| 1. |
- Bernal, Ximena E., et al.
(författare)
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Empowering Latina scientists
- 2019
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 363:6429, s. 825-826
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 2. |
- Burgos-Ayala, Aracely, et al.
(författare)
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Indigenous and local knowledge in environmental management for human-nature connectedness : a leverage points perspective
- 2020
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Ingår i: Ecosystems and People. - : Informa UK Limited. - 2639-5908 .- 2639-5916. ; 16:1, s. 290-303
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Tidskriftsartikel (refereegranskat)abstract
- Indigenous peoples are key actors for environmental management because they hold valuable indigenous and local knowledge (ILK) for the sustainable stewardship of nature. However, the consideration of ILK in environmental management is still limited. We explore how environmental government institutions in Colombia have involved indigenous communities in 2212 environmental management projects between 2004 and 2015. Only 1% of these projects involved indigenous peoples as main actors. We applied the Leverage Points (LP) perspective in a content analysis to identify ‘where’ and ‘how’ these projects promote transformative changes within indigenous territories. Moreover, we investigated the interactions between projects targeting shallow and deep LP using cluster analysis. Our results show that these projects mainly seek to improve the well-being of indigenous peoples and consider ILK in their interventions, which suggests changes in deep LP. Additionally, these projects usually combined interventions targeting both shallow and deep LP while using ILK to improve environmental management practices (e.g., Life Plans) and developing participatory land-use planning in the indigenous territories. We argue that the involvement of ILK in environmental management can lead to stronger human–nature connectedness and thus to more successful conservation policies. However, this involvement is still at an early stage in Colombia.
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| 3. |
- Hudson, Lawrence N, et al.
(författare)
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The database of the PREDICTS (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems) project
- 2017
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Ingår i: Ecology and Evolution. - : John Wiley & Sons. - 2045-7758. ; 7:1, s. 145-188
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Tidskriftsartikel (refereegranskat)abstract
- The PREDICTS project-Projecting Responses of Ecological Diversity In Changing Terrestrial Systems (www.predicts.org.uk)-has collated from published studies a large, reasonably representative database of comparable samples of biodiversity from multiple sites that differ in the nature or intensity of human impacts relating to land use. We have used this evidence base to develop global and regional statistical models of how local biodiversity responds to these measures. We describe and make freely available this 2016 release of the database, containing more than 3.2 million records sampled at over 26,000 locations and representing over 47,000 species. We outline how the database can help in answering a range of questions in ecology and conservation biology. To our knowledge, this is the largest and most geographically and taxonomically representative database of spatial comparisons of biodiversity that has been collated to date; it will be useful to researchers and international efforts wishing to model and understand the global status of biodiversity.
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| 4. |
- Jiménez, Marcela, et al.
(författare)
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Assessing the historical adaptive cycles of an urban social-ecological system and its potential future resilience : the case of Xochimilco, Mexico City
- 2020
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Ingår i: Regional Environmental Change. - : Springer Science and Business Media LLC. - 1436-3798 .- 1436-378X. ; 20:1
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Tidskriftsartikel (refereegranskat)abstract
- As the bulk of the world’s population becomes urban, maintaining urban ecosystem services for environmental and social well-being in cities is crucial. According to resilience theory, maintaining such services requires for a complex adaptive systems perspective that helps in identifying key elements and dynamics behind cross-scale social-ecological interactions. In this context, the objective of this article is to use a resilience “lens” to problematize the imminent loss of an urban wetland using the adaptive cycle model as a heuristic tool. Our case study focuses on the Xochimilco wetland, located in the southern periphery of Mexico City. Xochimilco is characterized by the presence of a complex system of raised bed wetland agriculture (the chinampa system), which was established over 1000 years ago; currently, despite having a recognized cultural and environmental value, it is threatened by increasing urban sprawl, over-exploitation of the aquifer, and water contamination. By conducting a historical analysis of the Xochimilco social-ecological system, we assess how it has gone through phases of the adaptive cycle. As a result, we identify critical elements of the system’s historically maintained resilience and main drivers of system change. From such findings, we present some insights on the possibilities of maintaining the system’s resilience and guidance for future management strategies for the Xochimilco wetland. Lastly, we reflect on the scope and limitations of using a resilience-based approach and an adaptive cycle analysis for addressing urban sustainability problems, especially in cities in the Global South.
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| 5. |
- Klionsky, Daniel J., et al.
(författare)
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Guidelines for the use and interpretation of assays for monitoring autophagy
- 2012
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Ingår i: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 8:4, s. 445-544
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Forskningsöversikt (refereegranskat)abstract
- In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
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| 6. |
- Maitre, Léa, et al.
(författare)
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State-of-the-art methods for exposure-health studies: Results from the exposome data challenge event
- 2022
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Ingår i: Environment International. - : Elsevier BV. - 0160-4120 .- 1873-6750. ; 168
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Tidskriftsartikel (refereegranskat)abstract
- The exposome recognizes that individuals are exposed simultaneously to a multitude of different environmental factors and takes a holistic approach to the discovery of etiological factors for disease. However, challenges arise when trying to quantify the health effects of complex exposure mixtures. Analytical challenges include dealing with high dimensionality, studying the combined effects of these exposures and their interactions, integrating causal pathways, and integrating high-throughput omics layers. To tackle these challenges, the Barcelona Institute for Global Health (ISGlobal) held a data challenge event open to researchers from all over the world and from all expertises. Analysts had a chance to compete and apply state-of-the-art methods on a common partially simulated exposome dataset (based on real case data from the HELIX project) with multiple correlated exposure variables (P > 100 exposure variables) arising from general and personal environments at different time points, biological molecular data (multi-omics: DNA methylation, gene expression, proteins, metabolomics) and multiple clinical phenotypes in 1301 mother–child pairs. Most of the methods presented included feature selection or feature reduction to deal with the high dimensionality of the exposome dataset. Several approaches explicitly searched for combined effects of exposures and/or their interactions using linear index models or response surface methods, including Bayesian methods. Other methods dealt with the multi-omics dataset in mediation analyses using multiple-step approaches. Here we discuss features of the statistical models used and provide the data and codes used, so that analysts have examples of implementation and can learn how to use these methods. Overall, the exposome data challenge presented a unique opportunity for researchers from different disciplines to create and share state-of-the-art analytical methods, setting a new standard for open science in the exposome and environmental health field.
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