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- Wu, Chen, et al.
(författare)
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Genome-wide association study of survival in patients with pancreatic adenocarcinoma
- 2014
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Ingår i: Gut. - : BMJ Publishing Group. - 0017-5749 .- 1468-3288. ; 63:1, s. 152-160
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND AND OBJECTIVE: Survival of patients with pancreatic adenocarcinoma is limited and few prognostic factors are known. We conducted a two-stage genome-wide association study (GWAS) to identify germline variants associated with survival in patients with pancreatic adenocarcinoma. METHODS: We analysed overall survival in relation to single nucleotide polymorphisms (SNPs) among 1005 patients from two large GWAS datasets, PanScan I and ChinaPC. Cox proportional hazards regression was used in an additive genetic model with adjustment for age, sex, clinical stage and the top four principal components of population stratification. The first stage included 642 cases of European ancestry (PanScan), from which the top SNPs (p≤10(-5)) were advanced to a joint analysis with 363 additional patients from China (ChinaPC). RESULTS: In the first stage of cases of European descent, the top-ranked loci were at chromosomes 11p15.4, 18p11.21 and 1p36.13, tagged by rs12362504 (p=1.63×10(-7)), rs981621 (p=1.65×10(-7)) and rs16861827 (p=3.75×10(-7)), respectively. 131 SNPs with p≤10(-5) were advanced to a joint analysis with cases from the ChinaPC study. In the joint analysis, the top-ranked SNP was rs10500715 (minor allele frequency, 0.37; p=1.72×10(-7)) on chromosome 11p15.4, which is intronic to the SET binding factor 2 (SBF2) gene. The HR (95% CI) for death was 0.74 (0.66 to 0.84) in PanScan I, 0.79 (0.65 to 0.97) in ChinaPC and 0.76 (0.68 to 0.84) in the joint analysis. CONCLUSIONS: Germline genetic variation in the SBF2 locus was associated with overall survival in patients with pancreatic adenocarcinoma of European and Asian ancestry. This association should be investigated in additional large patient cohorts.
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- Zhang, Haiyan, et al.
(författare)
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Facile preparation of glutathione-stabilized gold nanoclusters for selective determination of chromium (III) and chromium (VI) in environmental water samples
- 2013
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Ingår i: Analytica Chimica Acta. - : Elsevier BV. - 0003-2670 .- 1873-4324. ; 770, s. 140-146
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Tidskriftsartikel (refereegranskat)abstract
- A novel method for selective determination of Cr(III) and Cr(VI) in environmental water samples was developed based on target-induced fluorescence quenching of glutathione-stabilized gold nanoclusters (GSH-Au NCs). Fluorescent GSH-Au NCs were synthesized by a one-step approach employing GSH as reducing/protecting reagent. It was found that Cr(III) and Cr(VI) showed pH-dependent fluorescence quenching capabilities for GSH-Au NCs, and thus selective determination of Cr(III) and Cr(VI) could be achieved at different pHs. Addition of EDTA was able to effectively eliminate the interferences from other metal ions, leading to a good selectivity for this method. Under optimized conditions, Cr(III) showed a linear range of 25-3800 μg L(-1) and a limit of detection (LOD) of 2.5 μg L(-1). The Cr(VI) ion demonstrated a linear range of 5-500 μg L(-1) and LOD of 0.5 μg L(-1). The run-to-run relative standard deviations (n=5) for Cr(III) and Cr(VI) were 3.9% and 2.8%, respectively. The recoveries of Cr(III) and Cr(VI) in environmental water samples were also satisfactory (76.3-116%). This method, with its simplicity, low cost, high selectivity and sensitivity, could be used as a promising tool for chromium analysis in environmental water samples.
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- Zhao, Zongshan, et al.
(författare)
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Source and migration of short-chain chlorinated paraffins in the coastal East China Sea using multiproxies of marine organic geochemistry
- 2013
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Ingår i: Environmental Science and Technology. - : American Chemical Society (ACS). - 0013-936X .- 1520-5851. ; 47:10, s. 5013-5022
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Tidskriftsartikel (refereegranskat)abstract
- Multiple proxies of terrestrial organic matters (TOM) were introduced to study the migration behaviors of short-chain chlorinated paraffins (SCCPs) in the coastal East China Sea (ECS). The contents of SCCPs in the surface sediment collected from Changjiang (Yangtze) River Delta (CRD) and along the Zhejiang-Fujian coastline ranged from 9.0 to 37.2 ng/g (dry weight, d.w.), displaying a "band-style" distribution trend. Spatial distribution patterns of SCCP congeners presented an increasing trend seaward and southward along the coastline for shorter carbon length (C₁₀ + C₁₁) and lower chlorinated (Cl₅ + Cl₆ + Cl₇) congeners, suggesting a spreading tendency seaward and southward from the CRD and the north of the inner shelf. The significant relationship between ΣSCCPs and total organic carbons (TOC) (r(2) = 0.402, p < 0.05) indicated that the migration of SCCPs in sediments was markedly affected by TOC. The spatial patterns of the TOM proxies of TOC δ(13)C, the contents of ΣC₂₇ + C₂₉ + C₃₁ n-alkanes, terrestrial marine biomarker ratio (TMBR), and terrestrial TOC (T-TOC) were all similar to that of ΣSCCPs. Linear relationships between SCCP contents and both the contents of ΣC₂₇ + C₂₉ + C₃₁ n-alkanes (r(2) = 0.537, p < 0.05) and T-TOC (r(2) = 0.495, p < 0.05) were also observed. The consistence demonstrated that a major portion of sedimentary SCCPs in the coastal ECS should be from the river input of Changjiang River and deposited in the CRD and along the inner shelf of the ECS, but only a minor fraction was transported to the offshore areas.
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