| 1. |
- Berg, Gertrud, 1944, et al.
(författare)
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Development of severe thyroid-associated ophthalmopathy in a patient with disseminated thyroid cancer treated with recombinant human thyrotropin/radioiodine and retinoic acid.
- 2005
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Ingår i: Thyroid : official journal of the American Thyroid Association. - : Mary Ann Liebert Inc. - 1050-7256. ; 15:12, s. 1389-94
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Tidskriftsartikel (refereegranskat)abstract
- We present a case in which a patient with disseminated well-differentiated papillary thyroid cancer developed severe thyroid-associated ophthalmopathy. Eight years after initial surgery and ablative radioiodine therapy the patient was found to have multiple pulmonary metastases. The metastases showed poor uptake of radioiodine. An attempt was made to use 13-cis-retinoic acid in order to achieve a redifferentiation of the thyroid cancer cells before recombinant human thyrotropin (rhTSH) stimulated radioiodine therapy. The treatment did not improve the uptake of radioiodine. However, approximately 2 weeks after completion of the treatment the patient experienced discomfort in her eyes and then over the next months she developed a severe ophthalmopathy. The analyses of TSH receptor antibodies and S-thyroglobulin simultaneously showed a pronounced increase. An association between therapy given and severe ophthalmopathy cannot be excluded.
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| 2. |
- Biel, Anders, 1948, et al.
(författare)
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Behavioural Impediments to Sustainable Investment.
- 2007
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Ingår i: Paper presented at the 32nd IAREP Conference, Ljubljana, Slovenia..
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Konferensbidrag (refereegranskat)abstract
- The present study investigates impediments to sustainable investment (SI) that reside within the organizations of institutional investors. A questionnaire was addressed to 35 institutional investors with board directors, senior investment managers or portfolio managers acting as respondents. The respondents represented SI as well as non-SI funds. Presently, little is known about how variations in the endorsement of values and norms among members in an organisation affect decision making. We tested the hypothesis that to the extent that a SI policy has been adopted, members of the organisation share a norm to advance SI, driven by an adherence to social and environmental values, together with beliefs about potential benefits of SI. We also examined an alternative model assuming a direct link between beliefs about financial outcomes of SI and SI practices in the organisation.
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| 3. |
- Brandén Klang, Anders, et al.
(författare)
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Utvärdering av Trafikanalys uppföljning av de transportpolitiska målen
- 2024
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Ingår i: Sammanställning av referat från Transportforum 2024. - Linköping : Statens väg- och transportforskningsinstitut. ; , s. 55-55
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- 2017 redovisade Trafikanalys ett regeringsuppdrag där en del av uppdraget var att föreslå ett nytt system för sammanvägda bedömningar av utvecklingen på målnivå för de transportpolitiska målen. Den nya metoden har nu använts i fem måluppföljningar och hösten 2022 fick SWECO Sverige AB uppdraget att genomföra en enkät och intervjuundersökning bland måluppföljningens mottagargrupper för att inhämta synpunkter, åsikter och tankar kring måluppföljningens mått, metoder, resultat och kommunikation.Undersökningen genomfördes hösten 2022, och inleddes med en enkätundersökning skickad till 287 respondenter varav 152 (53%) svarade på enkätens frågor helt eller delvis. Enkäten följdes upp med intervjuer av 22 personer, varav 10 var från den högst prioriterade målgruppen som bestod av ledamöter i Riksdagens trafikutskott och tjänstemän på Regeringskansliet. Resultatet redovisades i en rapport till Trafikanalys under våren 2023, och det är dessa resultat som presenteras i detta föredrag. Generellt bedöms de indikatorer som används i måluppföljningen vara relevanta, och de flesta hyser förtroende för uppföljningen. Ett antal respondenter menar att sammanvägningsmodellen ger de mått som utvecklats negativt för stor relativbetydelse, och ett flertal respondenter tycker att Trafikanalys borde kommunicera måluppföljningens resultat på fler sätt och till bredare målgrupper. Måluppföljningen kan förbättras i vissa avseenden, bland annat genom att inkludera fler miljövärden och mer underlag som kopplar till godstransporter. Dessutom finns skäl att se över kommunikationen av uppföljningen och publiceringsformerna.
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| 4. |
- Cárdenas, Marité, et al.
(författare)
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DNA compaction by cationic surfactant in solution and at polystyrene particle solution interfaces: a dynamic light scattering study
- 2004
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Ingår i: Physical Chemistry Chemical Physics. - : Royal Society of Chemistry (RSC). - 1463-9084. ; 6:7, s. 1603-1607
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Tidskriftsartikel (refereegranskat)abstract
- The effect of cationic surfactant on the compaction of DNA both in bulk solution and on polystyrene particles has been studied by dynamic light scattering. DNA undergoes a transition from a semiflexible coil to a more compact globule in aqueous solution as a consequence of cationic surfactant binding. Thus the hydrodynamic radius of DNA decreases from 107 nm to about 50 nm in the presence of cationic surfactant. Such compaction is also observed on DNA coated polystyrene particles. In this case, the hydrodynamic layer thickness of DNA coated particles is reduced from 36 to 5 nm in the presence of cetyltrimethylammonium bromide.
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| 5. |
- Chorell, Elin, 1981-, et al.
(författare)
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Lysophospholipids as Predictive Markers of ST-Elevation Myocardial Infarction (STEMI) and Non-ST-Elevation Myocardial Infarction (NSTEMI)
- 2021
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Ingår i: Metabolites. - : MDPI. - 2218-1989 .- 2218-1989. ; 11:1
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Tidskriftsartikel (refereegranskat)abstract
- The present study explored patterns of circulating metabolites and proteins that can predict future risk for ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI). We conducted a prospective nested case-control study in northern Sweden in individuals who developed STEMI (N = 50) and NSTEMI (N = 50) within 5 years and individually matched controls (N = 100). Fasted plasma samples were subjected to multiplatform mass spectrometry-based metabolomics and multiplex protein analyses. Multivariate analyses were used to elucidate infarction-specific metabolite and protein risk profiles associated with future incident STEMI and NSTEMI. We found that altered lysophosphatidylcholine (LPC) to lysophosphatidylethanolamine (LPE) ratio predicted STEMI and NSTEMI events in different ways. In STEMI, lysophospholipids (mainly LPEs) were lower, whereas in NSTEMI, lysophospholipids (mainly LPEs) were higher. We found a similar response for all detected lysophospholipids but significant alterations only for those containing linoleic acid (C18:2, p < 0.05). Patients with STEMI had higher secretoglobin family 3A member 2 and tartrate-resistant acid phosphate type 5 and lower platelet-derived growth factor subunit A, which are proteins associated with atherosclerosis severity and plaque development mediated via altered phospholipid metabolism. In contrast, patients with NSTEMI had higher levels of proteins associated with inflammation and macrophage activation, including interleukin 6, C-reactive protein, chemerin, and cathepsin X and D. The STEMI risk marker profile includes factors closely related to the development of unstable plaque, including a higher LPC:LPE ratio, whereas NSTEMI is characterized by a lower LPC:LPE ratio and increased inflammation.
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| 6. |
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| 7. |
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| 8. |
- Erlandsson, Martin, et al.
(författare)
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Digital produktinformation baserat på datamallar : KONCEPTTEST MED MILJÖVARUDEKLARATIONER (EPD) OCH PRESTANDADEKLARATIONER (DOP) I WEBBTJÄNSTER (API)
- 2022
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- I framtiden måste vi bestämma oss för hur vi på ett rationellt, kvalitetssäkrat och digitalt sätt ska hantera produktinformation i byggsektorn. Visionen är att basera harmoniserad digital kvalitetsäkrad produktinformation på en internationellt användbar datamall.Grunderna för digitala datamallar och hur de tas fram beskrivs i standarderna ISO 23386/7 och ISO 23387.En ifylld datamall kallas ett datablad. I det här genomförda tillämpningstestet (proof of concept, PoC) av datamallar är syftet att kommunicera produktinformation digitalt i värdekedjan från materialtillverkan till dess att byggprodukten levererats till byggarbetsplatsen.I tillämpningstestet ingår flera materiatillverkare som har varit testpiloter för att ta fram datablad enligt datamalls-konceptet. Piloterna har tagit fram datablad för prestandadeklarationen (DoP) som är kopplat till produktens CE-märkning, samt för en EPD baserat på den globala datamallen som beskrivs i standarden ISO 22057.
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| 9. |
- Frohm, Magnus, et al.
(författare)
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Byssbon
- 1996
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Rapport (övrigt vetenskapligt/konstnärligt)
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| 10. |
- Gärling, Tommy, 1941, et al.
(författare)
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Behavioural impediments to sustainable investment.
- 2008
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Ingår i: Paper presented at the 16th annual conference of European Association of Environmental and Resource Economists (EARE), University of Gothenburg, Göteborg, Sweden..
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Konferensbidrag (refereegranskat)abstract
- Institutional investors are large and powerful owners of corporate equity and have, through their investment decisions, the potential to influence company behaviour in a more sustainable direction. How can institutional investors be influenced? There are many obstacles to overcome before such influences will become more widespread. The present study investigates impediments to sustainable investment (SI) that reside within and between organizations of institutional investors. A questionnaire was addressed to 37 institutional fund companies with board directors, senior investment managers, and portfolio managers acting as respondents. A main impediment within the organizations is that top and portfolio management differs in their view on SI. Although they have similar beliefs about short- and long-term returns of SI funds, top management has a more positive view on intangibles associated with SI. This includes to what extent one believes that members of the own organization support a norm that SI should be implemented and that the share of SI in the own company will increase in the future. The main impediment to SI practice may also be traced to incentives and rules that through imitation are adopted across organisations, potentially underlying the frequently observed herding behaviour among institutional investors. We therefore also present evidence for the hypothesis that herding is caused by interdependence between institutional investors, for instance, that leading investors or a critical mass of investors influence many others to follow suit.
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