| 1. |
- Filipowicz, Natalia, et al.
(författare)
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Comprehensive cancer-oriented biobanking resource of human samples for studies of post-zygotic genetic variation involved in cancer predisposition
- 2022
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 17:4
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Tidskriftsartikel (refereegranskat)abstract
- The progress in translational cancer research relies on access to well-characterized samples from a representative number of patients and controls. The rationale behind our biobanking are explorations of post-zygotic pathogenic gene variants, especially in non-tumoral tissue, which might predispose to cancers. The targeted diagnoses are carcinomas of the breast (via mastectomy or breast conserving surgery), colon and rectum, prostate, and urinary bladder (via cystectomy or transurethral resection), exocrine pancreatic carcinoma as well as metastases of colorectal cancer to the liver. The choice was based on the high incidence of these cancers and/or frequent fatal outcome. We also collect age-matched normal controls. Our still ongoing collection originates from five clinical centers and after nearly 2-year cooperation reached 1711 patients and controls, yielding a total of 23226 independent samples, with an average of 74 donors and 1010 samples collected per month. The predominant diagnosis is breast carcinoma, with 933 donors, followed by colorectal carcinoma (383 donors), prostate carcinoma (221 donors), bladder carcinoma (81 donors), exocrine pancreatic carcinoma (15 donors) and metachronous colorectal cancer metastases to liver (14 donors). Forty percent of the total sample count originates from macroscopically healthy cancer-neighboring tissue, while contribution from tumors is 12%, which adds to the uniqueness of our collection for cancer predisposition studies. Moreover, we developed two program packages, enabling registration of patients, clinical data and samples at the participating hospitals as well as the central system of sample/data management at coordinating center. The approach used by us may serve as a model for dispersed biobanking from multiple satellite hospitals. Our biobanking resource ought to stimulate research into genetic mechanisms underlying the development of common cancers. It will allow all available "-omics" approaches on DNA-, RNA-, protein- and tissue levels to be applied. The collected samples can be made available to other research groups.
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| 2. |
- Małyszko, Jolanta, et al.
(författare)
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Do we know more about hypertension in Poland after the May Measurement Month 2017? - Europe
- 2019
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Ingår i: European Heart Journal, Supplement. - : Oxford University Press (OUP). - 1520-765X .- 1554-2815. ; 21, s. 97-100
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Forskningsöversikt (refereegranskat)abstract
- Elevated blood pressure (BP) is a worldwide burden, leading to over 10 million deaths yearly. May Measurement Month (MMM) is a global initiative organized by the International Society of Hypertension aimed at raising awareness of hypertension and the need for BP screening. An opportunistic cross-sectional survey of volunteers aged ≥18 was carried out in May 2017. BP measurement, the definition of hypertension and statistical analysis followed the globally approved MMM17 Study Protocol. In Poland 5834 (98.9%, Caucasian) individuals were screened. After multiple imputation, 2601 (35.3%) had hypertension. Of individuals not receiving anti-hypertensive medication, 976 (20.6%) were hypertensive. Of individuals receiving anti-hypertensive medication, 532 (49.1%) had uncontrolled BP. In the crude screened group, 81.4% declared to not receive any anti-hypertensive treatment, while the remaining 18.6% were on such medications. In overweight and obese patients both systolic and diastolic BP were significantly higher than in normal weight and underweight subjects. In addition, BP measured on Sundays was significantly lower than on Mondays. MMM17 was one of the largest recent BP screening campaigns in Poland. We found that over 1/3 of participants were hypertensive. Almost half of the treated subjects had uncontrolled BP. These results suggest that opportunistic screening can identify substantial numbers with raised BP.
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| 3. |
- Forestier, C., et al.
(författare)
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Comparative investigation of solid electrolyte interphases created by the electrolyte additives vinyl ethylene carbonate and dicyano ketene vinyl ethylene acetal
- 2017
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Ingår i: Journal of Power Sources. - : Elsevier BV. - 0378-7753. ; 345, s. 212-220
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Tidskriftsartikel (refereegranskat)abstract
- The effect of the replacement of the carbonyl oxygen in VEC additive by =C(CN)(2) in the analogous dicyano ketene vinyl ethylene acetal (DCKVEA) on the electrochemical reduction profile is significant. Yet, the additives were proven, through IR spectroscopy supported by DFT computations, by applying EELS techniques and performing synthesis of a reduction product, to reduce in a similar way. Interestingly, the reduction-induced capacities were found to be quite different and can be explained either by the different properties of the SEI, from lithium carbonate and its malononitrile homologue, or by the different abilities of the two additives to solvate Li+.
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| 4. |
- Forestier, C., et al.
(författare)
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Facile reduction of pseudo-carbonates: Promoting solid electrolyte interphases with dicyanoketene alkylene acetals in lithium-ion batteries
- 2016
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Ingår i: Journal of Power Sources. - : Elsevier BV. - 0378-7753. ; 303, s. 1-9
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Tidskriftsartikel (refereegranskat)abstract
- Dicyanoketene ethylene and propylene acetals, DCKEA and DCKPA respectively, have been investigated as electrolyte additives for Li-ion batteries. The purpose was to assess the changes in reduction behaviour and solid electrolyte interphase (SEI) passivation properties upon replacing the carbonyl group of ethylene carbonate (EC) and propylene carbonate (PC) solvents, respectively, by the slightly more electronegative and highly conjugated =C(CN)(2) group. The experimental reduction potentials and the IR spectroscopy characterisation efforts were further supported by density functional theory (DFT) computations. The two additives were found to, in relatively small amount (0.5 wt%), provide beneficial effects on the capacity retention of 8 mAh cells cycled at 20 and 45 degrees C. Moreover, the additives proved to enhance the thermal stability of the lithiated graphite/electrolyte interface, as deduced from DSC measurements.
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| 5. |
- Forsberg, Lars A., et al.
(författare)
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Signatures of post-zygotic structural genetic aberrations in the cells of histologically normal breast tissue that can predispose to sporadic breast cancer
- 2015
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Ingår i: Genome Research. - : Cold Spring Harbor Laboratory. - 1088-9051 .- 1549-5469. ; 25:10, s. 1521-1535
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Tidskriftsartikel (refereegranskat)abstract
- Sporadic breast cancer (SBC) is a common disease without robust means of early risk prediction in the population. We studied 282 females with SBC, focusing on copy number aberrations in cancer-free breast tissue (uninvolved margin, UM) outside the primary tumor (PT). In total, 1162 UMs (1-14 per breast) were studied. Comparative analysis between UM(s), PT(s), and blood/skin from the same patient as a control is the core of the study design. We identified 108 patients with at least one aberrant UM, representing 38.3% of cases. Gains in gene copy number were the principal type of mutations in microscopically normal breast cells, suggesting that oncogenic activation of genes via increased gene copy number is a predominant mechanism for initiation of SBC pathogenesis. The gain of ERBB2, with overexpression of HER2 protein, was the most common aberration in normal cells. Five additional growth factor receptor genes (EGFR, FGFR1, IGF1R, LIFR, and NGFR) also showed recurrent gains, and these were occasionally present in combination with the gain of ERBB2. All the aberrations found in the normal breast cells were previously described in cancer literature, suggesting their causative, driving role in pathogenesis of SBC. We demonstrate that analysis of normal cells from cancer patients leads to identification of signatures that may increase risk of SBC and our results could influence the choice of surgical intervention to remove all predisposing cells. Early detection of copy number gains suggesting a predisposition toward cancer development, long before detectable tumors are formed, is a key to the anticipated shift into a preventive paradigm of personalized medicine for breast cancer.
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| 6. |
- Franco, Alejandro A., et al.
(författare)
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Boosting Rechargeable Batteries R&D by Multiscale Modeling: Myth or Reality?
- 2019
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Ingår i: Chemical Reviews. - : American Chemical Society (ACS). - 0009-2665 .- 1520-6890. ; 119:7, s. 4569-4627
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Tidskriftsartikel (refereegranskat)abstract
- This review addresses concepts, approaches, tools, and outcomes of multiscale modeling used to design and optimize the current and next generation rechargeable battery cells. Different kinds of multiscale models are discussed and demystified with a particular emphasis on methodological aspects. The outcome is compared both to results of other modeling strategies as well as to the vast pool of experimental data available. Finally, the main challenges remaining and future developments are discussed.
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| 7. |
- Fretz, Samuel Joseph, 1987, et al.
(författare)
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Amine- and Amide-Functionalized Mesoporous Carbons: A Strategy for Improving Sulfur/Host Interactions in Li-S Batteries
- 2020
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Ingår i: Batteries and Supercaps. - : Wiley. - 2566-6223. ; 3:8, s. 757-765
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Tidskriftsartikel (refereegranskat)abstract
- Lithium-sulfur (Li-S) batteries are of great interest due to their potentially high energy density, but the low electronic conductivity of both the sulfur (S-8) cathode active material and the final discharge product lithium sulfide (Li2S) require the use of a conductive host. Usually made of relatively hydrophobic carbon, such hosts are typically ill-suited to retain polar discharge products such as the intermediate lithium polysulfides (LiPs) and the final Li2S. Herein, we propose a route to increase the sulfur utilization by functionalizing the surface of ordered mesoporous carbon CMK3 with polar groups. These derivatized CMK3 materials are made using a simple two-step procedure of bromomethylation and subsequent nucleophilic substitution with amine or amide nucleophiles. We demonstrate that, compared to the unfunctionalized control, these modified CMK3 surfaces have considerably larger binding energies with LiPs and Li2S, which are proposed to aid the electrochemical conversion between S-8 and Li2S by keeping the LiPs species in close proximity to the carbon surface during Li-S battery cycling. As a result, the functionalized cathodes exhibit significantly improved specific capacities relative to their unmodified precursor.
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| 8. |
- Grugeon, S., et al.
(författare)
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Towards a better understanding of vinylene carbonate derived SEI-layers by synthesis of reduction compounds
- 2019
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Ingår i: Journal of Power Sources. - : Elsevier BV. - 0378-7753. ; 427, s. 77-84
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Tidskriftsartikel (refereegranskat)abstract
- Here two chemical reduction pathways to synthesize the vinylene carbonate (VC)and poly(VC)reduction products are investigated, with the precise aim of further deciphering the lithium-ion battery solid electrolyte interphase (SEI)layer composition and the associated reduction mechanisms. The liquid synthesis pathway offers the opportunity of varying the concentration of Li-4,4′-Di-tert-butylbiphenyl reducing agent, whereas the dry synthesis pathway by ball milling allows to solve issues related to solvent-induced side reactions and washing procedure. As a result, the two syntheses do not unveil the same reduction mechanisms, favouring either carboxylate or carbonate salts as the major end product. The latter pathway is very efficient in terms of providing SEI-layers products resulting in well-defined IR spectra and comparisons with simulated spectra enable us to obtain IR fingerprints of the Li di-vinylene di-carbonate (LDVD)compound. Taken together the synthesis procedures provide information on conditions favouring radical polymerization and further poly(VC)reduction into Li 2 CO 3 and polyacetylene. Overall, this chemical simulation of SEI-layers formation assists in a proper characterization of the SEI-layers created on graphite surfaces by their IR spectra showing that Li 2 CO 3 , LDVD and poly(VC)are all present in different proportions dependent on the VC content in the electrolyte.
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| 9. |
- Jankowski, Piotr, 1990, et al.
(författare)
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Anion amphiprotic ionic liquids as protic electrolyte matrices allowing sodium metal plating
- 2019
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Ingår i: Chemical Communications. - : Royal Society of Chemistry (RSC). - 1364-548X .- 1359-7345. ; 55:83, s. 12523-12526
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Tidskriftsartikel (refereegranskat)abstract
- The sodium-ion battery (SIB) is proposed as a complementary technology to today's commercially dominant lithium-ion battery (LIB). While much know-how can be transferred from LIBs to SIBs, adjustments are still necessary, not the least for the electrolytes employed. Here the use of anion amphiprotic ionic liquid (AAIL) based electrolytes is proposed for SIB application. Two different AAILs, based on organic trifluoromethylsulfonylamide (TFSAm) and inorganic HSO4- anions, respectively, doped with NaTFSI salt have been studied, focusing on electrochemical stability and transport properties, complemented by studies of the ion-ion interactions, and final sodium-ion battery performance via stripping/plating vs. sodium metal electrodes.
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| 10. |
- Jankowski, Piotr, 1990, et al.
(författare)
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Chemically soft solid electrolyte interphase forming additives for lithium-ion batteries
- 2018
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Ingår i: Journal of Materials Chemistry A. - : Royal Society of Chemistry (RSC). - 2050-7488 .- 2050-7496. ; 6:45, s. 22609-22618
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Tidskriftsartikel (refereegranskat)abstract
- The solid electrolyte interphase (SEI) layer is a key element of lithium-ion batteries (LIBs) enabling stable operation and significantly affecting the cycling performance including life-length. Here we present the concept of chemically soft SEI-forming additives, created by introducing aromatic ring based derivatives of already well-known SEI-formers to render them chemically soft, resulting in 1,3,2-benzodioxathiole 2,2-dioxide (DTDPh), 3H-1,2-benzoxathiole 2,2-dioxide (PSPh), and 1,4,2-benzodioxathiine 2,2-dioxide (PSOPh). A computational DFT based comparison predicts promise with respect to both early and controlled reduction processes. These predictions are verified by basic electrochemical studies targeting appropriate additive reduction potentials i.e. prior to any electrolyte solvent or salt decomposition. In addition, the decomposition paths of the SEI-formers are projected and the end products compared with spectroscopic data for the SEI-layers formed in LIB cells. The SEI-layers formed finally show very good properties in terms of improved capacity retention, improved coulombic efficiency, and reduced resistance for the graphite/electrolyte/LFP full cells made, especially observed for PSOPh. That is due to the preferred C-O bond breaking mechanism, observed also for DTDPh, and supported by the S-C bond breaking mechanism, together resulting in well conductive and good adhesion properties of the SEI-layers. This is expedited by higher softness, eventuating in a formation process stabilizing some of the radicals and/or lowering the kinetic barriers. These positive effects are confirmed both when applying a commercial style electrolyte and for a new generation electrolyte based on the LiTDI salt, where suppression of the TDI anion reduction is truly crucial.
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