=12.7%-18.1%) in Asian ancestry, and lower for higher age. Our study highlights how including proportionally more participants from underrepresented populations improves genetic prediction of PSA levels, with potential to personalize prostate cancer screening.
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| 6. |
- Jalloh, Mohamed F., et al.
(författare)
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Barriers and facilitators to reporting deaths following Ebola surveillance in Sierra Leone : implications for sustainable mortality surveillance based on an exploratory qualitative assessment
- 2021
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Ingår i: BMJ Open. - : BMJ. - 2044-6055. ; 11:5
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: To understand the barriers contributing to the more than threefold decline in the number of deaths (of all causes) reported to a national toll free telephone line (1-1-7) after the 2014-2016 Ebola outbreak ended in Sierra Leone and explore opportunities for improving routine death reporting as part of a nationwide mortality surveillance system. DESIGN: An exploratory qualitative assessment comprising 32 in-depth interviews (16 in Kenema district and 16 in Western Area). All interviews were audio-recorded, transcribed and analysed using qualitative content analysis to identify themes. SETTING: Participants were selected from urban and rural communities in two districts that experienced varying levels of Ebola cases during the outbreak. All interviews were conducted in August 2017 in the post-Ebola-outbreak context in Sierra Leone when the Sierra Leone Ministry of Health and Sanitation was continuing to mandate reporting of all deaths. PARTICIPANTS: Family members of deceased persons whose deaths were not reported to the 1-1-7 system. RESULTS: Death reporting barriers were driven by the lack of awareness to report all deaths, lack of services linked to reporting, negative experiences from the Ebola outbreak including prohibition of traditional burial rituals, perception that inevitable deaths do not need to be reported and situations where prompt burials may be needed. Facilitators of future willingness to report deaths were largely influenced by the perceived communicability and severity of the disease, unexplained circumstances of the death that need investigation and the potential to leverage existing death notification practices through local leaders. CONCLUSIONS: Social mobilisation and risk communication efforts are needed to help the public understand the importance and benefits of sustained and ongoing death reporting after an Ebola outbreak. Localised practices for informal death notification through community leaders could be integrated into the formal reporting system to capture community-based deaths that may otherwise be missed.
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| 7. |
- Jalloh, Mohamed Falilu
(författare)
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Behavioral surveillance during and after the 2014–2016 Ebola outbreak in Sierra Leone
- 2020
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Background: The first documented case of Ebola Virus Disease (Ebola) in Sierra Leone was confirmed in May 2014 in Kailahun district after cases had been reported in Guinea and Liberia. Ebola is transmitted through contact with infected blood, stool, and other bodily fluids. Transmission risk in West Africa was driven by traditional burials involving physical contact with corpses, caring for infected persons without adequate protection, and delaying medical care. Sexual transmission due to viral persistence in the semen of male survivors posed an additional risk. Experimental Ebola vaccine candidates were implemented to curb transmission among health workers and other high–risk individuals. Reporting of all deaths to a national toll–free line (1–1–7 system) was mandated so that burials could be handled by teams trained in infection prevention and control. Aim: To understand trends in population–level Ebola knowledge, attitudes and prevention practices throughout different stages of the outbreak, acceptability of experimental Ebola vaccines at the peak of the outbreak and reporting of deaths after the outbreak ended. Methods: Four cross–sectional household surveys (N=10,603) were conducted using multi– stage cluster sampling in August 2014, October 2014, December 2014, and July 2015 to measure trends in Ebola–related knowledge, attitudes, and prevention practices (KAP). In– depth interviews (N=31) and focus group discussions (N=35) were conducted with health workers, frontline workers, and community members between December 2014 and January 2014 to understand acceptability of Ebola vaccine. Population–level demand for Ebola vaccine was assessed in a national household survey in December 2014 (N=3,540). After the outbreak ended, in 2017, motivations and barriers related to death reporting were assessed through a national telephone survey (N=1,291) and in–depth interviews (N=32). Quantitative data were analyzed using multilevel and ordered logistic regression modeling to examine various associations. Content analysis was used to identify cross–cutting themes in the qualitative data. Results: Ebola–related knowledge, attitudes, and prevention practices improved throughout the outbreak, especially in high–transmission regions. For example, when comparing before and after the peak of the outbreak, avoidance of physical contact with suspected Ebola patients nearly doubled in high–transmission areas (adjusted odds ratio (aOR) 1.9 [95% confidence interval 1.4–2.5]). Acceptability of Ebola vaccine was discouraged by safety related concerns but encouraged by altruistic motivation to help end the outbreak. Nationally, 74% of the public expressed high demand for Ebola vaccine, which was associated with wanting to be the first to get the vaccine compared to wanting politicians to be the first to get the vaccine (aOR 13.0; [7.8–21.6]). The number of deaths reported to the 1–1–7 system nationally in 2017 after the outbreak had ended represented nearly 12% of the expected deaths in the country versus almost 34% in 2016 and as much as 100% in 2015; albeit not accounting for potential duplicate reporting. After the Ebola outbreak, motivation to report deaths was greater if the decedent experienced one or more Ebola–like symptoms compared to none (aOR 2.3 [1.8–2.9]. Barriers to reporting deaths after the outbreak were driven by the lack of awareness to report all deaths, lack of reciprocal benefits linked to reporting, and negative experiences from the outbreak. Conclusions: Ebola prevention practices improved nationally during the outbreak in Sierra Leone, but the magnitude of improvement was greater in high–transmission regions compared to low–transmission regions. Understanding the drivers of Ebola vaccine acceptability and demand was important to inform ethical and cultural considerations in the implementation of experimental Ebola vaccines. While the 1–1–7 system was ramped up to capture nearly all deaths during the outbreak, reporting substantially declined after the outbreak ended. Failure to report deaths after the outbreak was due to lack of awareness to report all deaths and lack of perceived benefits to report in the post–Ebola–outbreak setting. Nevertheless, knowledge and experiences from the Ebola outbreak increasingly motivated people to report deaths that exhibited Ebola–like symptoms. Post–Ebola–outbreak settings offer an opportunity to implement routine mortality surveillance, however, substantial social mobilization efforts may be required to optimize reporting.
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| 8. |
- Jalloh, Mohamed F., et al.
(författare)
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Drivers of COVID-19 policy stringency in 175 countries and territories : COVID-19 cases and deaths, gross domestic products per capita, and health expenditures
- 2022
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Objective: To understand the associations of COVID-19 cases and deaths with policy stringency globally and regionally.Methods: We modeled the marginal effects of new COVID-19 cases and deaths on policy stringency (scored 0–100) in 175 countries and territories, adjusting for gross domestic product (GDP) per capita and health expenditure (% of GDP). Time periods examined were March–August 2020, September 2020– February 2021, and March–August 2021.Results: Policy response to new cases and deaths was faster and more stringent early in the COVID-19 pandemic (March–August 2020) compared to subsequent periods. New deaths were more strongly associated with stringent policies than new cases. In an average week, 1 new death per 100,000 people was associated with a stringency increase of 2.1 units in March–August 2020, 1.3 units in September 2020–February 2021, and 0.7 units in March–August 2021. New deaths in Africa and the Western Pacific were associated with more stringency than in other regions. Higher health expenditure was associated with less stringent policies. GDP per capita did not have consistent patterns of associations with stringency.Conclusions: Our findings demonstrate the need for enhanced mortality surveillance to ensure policy alignment during health emergencies. Countries that invest less of their GDP in health are inclined to enact stringent policies during health emergencies than countries with more significant health expenditure.
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| 9. |
- Jalloh, Mohamed F., et al.
(författare)
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Drivers of COVID-19 policy stringency in 175 countries and territories : COVID-19 cases and deaths, gross domestic products per capita, and health expenditures
- 2022
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Ingår i: Journal of Global Health. - : International Society of Global Health (ISoGH). - 2047-2978 .- 2047-2986. ; 12
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Background: New data on COVID-19 may influence the stringency of containment policies, but these potential effect are not understood. We aimed to understand the associations of new COVID-19 cases and deaths with policy stringency globally and regionally.Methods: We modelled the marginal effects of new COVID-19 cases and deaths on policy stringency (scored 0-100) in 175 countries and territories, adjusting for gross domestic product (GDP) per capita and health expenditure (% of GDP), and public expenditure on health. The time periods examined were March to August 2020, September 2020 to February 2021, and March to August 2021.Results: Policy response to new cases and deaths was faster and more stringent early in the COVID-19 pandemic (March to August 2020) compared to subsequent periods. New deaths were more strongly associated with stringent policies than new cases. In an average week, one new death per 100 000 people was associated with a stringency increase of 2.1 units in the March to August 2020 period, 1.3 units in the September 2020 to February 2021 period, and 0.7 units in the March to August 2021 period. New deaths in Africa and the Western Pacific were associated with more stringency than in other regions. Higher health expenditure as a percentage of GDP was associated with less stringent policies. Similarly, higher public expenditure on health by governments was mostly associated with less stringency across all three periods. GDP per capita did not have consistent patterns of associations with stringency.Conclusions: The stringency of COVID-19 policies was more strongly associated with new deaths than new cases. Our findings demonstrate the need for enhanced mortality surveillance to ensure policy alignment during health emergencies. Countries that invest less in health or have a lower public expenditure on health may be inclined to enact more stringent policies. This new empirical understanding of COVID-19 policy drivers can help public health officials anticipate and shape policy responses in future health emergencies.
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| 10. |
- Jalloh, Mohamed F., et al.
(författare)
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Ebola vaccine? Family first! Evidence from using a brief measure on Ebola vaccine demand in a national household survey during the outbreak in Sierra Leone
- 2020
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Ingår i: Vaccine. - : Elsevier. - 0264-410X .- 1873-2518. ; 38:22, s. 3854-3861
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Tidskriftsartikel (refereegranskat)abstract
- Background: Vaccination against Ebolavirus is an emerging public health tool during Ebola Virus Disease outbreaks. We examined demand issues related to deployment of Ebolavirus vaccine during the 2014–2015 outbreak in Sierra Leone. Methods: A cluster survey was administered to a population-based sample in December 2014 (N = 3540), before any Ebola vaccine was available to the general public in Sierra Leone. Ebola vaccine demand was captured in this survey by three Likert-scale items that were used to develop a composite score and dichotomized into a binary outcome to define high demand. A multilevel logistic regression model was fitted to assess the associations between perceptions of who should be first to receive an Ebola vaccine and the expression of high demand for an Ebola vaccine. Results: The largest proportion of respondents reported that health workers (35.1%) or their own families (29.5%) should receive the vaccine first if it became available, rather than politicians (13.8%), vaccination teams (9.8%), or people in high risk areas (8.2%). High demand for an Ebola vaccine was expressed by 74.2% of respondents nationally. The odds of expressing high demand were 13 times greater among those who said they or their families should be the first to take the vaccine compared to those who said politicians should be the first recipients (adjusted odds ratio [aOR] 13.0 [95% confidence interval [CI] 7.8–21.6]). The ultra-brief measure of the Ebola vaccine demand demonstrated acceptable scale reliability (Cronbach's α = 0.79) and construct validity (single-factor loadings > 0.50). Conclusion: Perceptions of who should be the first to get the vaccine was associated with high demand for Ebola vaccine around the peak of the outbreak in Sierra Leone. Using an ultra-brief measure of Ebola vaccine demand is a feasible solution in outbreak settings and can help inform development of future rapid assessment tools.
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