| 1. |
- Luo, Yifei, et al.
(författare)
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Technology Roadmap for Flexible Sensors
- 2023
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Ingår i: ACS Nano. - : American Chemical Society. - 1936-0851 .- 1936-086X. ; 17:6, s. 5211-5295
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Forskningsöversikt (refereegranskat)abstract
- Humans rely increasingly on sensors to address grand challenges and to improve quality of life in the era of digitalization and big data. For ubiquitous sensing, flexible sensors are developed to overcome the limitations of conventional rigid counterparts. Despite rapid advancement in bench-side research over the last decade, the market adoption of flexible sensors remains limited. To ease and to expedite their deployment, here, we identify bottlenecks hindering the maturation of flexible sensors and propose promising solutions. We first analyze challenges in achieving satisfactory sensing performance for real-world applications and then summarize issues in compatible sensor-biology interfaces, followed by brief discussions on powering and connecting sensor networks. Issues en route to commercialization and for sustainable growth of the sector are also analyzed, highlighting environmental concerns and emphasizing nontechnical issues such as business, regulatory, and ethical considerations. Additionally, we look at future intelligent flexible sensors. In proposing a comprehensive roadmap, we hope to steer research efforts towards common goals and to guide coordinated development strategies from disparate communities. Through such collaborative efforts, scientific breakthroughs can be made sooner and capitalized for the betterment of humanity.
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| 2. |
- Holden, Stein T., et al.
(författare)
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Tenure Security and Investment Effects of Forest Tenure Reform in China
- 2013
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Ingår i: Land Tenure Reform in Asia and Africa: assessing impacts on poverty and natural resource management / edited by Stein T. Holden, Keijiro Otsuka and Klaus Deininger... - UK : Palgrave Macmillan. - 9781137343802 ; , s. 256-282
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Bokkapitel (refereegranskat)abstract
- http://www.palgraveconnect.com/pc/doifinder/10.1057/9781137343819.0020
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| 3. |
- Ji, Xuemei, et al.
(författare)
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Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk
- 2018
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Ingår i: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 9, s. 1-15
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and lung expression quantitative trait loci (eQTL) data on 409 individuals to identify and validate the underlying pathways and to investigate the combined effect of genes from the identified susceptibility pathways. The KEGG neuroactive ligand receptor interaction pathway, two Reactome pathways, and 22 Gene Ontology terms were identified and replicated to be significantly associated with lung cancer risk, with P values less than 0.05 and FDR less than 0.1. Functional annotation of eQTL analysis results showed that the neuroactive ligand receptor interaction pathway and gated channel activity were involved in lung cancer risk. These pathways provide important insights for the etiology of lung cancer.
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| 4. |
- Jiang, Xuemei, et al.
(författare)
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Impacts of Policy Measures on the Development of State Owned Forests in Northeast China : Theoretical Results and Empirical Evidence
- 2014
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Ingår i: Environment and Development Economics. - : Cambridge University Press. - 1355-770X .- 1469-4395. ; 19, s. 74-91
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Tidskriftsartikel (refereegranskat)abstract
- State-owned forest enterprises (SOFEs) in northeast China play important roles both in timber production and in the maintenance of ecological security. This paper examines the effects of a number of policy measures on the behavioral choices of the SOFEs. The results show that the extent to which SOFE supervising authorities emphasized the improvement of forest resources in their annual evaluation of the SOFEs had significant impacts on the harvest and investment decisions and the development of forest resources. Promotion of the management and utilization of non-timber resources, as well as reforms aiming to increase the efficiency of forest protection and management, reduced timber harvests and increased investment, which in turn led to improvements of forest resources, although the effects were small. In contrast, reforms aimed at timber harvest and afforestation activities actually contributed to increasing timber harvest, which affected the development of the forest resources negatively.
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| 5. |
- Jiang, Xuemei, et al.
(författare)
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Impacts of policy measures on the development of state-owned forests in Northeast China : Theoretical results and empirical evidence
- 2011
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- State-owned forest enterprises (SOFEs) in northeast China and Inner Mongolia play important roles both in timber production and in the maintenance of ecological security. However, since the late 1970s, forest resource and economic crises have seriously restricted these functions. Based on a theoretical and an empirical analysis of the harvest and investment behavior of the SOFEs, we examined the effects of forest policies and the socioeconomic conditions on the behavioral choices of the SOFEs. Both the extent to which SOFE supervising authorities emphasized improvement of forest resources in their annual evaluations and the increases in expenses necessary to manage SOFEs had significant impacts on harvest and investment decisions as well as development of forest resources. Promoting the management and utilization of non-timber resources, as well as reforms to increase the efficiency of forest protection and management, have reduced timber harvests as intended, which in turn has increased investment and improved forest resources. The effects have been relatively small, however. In contrast, reforms aimed at timber harvest and afforestation activities actually contributed toincreasing the timber harvest, which affected the development of the forest resources negatively.
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| 6. |
- Luyapan, Jennifer, et al.
(författare)
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A new efficient method to detect genetic interactions for lung cancer GWAS
- 2020
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Ingår i: BMC Medical Genomics. - : Springer Science and Business Media LLC. - 1755-8794. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Genome-wide association studies (GWAS) have proven successful in predicting genetic risk of disease using single-locus models; however, identifying single nucleotide polymorphism (SNP) interactions at the genome-wide scale is limited due to computational and statistical challenges. We addressed the computational burden encountered when detecting SNP interactions for survival analysis, such as age of disease-onset. To confront this problem, we developed a novel algorithm, called the Efficient Survival Multifactor Dimensionality Reduction (ES-MDR) method, which used Martingale Residuals as the outcome parameter to estimate survival outcomes, and implemented the Quantitative Multifactor Dimensionality Reduction method to identify significant interactions associated with age of disease-onset. Methods: To demonstrate efficacy, we evaluated this method on two simulation data sets to estimate the type I error rate and power. Simulations showed that ES-MDR identified interactions using less computational workload and allowed for adjustment of covariates. We applied ES-MDR on the OncoArray-TRICL Consortium data with 14,935 cases and 12,787 controls for lung cancer (SNPs = 108,254) to search over all two-way interactions to identify genetic interactions associated with lung cancer age-of-onset. We tested the best model in an independent data set from the OncoArray-TRICL data. Results: Our experiment on the OncoArray-TRICL data identified many one-way and two-way models with a single-base deletion in the noncoding region of BRCA1 (HR 1.24, P = 3.15 × 10–15), as the top marker to predict age of lung cancer onset. Conclusions: From the results of our extensive simulations and analysis of a large GWAS study, we demonstrated that our method is an efficient algorithm that identified genetic interactions to include in our models to predict survival outcomes.
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| 7. |
- McKay, James D., et al.
(författare)
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Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes
- 2017
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Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 49:7, s. 1126-1132
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Tidskriftsartikel (refereegranskat)abstract
- Although several lung cancer susceptibility loci have been identified, much of the heritability for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European descent were genotyped on the OncoArray and combined with existing data for an aggregated genomewide association study (GWAS) analysis of lung cancer in 29,266 cases and 56,450 controls. We identified 18 susceptibility loci achieving genome-wide significance, including 10 new loci. The new loci highlight the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer, with four loci associated with lung cancer overall and six loci associated with lung adenocarcinoma. Gene expression quantitative trait locus (eQTL) analysis in 1,425 normal lung tissue samples highlights RNASET2, SECISBP2L and NRG1 as candidate genes. Other loci include genes such as a cholinergic nicotinic receptor, CHRNA2, and the telomere-related genes OFBC1 and RTEL1. Further exploration of the target genes will continue to provide new insights into the etiology of lung cancer.
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| 8. |
- Wang, Yawei, et al.
(författare)
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Effect of municipal sewage treatment plant effluent on bioaccumulation of polychlorinated biphenyls and polybrominated diphenyl ethers in the recipient water
- 2007
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Ingår i: Environmental Science and Technology. - : American Chemical Society (ACS). - 0013-936X .- 1520-5851. ; 41:17, s. 6026-6032
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Tidskriftsartikel (refereegranskat)abstract
- Water, sediment, and aquatic species including plankton, fish, and turtles were collected from a small lake in Beijing, which receives effluent discharged from a large sewage treatment plant (STP). The samples were examined to investigate polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) releases from a STP and their distributions in the lake. The accumulations of ∑12PBDEs and BDE-209 in the sediment were 62.3 and 1150 ng/cm2, respectively, while that of ∑PCBs was 99.3 ng/cm2. BDE-209 was detected in more than 50% of the aquatic species. A strong linear correlation (R2 = 0.92) was found between ∑12PBDEs and ∑PCBs levels in aquatic species but not in sediments. The different PBDE congener profiles in sediments and biota samples suggest metabolic debromination in the sampled fish. Bioaccumulations of PBDEs and PCBs were found in aquatic species.The logarithm bioaccumulation factor (BAF) decreases with the number of bromines in PBDEs molecules, while the log BAF versus the number of chlorines in PCBs appears to be parabolic. Biomagnifications of these compounds were not obvious in the food web by analysis of the relationship between ∑12PBDEs or ∑PCBs levels and the trophic level of aquatic biota species.
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