| 1. |
- Ramklint, Mia, et al.
(författare)
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Assessing personality disorders in eating disordered patients using the SCID-II : Influence of measures and timing on prevalence rate
- 2010
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Ingår i: Personality and Individual Differences. - : Elsevier BV. - 0191-8869 .- 1873-3549. ; 48:2, s. 218-223
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Tidskriftsartikel (refereegranskat)abstract
- The SCID-II Personality Questionnaire is available as a screening tool to shorten the time it takes to perform the SCID-II interview. However, very little is known about combining the questionnaire with the interview in eating disordered individuals. The aim of this study was to examine the prevalence of personality disorder (PD) among patients with eating disorders (ED) by combining initial screening self-assessment with a later interview. not performed until axis I symptoms decreased. This was performed on 154 patients with ED. According to the initial self-assessment, the rate of any PD was 90%; however, according to the later SCID-II interview, the rate decreased to 37%. In a sub-sample of 15 patients, the questionnaire was filled out twice: at intake and at the time of the interview. In the subgroup performing the questionnaire twice, there was no decline in PD symptoms over time. However, the PD rate decreased significantly when the patient was assessed by the interview. These findings indicate that the influence of measures might be greater than the influence of timing. The findings support that prevalence rates of PD in eating disordered patients are high, but not as high as it has commonly been reported.
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| 2. |
- Ramklint, Mia, et al.
(författare)
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Guided self-help as the first step for bulimic symptoms : Implementation of a stepped-care model within specialized psychiatry
- 2012
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Ingår i: International Journal of Eating Disorders. - : Wiley. - 0276-3478 .- 1098-108X. ; 45:1, s. 70-78
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Tidskriftsartikel (refereegranskat)abstract
- Objective: This study describes the implementation and effectiveness of the first step, guided self-help (GSH), in a clinical setting, of a stepped-care model of cognitive behavior therapy for patients with bulimic symptoms. Method: Eighty-nine patients participated. Results: In the intent to-treat analyses, the effect sizes were small to moderate (0.25-0.66). However, the effect sizes were substantially larger (0.44-1.66) for the patients who completed all the GSH sessions (45%). The majority of non-completers stayed within psychiatric services. Supplementary treatments were mostly directed towards comorbid conditions, especially depression. Those discontinuing treatment in advance where characterized by more lifetime diagnoses and higher ratings on the restraint subscale of the EDE-Q. Discussion: GSH within specialized psychiatry might be effective for about 30% of the patients. There is no indication of patients losing their confidence in psychiatric services by being offered GSH as the first treatment.
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| 3. |
- Sjogren-Jansson, Eva, et al.
(författare)
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Production of human monoclonal antibodies in dialysis tubing
- 1991
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Ingår i: Hybridoma. - : Mary Ann Liebert Inc. - 0272-457X. ; 10:3, s. 411-419
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Tidskriftsartikel (refereegranskat)abstract
- Human x mouse hybridoma cells were grown in dialysis tubing (DT) to obtain large quantities of human monoclonal antibodies (MAb). Hybridoma cells were grown inside the DT, which was placed in a tissue culture flask containing medium. The medium inside the DT was supplemented with different additives which may be selected depending on the intended use of the MAb. About 10-50 times higher concentrations of immunoglobulin (Ig) were obtained after cultivation in DT compared to conventional tissue culture (CTC) for 2 days. The purity of the MAb was high which facilitated further antibody purification. Production of human MAb in DT proved to be excellent for evaluation studies in laboratory scale. It does not require expensive equipment and several hybridomas can be grown simultaneously.
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