| 1. |
- Bjursten, Henrik, et al.
(författare)
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Once after a full moon : acute type A aortic dissection and lunar phases
- 2022
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Ingår i: Interactive Cardiovascular and Thoracic Surgery. - : Oxford University Press. - 1569-9293 .- 1569-9285. ; 34:1, s. 105-110
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: Acute type A aortic dissection (ATAAD) is a rare but severe condition, routinely treated with emergent cardiac surgery. Many surgeons have the notion that patients with ATAAD tend to come in clusters, but no studies have examined these observations. This investigation was undertaken to study the potential association between the lunar cycle and the incidence of ATAAD.METHODS: We collected information on 2995 patients who underwent ATAAD surgery at centres from the Nordic Consortium for Acute Type A Aortic Dissection collaboration. We cross-referenced the time of surgery with lunar phase using a case-crossover design with 2 different definitions of full moon (>99% illumination and the 7-day full moon period).RESULTS: The period when the moon was illuminated the most (99% definition) did not show any significant increase in incidence for ATAAD surgery. However, when the full moon period was compared with all other moon phases, it yielded a relative risk of 1.08 [95% confidence interval (CI) 1.00-1.17, P = 0.057] and, compared to waxing moon, only the relative risk was 1.11 (95% CI 1.01-1.23, P = 0.027). The peak incidence came 4-6 days after the moon was fully illuminated.CONCLUSIONS: This study found an overrepresentation of surgery for ATAAD during the full moon phase. The explanation for this is not known, but we speculate that sleep deprivation during full moon leads to a temporary increase in blood pressure, which in turn could trigger rupture of the aortic wall. While this finding is interesting, it needs to be corroborated and the clinical implications are debateable.
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| 2. |
- Eliasson, Peter, et al.
(författare)
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An integrated design evaluation system supporting thermal-structural iterations
- 1998
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Ingår i: Concurrent Engineering - Research and Applications. - 1063-293X .- 1531-2003. ; 6:3, s. 179-187
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Tidskriftsartikel (refereegranskat)abstract
- In the design of high temperature components, design evaluation often requires an iterative procedure between thermal fluid and thermal structural simulations An integrated computer system providing an iterative environment for the multidisciplinary simulations re quired has been developed. The system supports iterations between thermal fluid and thermal structural simulations using two different commercial simulation packages. Traditionally, fluid and structural analysis have been simulated separately and analysis of coupled prob lems has required special, multidisciplinary simulation packages which are seldom used in early stages of design. Improving the infrastruc ture for data exchange between separate computer applications is one way to significantly reduce the lead time for design iterations. This reduction in lead-time allows multidisciplinary effects to be accounted for in early stages of design. The design system is demonstrated on an exhaust manifold, where the thermal interaction between fluid and structure is of significant importance. The commercial simulation tools have been integrated to demonstrate the effect of automised data flow on design methodology, i.e , de sign iterations. This integration method makes use of existing features in the simulation packages and uses an export file format as the neu tral exchange format. In this way, the integrated system is simple and fast to develop which is preferred in small prototype systems and de velopment project Database integration supports a tighter integration, but requires more development effort. For design systems, where several design tools need to communicate, standardised information management procedures are preferable, following the ideas of the STEP framework.
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| 3. |
- Isaksson, Ola, et al.
(författare)
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Trends in product modelling : an ENDREA perspective
- 2000
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Ingår i: Proceedings / Produktmodeller 2000. - Linköping : Linköping universitet.
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Konferensbidrag (refereegranskat)abstract
- The success of engineering companies is highly dependent on how well product information is managed, engineered and communicated. From marketing through development to after sales activities, data needs to be accessible and used in the best way. Today, geographical distance, the need for close co-operation and data complexity are all natural parts of the working environment. Product modelling techniques are continuously evolving with new requirements and opportunities emerging daily. This paper will outline and discuss some of these trends, and at the same time present some of the areas where research is being carried out within projects in the Product Model Cluster in the national graduate school - The Swedish Engineering Design Research and Education Agenda (ENDREA).
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| 4. |
- Moberg, Christina, et al.
(författare)
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De unga gör helt rätt när de stämmer staten
- 2022
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Ingår i: Aftonbladet. - 1103-9000.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
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| 5. |
- Oudin, Anna, et al.
(författare)
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Impact of national holidays and weekends on incidence of acute type A aortic dissection repair
- 2022
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Ingår i: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 12:1
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Tidskriftsartikel (refereegranskat)abstract
- Previous studies have demonstrated that environmental and temporal factors may affect the incidence of acute type A aortic dissection (ATAAD). Here, we aimed to investigate the hypothesis that national holidays and weekends influence the incidence of surgery for ATAAD. For the period 1st of January 2005 until 31st of December 2019, we investigated a hypothesised effect of (country-specific) national holidays and weekends on the frequency of 2995 surgical repairs for ATAAD at 10 Nordic cities included in the Nordic Consortium for Acute Type A Aortic Dissection (NORCAAD) collaboration. Compared to other days, the number of ATAAD repairs were 29% (RR 0.71; 95% CI 0.54–0.94) lower on national holidays and 26% (RR 0.74; 95% CI 0.68–0.82) lower on weekends. As day of week patterns of symptom duration were assessed and the primary analyses were adjusted for period of year, our findings suggest that the reduced surgical incidence on national holidays and weekends does not seem to correspond to seasonal effects or surgery being delayed and performed on regular working days.
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| 6. |
- Törlind, Peter, et al.
(författare)
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Collaboration environments for distributed engineering : development of a prototype system
- 1999
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Ingår i: Proceedings of Fourth International Workshop on CSCW in Design. - Compiègne : Université de Technologique de Compiègne. - 2913923003
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Konferensbidrag (refereegranskat)abstract
- In this paper we propose a model for collaboration between engineers in a distributed environment based on a suite of specialized computer tools. The system is built around the distributed virtual reality system DIVE that has been customized for interoperability with existing CAD systems. Other tools supporting the information exchange process in a product development project include audio/video conferencing software, shared workspace systems for document sharing, application sharing tools, shared whiteboard applications and more. The paper discusses the components of the collaboration environment both from a technical standpoint as well as in respect to usability issues.
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| 7. |
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| 8. |
- Andersson, Henrik, et al.
(författare)
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Assaying cardiac biomarkers for toxicity testing using biosensing and cardiomyocytes derived from human embryonic stem cells
- 2010
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Ingår i: JOURNAL OF BIOTECHNOLOGY. - : Elsevier Science B.V., Amsterdam.. - 0168-1656 .- 1873-4863. ; 150:1, s. 175-181
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Tidskriftsartikel (refereegranskat)abstract
- Human embryonic stem cell (hESC) derived cardiomyocytes are in the present study being used for testing drug-induced cardiotoxicity in a biosensor set-up. The design of an in vitro testing alternative provides a novel opportunity to surpass previous methods based on rodent cells or cell lines due to its significantly higher toxicological relevance. In this report we demonstrate how hESC-derived cardiomyocytes release detectable levels of two clinically decisive cardiac biomarkers, cardiac troponin T and fatty acid binding protein 3, when the cardiac cells are exposed to the well-known cardioactive drug compound. doxorubicin. The release is monitored by the immuno-biosensor technique surface plasmon resonance, particularly appropriate due to its capacity for parallel and high-throughput analysis in complex media.
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| 9. |
- Andersson, Magnus V., et al.
(författare)
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Kirurgi – omistligt komplement till medicinsk behandling
- 2009
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Ingår i: Läkartidningen. - 0023-7205 .- 1652-7518. ; 106:45, s. 3003-9
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Tidskriftsartikel (refereegranskat)abstract
- Kirurgi på rätt indikation och vid rätt tidpunkt är ett omistligt komplement till medicinsk behandling vid inflammatorisk tarmsjukdom, som förebygger sjukdomskomplikationer, förbättrar patienternas livskvalitet och ibland är livräddande. Kirurgi för ulcerös kolit görs oftast som ett tvåstegsförfarande: först kolektomi plus ileostomi med rektum lämnad intakt och i senare skede, med optimerad patient, tarmrekonstruktion anpassad efter patientens individuella livssituation. Kirurgi vid Crohns sjukdom korrigerar komplikationer (stenoser och fistlar) och sparar tarm genom begränsade resektioner och strikturplastiker. Laparoskopisk kirurgi verkar ha viktiga fördelar vid primära tarmresektioner. Modern medicinsk behandling har förändrat indikationerna men ännu inte minskat behovet av kirurgi. Pågående antiinflammatorisk och immunmodulerande behandling är viktig att beakta i samband med kirurgi. Ett nära samspel mellan gastroenterolog och kolorektalkirurg är nödvändigt för att uppnå bästa möjliga långtidsprognos för de individer som lever med IBD.
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| 10. |
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