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Träfflista för sökning "WFRF:(Jiang Shang Chuan) "

Sökning: WFRF:(Jiang Shang Chuan)

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  • Hong, Jun, et al. (författare)
  • Moving genome edited crops forward from the laboratory bench to the kitchen table
  • 2021
  • Ingår i: Food Control. - : Elsevier. - 0956-7135 .- 1873-7129. ; 122
  • Forskningsöversikt (refereegranskat)abstract
    • Targeted nuclease based genome editing technology particularly clustered regularly interspaced short palindromic repeats (CRISPR) that allows to manipulate virtually almost any genomic sequences has greatly facilitated both basic and applied researches in plants. However, so far, very few of them has entered to the field and much less to the kitchen table. This review starts with a brief summary of current status of the application of genome editing in crop science and crop breeding and, then identifies technical, ethical, intellectual and other challenges for the commercialization of genome edited crops. This review explores further advances in the specificity and the prediction and detection of off-targets of CRISPR system, and highlights the importance of molecular characterization and the introduction of novel techniques such as nanotechnology to CRISPR system. Finally, this review calls for collaborative efforts in proposing principles and guidelines for moving genome edited crops forward from the laboratory bench to the kitchen table, and emphasizes the equal importance of public outreach.
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  • Lin, Tzung-Sheng, et al. (författare)
  • Sulfation pattern of chondroitin sulfate in human osteoarthritis cartilages reveals a lower level of chondroitin-4-sulfate
  • 2020
  • Ingår i: Carbohydrate Polymers. - : Elsevier. - 0144-8617 .- 1879-1344. ; 229
  • Tidskriftsartikel (refereegranskat)abstract
    • Chondroitin sulfates (CS) account for more than 80% of glycosaminoglycans of articular cartilage, which imparts its physiological functions. We quantified the absolute concentration of the CS components of the full thickness cartilages from the knees of patients with terminal-phase osteoarthritis. Osteochondrol biopsies were removed from the medial femoral condyle and lateral femoral condyle of sixty female patients receiving total knee arthroplasty, aged from 58 to 83 years old. We found that total CS concentrations and chondroitin-4-sulfate disaccharide were significantly lowered in osteoarthritic samples. Microstructure analysis indicated that while chondroitin-0-sulfate was equally distributed across different zones of the osteoarthritic cartilages, chondroitin-4-sulfate is significantly less in the deep zones. Down-regulation of sulfotransferases, the enzymes responsible for CS sulfation in the lesion site of cartilage were observed. Our study suggested chondroitin-4-sulfate down-regulation may be a diagnostic marker for degraded osteoarthritis cartilage, with potential implications in cartilage regeneration.
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