| 1. |
- Hallin, Caroline, et al.
(författare)
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A comparative study of the effects of the 1872 storm and coastal flood risk management in denmark, germany, and sweden
- 2021
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Ingår i: Water. - : MDPI AG. - 2073-4441. ; 13:12
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Tidskriftsartikel (refereegranskat)abstract
- From November 12th to 13th in 1872, an extreme coastal flood event occurred in the south Baltic Sea. An unusual combination of winds created a storm surge reaching up to 3.5 m above mean sea level, which is more than a meter higher than all other observations over the past 200 years. On the Danish, German, and Swedish coasts, about 300 people lost their lives. The consequences of the storm in Denmark and Germany were more severe than in Sweden, with significantly larger destruction and higher numbers of casualties. In Denmark and Germany, the 1872 storm has been more extensively documented and remembered and still influences local and regional risk awareness. A comparative study indicates that the collective memory of the 1872 storm is related to the background knowledge about floods, the damage extent, and the response to the storm. Flood marks and dikes help to remember the events. In general, coastal flood defence is to the largest degree implemented in the affected areas in Germany, followed by Denmark, and is almost absent in Sweden, corresponding to the extent of the collective memory of the 1872 storm. Within the affected countries, there is local variability of flood risk awareness associated with the collective memory of the storm. Also, the economic dependency on flood-prone areas and conflicting interests with the tourism industry have influence on flood protection decisions. The processes of climate change adaptation and implementation of the EU Floods Directive are slowly removing these differences in flood risk management approaches.
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| 2. |
- Hallman, David, 1979-, et al.
(författare)
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Objectively measured sitting and standing in workers : Cross-sectional relationship with autonomic cardiac modulation
- 2019
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Ingår i: International Journal of Environmental Research and Public Health. - : MDPI AG. - 1661-7827 .- 1660-4601. ; 16:4
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Tidskriftsartikel (refereegranskat)abstract
- Excessive sitting and standing are proposed risk factors for cardiovascular diseases (CVDs), possibly due to autonomic imbalance. This study examines the association of objectively measured sitting and standing with nocturnal autonomic cardiac modulation. The cross-sectional study examined 490 blue-collar workers in three Danish occupational sectors. Sitting and standing during work and leisure were assessed during 1–5 days using accelerometers. Heart rate (HR) and heart rate variability (HRV) were obtained during nocturnal sleep as markers of resting autonomic modulation. The associations of sitting and standing still (h/day) with HR and HRV were assessed with linear regression models, adjusted for age, gender, body mass index, smoking, and physical activity. More sitting time during leisure was associated with elevated HR (p = 0.02), and showed a trend towards reduced HRV. More standing time at work was associated with lower HR (p = 0.02), and with increased parasympathetic indices of HRV (root mean squared successive differences of R-R intervals p = 0.05; high-frequency power p = 0.07). These findings, while cross-sectional and restricted to blue-collar workers, suggest that sitting at leisure is detrimental to autonomic cardiac modulation, but standing at work is beneficial. However, the small effect size is likely insufficient to mitigate the previously shown detrimental effects of prolonged standing on CVD.
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| 3. |
- Westergaard, David, et al.
(författare)
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Genome-wide association meta-analysis identifies five loci associated with postpartum hemorrhage.
- 2024
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Ingår i: Nature genetics. - 1546-1718.
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Tidskriftsartikel (refereegranskat)abstract
- Bleeding in early pregnancy and postpartum hemorrhage (PPH) bear substantial risks, with the former closely associated with pregnancy loss and the latter being the foremost cause of maternal death, underscoring the severe impact on maternal-fetal health. We identified five genetic loci linked to PPH in a meta-analysis. Functional annotation analysis indicated candidate genes HAND2, TBX3 and RAP2C/FRMD7 at three loci and showed that at each locus, associated variants were located within binding sites for progesterone receptors. There were strong genetic correlations with birth weight, gestational duration and uterine fibroids. Bleeding in early pregnancy yielded no genome-wide association signals but showed strong genetic correlation with various human traits, suggesting a potentially complex, polygenic etiology. Our results suggest that PPH is related to progesterone signaling dysregulation, whereas early bleeding is a complex trait associated with underlying health and possibly socioeconomic status and may include genetic factors that have not yet been identified.
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