| 1. |
- Zhou, Ping, et al.
(författare)
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Molecular characterization of transcriptome-wide interactions between highly pathogenic porcine reproductive and respiratory syndrome virus and porcine alveolar macrophages in vivo
- 2011
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Ingår i: International Journal of Biological Sciences. - 1449-2288. ; 7:7, s. 947-959
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Tidskriftsartikel (refereegranskat)abstract
- Porcine reproductive and respiratory syndrome virus (PRRSV) infects mainly the porcine alveolar macrophages (PAMs) and causes porcine reproductive and respiratory syndrome (PRRS). Previous studies have analyzed the global gene expression profiles of lung tissue in vivo and PAMs in vitro following infection with PRRSV, however, transcriptome-wide understanding of the interaction between highly pathogenic PRRSV (HP-PRRSV) and PAMs in vivo has not yet been established. In this study, we employed Affymetrix microarrays to investigate the gene expression patterns of PAMs isolated from Tongcheng piglets (a Chinese indigenous breed) after infection with HP-PRRSV. During the infection, Tongcheng piglets exhibited typical clinical signs, e.g. fever, asthma, coughing, anorexia, lethargy and convulsion, but displayed mild regional lung damage at 5 and 7 dpi. Microarray analysis revealed that HP-PRRSV infection has affected PAMs in expression of the important genes involved in cytoskeleton and exocytosis organization, protein degradation and folding, intracellular calcium and zinc homeostasis. Several potential antiviral strategies might be employed in PAMs, including upregulating IFN-induced genes and increasing intracellular zinc ion concentration. And inhibition of the complement system likely attenuated the lung damage during HP-PRRSV infection. Transcriptomic analysis of PAMs in vivo could lead to a better understanding of the HP-PRRSV-host interaction, and to the identification of novel antiviral therapies and genetic components of swine tolerance/susceptibility to HP-PRRS.
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| 2. |
- Wang, Xiaohang, et al.
(författare)
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Fine-grained runtime power budgeting for networks-on-chip
- 2015
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Ingår i: 0th Asia and South Pacific Design Automation Conference, ASP-DAC 2015. - : Institute of Electrical and Electronics Engineers (IEEE). - 9781479977901 ; , s. 160-165
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Konferensbidrag (refereegranskat)abstract
- Power budgeting for NoC needs to be performed to meet limited power budget while assuring the best possible overall system performance. For simplicity and ease of implementation, existing NoC power budgeting schemes, irrespective of the fact that the packet arrival rates of different NoC routers may vary significantly, treat all the individual routers indiscriminately when allocating power to them. However, such homogeneous power allocation may provide excess power to routers with low packet arrival rates whereas insufficient power to those with high arrival rates. In this paper, we formulate the NoC power budgeting problem as to optimize the network performance over a power budget through per-router frequency scaling, taking into account of heterogeneous packet arrival rates across different routers as imposed by run time traffic dynamics. Correspondingly, we propose a fine-grained solution using an agile dynamic programming network with a linear time complexity. In essence, frequency of a router is set individually according to its contribution to the average network latency while meeting the power budget. Experimental results have confirmed that with fairly low runtime and hardware overhead, the proposed scheme can help save up to 50% application execution time when compared with the best existing methods.
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