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- Augustin, Livia S. A., et al.
(författare)
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Dietary Fibre Consensus from the International Carbohydrate Quality Consortium (ICQC)
- 2020
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Ingår i: Nutrients. - : MDPI. - 2072-6643. ; 12:9
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Tidskriftsartikel (refereegranskat)abstract
- Dietary fibre is a generic term describing non-absorbed plant carbohydrates and small amounts of associated non-carbohydrate components. The main contributors of fibre to the diet are the cell walls of plant tissues, which are supramolecular polymer networks containing variable proportions of cellulose, hemicelluloses, pectic substances, and non-carbohydrate components, such as lignin. Other contributors of fibre are the intracellular storage oligosaccharides, such as fructans. A distinction needs to be made between intrinsic sources of dietary fibre and purified forms of fibre, given that the three-dimensional matrix of the plant cell wall confers benefits beyond fibre isolates. Movement through the digestive tract modifies the cell wall structure and may affect the interactions with the colonic microbes (e.g., small intestinally non-absorbed carbohydrates are broken down by bacteria to short-chain fatty acids, absorbed by colonocytes). These aspects, combined with the fibre associated components (e.g., micronutrients, polyphenols, phytosterols, and phytoestrogens), may contribute to the health outcomes seen with the consumption of dietary fibre. Therefore, where possible, processing should minimise the degradation of the plant cell wall structures to preserve some of its benefits. Food labelling should include dietary fibre values and distinguish between intrinsic and added fibre. Labelling may also help achieve the recommended intake of 14 g/1000 kcal/day.
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- Dunlop, Malcolm G, et al.
(författare)
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Cumulative impact of 10 common genetic variants on colorectal cancer risk in 42,333 individuals from eight populations
- 2012
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Ingår i: Gut. - Stockholm : Karolinska Institutet, Dept of Molecular Medicine and Surgery. - 1468-3288 .- 0017-5749.
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: Colorectal cancer (CRC) has a substantial heritable component. Common genetic variation has been shown to contribute to CRC risk. A study was conducted in a large multi-population study to assess the feasibility of CRC risk prediction using common genetic variant data combined with other risk factors. A risk prediction model was built and applied to the Scottish population using available data. DESIGN: Nine populations of European descent were studied to develop and validate CRC risk prediction models. Binary logistic regression was used to assess the combined effect of age, gender, family history (FH) and genotypes at 10 susceptibility loci that individually only modestly influence CRC risk. Risk models were generated from case-control data incorporating genotypes alone (n=39 266) and in combination with gender, age and FH (n=11 324). Model discriminatory performance was assessed using 10-fold internal cross-validation and externally using 4187 independent samples. The 10-year absolute risk was estimated by modelling genotype and FH with age- and gender-specific population risks. RESULTS: The median number of risk alleles was greater in cases than controls (10 vs 9, p<2.2×10(-16)), confirmed in external validation sets (Sweden p=1.2×10(-6), Finland p=2×10(-5)). The mean per-allele increase in risk was 9% (OR 1.09; 95% CI 1.05 to 1.13). Discriminative performance was poor across the risk spectrum (area under curve for genotypes alone 0.57; area under curve for genotype/age/gender/FH 0.59). However, modelling genotype data, FH, age and gender with Scottish population data shows the practicalities of identifying a subgroup with >5% predicted 10-year absolute risk. CONCLUSION: Genotype data provide additional information that complements age, gender and FH as risk factors, but individualised genetic risk prediction is not currently feasible. Nonetheless, the modelling exercise suggests public health potential since it is possible to stratify the population into CRC risk categories, thereby informing targeted prevention and surveillance.
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- Huang, Chelsea X., et al.
(författare)
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TESS Spots a Hot Jupiter with an Inner Transiting Neptune
- 2020
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Ingår i: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8213 .- 2041-8205. ; 892:1
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Tidskriftsartikel (refereegranskat)abstract
- Hot Jupiters are rarely accompanied by other planets within a factor of a few in orbital distance. Previously, only two such systems have been found. Here, we report the discovery of a third system using data from the Transiting Exoplanet Survey Satellite (TESS). The host star, TOI-1130, is an eleventh magnitude K-dwarf in Gaia G-band. It has two transiting planets: a Neptune-sized planet (3.65 ± 0.10 R\oplus) with a 4.1 days period, and a hot Jupiter (1.50-0.22+0.27 RJ) with an 8.4 days period. Precise radial-velocity observations show that the mass of the hot Jupiter is 0.974-0.044+0.043 MJ. For the inner Neptune, the data provide only an upper limit on the mass of 0.17 MJ (3σ). Nevertheless, we are confident that the inner planet is real, based on follow-up ground-based photometry and adaptive-optics imaging that rule out other plausible sources of the TESS transit signal. The unusual planetary architecture of and the brightness of the host star make TOI-1130 a good test case for planet formation theories, and an attractive target for future spectroscopic observations.
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- Jenkins, Henry, et al.
(författare)
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Theorizing participatory intensities : A conversation about participation and politics
- 2013
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Ingår i: Convergence. The International Journal of Research into New Media Technologies. - 1354-8565 .- 1748-7382. ; 19:3, s. 265-286
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Tidskriftsartikel (refereegranskat)abstract
- This conversation started in Prague, the Czech Republic, during a panel moderated by Irena Reifova at the symposium 'On Empowered and Impassioned Audiences in the Age of Media Convergence'. The event was organized by the Faculty of Social Sciences at Charles University. The text contains a series of discussions. First, there is a conversation about the nature of the participatory democratic utopia and participatory culture and how groups take (or do not take) advantage of the affordances of new and emerging media. It also emphasizes the political nature and potential of popular culture and touches upon its connection to institutionalized politics. Three other key areas are mentioned: the role of different cultures of leadership, the significance of organizations in structuring participatory processes, and the need to enhance civic learning, providing more support for participatory cultures. This is combined with an interlocking discussion about the definition of participation and how it is tied up with power. It covers the differences between participation and interaction, engagement, interpretation, production, curation, and circulation. Finally, there is an underlying strand of discussion about the role of academia, focusing on the relationship between critical theory and cultural studies, the need to deconstruct our own frameworks and the question of which language to use to communicate academic research to the public.
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- Weible, Christopher M., et al.
(författare)
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Sharpening Advocacy Coalitions
- 2020
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Ingår i: Policy Studies Journal. - : Wiley. - 0190-292X .- 1541-0072. ; 48:4, s. 1054-1081
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Tidskriftsartikel (refereegranskat)abstract
- The concept of “advocacy coalitions” is the bedrock of the Advocacy Coalition Framework (ACF), one of the most established and successful approaches for understanding policy processes across the globe. This article revisits and sharpens the conceptual definition of advocacy coalitions. We summarize the lessons from its theoretical emphases under the ACF and specify its five attributes (policy actors, shared beliefs, coordination, resources, and stability). Through this specification, we identify the ideal coalition type and several coalition subtypes. We then clarify and make a distinction between how we think about coalitions as a concept and how we approach coalitions empirically. This article sharpens the lens for describing and explaining coalitions toward better observations, theorizing, and measurements. It ends with next steps for further deepening and broadening knowledge about advocacy coalitions.
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