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Search: WFRF:(Jeppesen Pia)

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1.
  • Cortese, Samuele, et al. (author)
  • Psychopharmacology in children and adolescents: unmet needs and opportunities
  • 2024
  • In: The Lancet Psychiatry. - 2215-0366 .- 2215-0374. ; 11:2, s. 143-154
  • Research review (peer-reviewed)abstract
    • Psychopharmacological treatment is an important component of the multimodal intervention approach to treating mental health conditions in children and adolescents. Currently, there are many unmet needs but also opportunities, alongside possible risks to consider, regarding the pharmacological treatment of mental health conditions in children and adolescents. In this Position Paper, we highlight and address these unmet needs and opportunities, including the perspectives of clinicians and researchers from the European College of Neuropsychopharmacology–Child and Adolescent Network, alongside those of experts by lived experience from national and international associations, via a survey involving 644 participants from 13 countries, and of regulators, through representation from the European Medicines Agency. We present and discuss the evidence base for medications currently used for mental disorders in children and adolescents, medications in the pipeline, opportunities in the development of novel medications, crucial priorities for the conduct of future clinical studies, challenges and opportunities in terms of the regulatory and legislative framework, and innovations in the way research is conducted, reported, and promoted.
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2.
  • Romare, Pia, et al. (author)
  • Spatial and temporal distribution of fish and zooplankton in a shallow lake
  • 2003
  • In: Freshwater Biology. - : Wiley. - 0046-5070. ; 48:8, s. 1353-1362
  • Journal article (peer-reviewed)abstract
    • 1. We performed both a large- and a small-scale echo sounding study on the spatial and temporal distribution of fish (mainly roach, Rutilus rutilus and perch, Perca fluviatlis), as well as a small-scale study of zooplankton distribution in the small, shallow and eutrophic Lake Hanebjerg in Denmark. In the small-scale study, sampling was conducted in open water as well as in the edge zone immediately outside two different types of vegetation. 2. Fish daytime abundances differed between the northern and the southern parts of the lake and, on a small scale, small fish aggregated in the edge zones during day, preferably outside dense emergent vegetation. Copepods avoided emergent vegetation, while cladocerans showed no habitat preference. Both small fish and cladoceran numbers were found to be higher during night than day. 3. The relative abundance (number per sample) of cladocerans in the edge zone immediately outside vegetation was negatively correlated with the relative abundance of fish in that zone. There was no correlation between cladoceran and fish abundance in open water, or between the relative abundance of copepods and fish. 4. The presence of pelagic piscivores in combination with avoidance behaviour of both fish and zooplankton is a likely explanation for the observed distribution of small fish and cladocerans in Lake Hanebjerg. Both small- and large-scale distribution patterns may be dependent on the type and distribution of complex structure in the lake. Even in a small lake, large-scale patterns may affect the interpretation of small-scale data.
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