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- Janssens, Lise, et al.
(författare)
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Transformative learning in business economics education : The development of a measurement instrument to detect student perspectives
- 2024
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Ingår i: The International Journal of Management Education. - : Elsevier. - 1472-8117 .- 2352-3565. ; 22:2
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Tidskriftsartikel (refereegranskat)abstract
- Previous studies of business economics education have highlighted differences regarding the role of businesses towards sustainability, as articulated by teachers, students and in textbooks. The roles differ from externally motivated (following law and customers) to internally driven (creating new routes) to address sustainability in the business context. Changes by students in their perspectives on the role of a business in relation to sustainability can be seen as examples of a transformative learning experience in the context of business economics education. This paper presents a measurement instrument of 12 items on a five-point Likert scale to measure the views of students regarding the role of a responsible businessperson. A mixed-methods approach was used to develop, test and validate the instrument. Data were gathered by business economics students at Hasselt University. The added value of the instrument is that it can be used in educational practice and in further research to indicate whether transformative learning is happening in the context of business education and to gain insight into students' views on the role of a responsible businessperson. The instrument goes beyond existing attitude, knowledge and competence scales and contributes to assessing transformative learning for sustainable development.
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| 2. |
- Palmer, Elizabeth E., et al.
(författare)
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Functional and clinical studies reveal pathophysiological complexity of CLCN4-related neurodevelopmental condition
- 2023
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Ingår i: Molecular Psychiatry. - : SPRINGERNATURE. - 1359-4184 .- 1476-5578. ; 28:2, s. 668-697
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Tidskriftsartikel (refereegranskat)abstract
- Missense and truncating variants in the X-chromosome-linked CLCN4 gene, resulting in reduced or complete loss-of-function (LOF) of the encoded chloride/proton exchanger ClC-4, were recently demonstrated to cause a neurocognitive phenotype in both males and females. Through international clinical matchmaking and interrogation of public variant databases we assembled a database of 90 rare CLCN4 missense variants in 90 families: 41 unique and 18 recurrent variants in 49 families. For 43 families, including 22 males and 33 females, we collated detailed clinical and segregation data. To confirm causality of variants and to obtain insight into disease mechanisms, we investigated the effect on electrophysiological properties of 59 of the variants in Xenopus oocytes using extended voltage and pH ranges. Detailed analyses revealed new pathophysiological mechanisms: 25% (15/59) of variants demonstrated LOF, characterized by a "shift" of the voltage-dependent activation to more positive voltages, and nine variants resulted in a toxic gain-of-function, associated with a disrupted gate allowing inward transport at negative voltages. Functional results were not always in line with in silico pathogenicity scores, highlighting the complexity of pathogenicity assessment for accurate genetic counselling. The complex neurocognitive and psychiatric manifestations of this condition, and hitherto under-recognized impacts on growth, gastrointestinal function, and motor control are discussed. Including published cases, we summarize features in 122 individuals from 67 families with CLCN4-related neurodevelopmental condition and suggest future research directions with the aim of improving the integrated care for individuals with this diagnosis.
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