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Sökning: WFRF:(Janz Nicole)

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1.
  • Díaz Reviriego, Isabel, et al. (författare)
  • Five years of IPBES : Reflecting the achievements and challenges and identifying needs for its review towards a 2nd work programme. 
  • 2018
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • On 17 to 19th October 2017, twenty-four academics and practitioners with diverse inter- and transdisciplinary experiences gathered for a workshop to collectively reflect on IPBES’ work and performance. The workshop was held at the German Centre for Integrative Biodiversity Research (iDiv) in Leipzig. The workshop and this report represent an effort to proactively contribute to IPBES’ ongoing (external) review process. The external review process opens up a window of opportunity towards re-thinking the very purpose of IPBES and identifying new pathways to live up to its initial ambitions, such as to move beyond assessments. The workshop identified a spectrum of potential opportunities, provided visions for the future work of IPBES, and collected insights into how to cope with them. While the workshop focussed on identifying future challenges and possible solutions, all participants underlined the great achievements that IPBES has already accomplished. This report provides a synthesis of the workshop discussions. The main recommendations for the external review were: - The external review should seize the opportunity to establish itself in a responsive and future-oriented way so that it not only assesses past performance but also facilitates learning and identifies new pathways for IPBES. It is important that the focus of the review is not just on the extent to which IPBES has fulfilled its ambitions but also on the efficiency with which it has done this, and on the potential unintended effects of decisions. - For IPBES to achieve its initial ambitions, strengthening the (mainly global-scale) scientific knowledge base behind assessments is necessary but not yet sufficient. To meet its broader set of goals, it is required to pay critical attention to all aspects of policy support, knowledge generation and capacity-building, including the meaningful participation of Indigenous Peoples and Local Communities and the incorporation of local and indigenous knowledge. This will require building synergies between knowledge systems, promoting the engagement of the social sciences and humanities, and addressing current challenges in the nomination and selection procedures for the identification of experts. - The external review also opens up space to identify a full range of alternative options and choices that are available when reforming IPBES. The review should engage in real-world dialogues and liaise closely with partners from research, policy and practice as well as with national platforms and local actors.
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2.
  • Lundgren, Markus, et al. (författare)
  • Analgesic antipyretic use among young children in the TEDDY study : No association with islet autoimmunity
  • 2017
  • Ingår i: BMC Pediatrics. - : Springer Science and Business Media LLC. - 1471-2431. ; 17:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: The use of analgesic antipyretics (ANAP) in children have long been a matter of controversy. Data on their practical use on an individual level has, however, been scarce. There are indications of possible effects on glucose homeostasis and immune function related to the use of ANAP. The aim of this study was to analyze patterns of analgesic antipyretic use across the clinical centers of The Environmental Determinants of Diabetes in the Young (TEDDY) prospective cohort study and test if ANAP use was a risk factor for islet autoimmunity. Methods: Data were collected for 8542 children in the first 2.5 years of life. Incidence was analyzed using logistic regression with country and first child status as independent variables. Holm's procedure was used to adjust for multiplicity of intercountry comparisons. Time to autoantibody seroconversion was analyzed using a Cox proportional hazards model with cumulative analgesic use as primary time dependent covariate of interest. For each categorization, a generalized estimating equation (GEE) approach was used. Results: Higher prevalence of ANAP use was found in the U.S. (95.7%) and Sweden (94.8%) compared to Finland (78.1%) and Germany (80.2%). First-born children were more commonly given acetaminophen (OR 1.26; 95% CI 1.07, 1.49; p = 0.007) but less commonly Non-Steroidal Anti-inflammatory Drugs (NSAID) (OR 0.86; 95% CI 0.78, 0.95; p = 0.002). Acetaminophen and NSAID use in the absence of fever and infection was more prevalent in the U.S. (40.4%; 26.3% of doses) compared to Sweden, Finland and Germany (p < 0.001). Acetaminophen or NSAID use before age 2.5 years did not predict development of islet autoimmunity by age 6 years (HR 1.02, 95% CI 0.99-1.09; p = 0.27). In a sub-analysis, acetaminophen use in children with fever weakly predicted development of islet autoimmunity by age 3 years (HR 1.05; 95% CI 1.01-1.09; p = 0.024). Conclusions: ANAP use in young children is not a risk factor for seroconversion by age 6 years. Use of ANAP is widespread in young children, and significantly higher in the U.S. compared to other study sites, where use is common also in absence of fever and infection.
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3.
  • Stephens, Lucas, et al. (författare)
  • Archaeological assessment reveals Earth’s early transformation through land use
  • 2019
  • Ingår i: Science. - : American Association for the Advancement of Science. - 0036-8075 .- 1095-9203. ; 365:6456, s. 897-902
  • Tidskriftsartikel (refereegranskat)abstract
    • Humans began to leave lasting impacts on Earth’s surface starting 10,000 to 8000 years ago. Through a synthetic collaboration with archaeologists around the globe, Stephens et al. compiled a comprehensive picture of the trajectory of human land use worldwide during the Holocene (see the Perspective by Roberts). Hunter-gatherers, farmers, and pastoralists transformed the face of Earth earlier and to a greater extent than has been widely appreciated, a transformation that was essentially global by 3000 years before the present.Science, this issue p. 897; see also p. 865Environmentally transformative human use of land accelerated with the emergence of agriculture, but the extent, trajectory, and implications of these early changes are not well understood. An empirical global assessment of land use from 10,000 years before the present (yr B.P.) to 1850 CE reveals a planet largely transformed by hunter-gatherers, farmers, and pastoralists by 3000 years ago, considerably earlier than the dates in the land-use reconstructions commonly used by Earth scientists. Synthesis of knowledge contributed by more than 250 archaeologists highlighted gaps in archaeological expertise and data quality, which peaked for 2000 yr B.P. and in traditionally studied and wealthier regions. Archaeological reconstruction of global land-use history illuminates the deep roots of Earth’s transformation and challenges the emerging Anthropocene paradigm that large-scale anthropogenic global environmental change is mostly a recent phenomenon.
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