| 1. |
- Wennerberg, Ann, et al.
(författare)
-
Implant coatings: New modalities for increased osseointegration
- 2013
-
Ingår i: American Journal of Dentistry. - : Mosher & Linder. - 0894-8275. ; 26:2, s. 105-112
-
Forskningsöversikt (refereegranskat)abstract
- Purpose: To present new techniques for implant coatings, biological tissue response to them, and, if applicable, clinical outcome. Methods: A search for publications was done in PubMed using search words such as coated dental implants, clinical outcome, dental implant coatings and combinations thereof. Further, a manual search was done. 216 papers were found; the selection was directed towards in vivo investigations. Results: Several different coatings are described in the literature, many of them with the purpose to be bioactive. Such surface coatings include hydroxyapatite, bioglass, proteins, polysaccharides and drugs. The majority of the publications are evaluations in vitro; most of the in vivo studies are directed to implant incorporation in bone. Rather few exist that use a coat to promote soft tissue adhesion or prevention of infection.
|
|
| 2. |
- Abrahamsson, Peter, et al.
(författare)
-
Vertical bone augmentation with titanium granule blocks in rabbit calvaria
- 2017
-
Ingår i: Clinical and Experimental Dental Research. - : Wiley Open Access. - 2057-4347. ; 3:3, s. 100-106
-
Tidskriftsartikel (refereegranskat)abstract
- To determine whether it is possible to vertically augment bone utilizing a block graft from compressed titanium granules mainly used previously for contained bone defects and to determine whether there exists a difference in osteoconductive properties between the white and the grey granules. In 11 rabbits, 4 titanium blocks were inserted on each rabbit's skull bone according to a randomized scheme. These blocks were made from standardized compressed titanium granules. Type A: PTG grey, small granules (Pourus Titanium Granules, Tigran, Malmo, Sweden); Type B: PTG grey, large granules; Type C: PTG white, small granules; Type D: PTG white large granules. After 12 weeks, the animals were sacrificed and specimens were collected for histology and mu CT scanning. From both the mu CT and histology, it can be said that bone formation was successfully achieved for all groups, and the granules maintained their volume. The histomorphometric BA (bone area) evaluation in the entire grafted area presented that there were no statistical differences between all groups tested. The lowest 1/4 BA in contact with the rabbit skull presented that groups A and C presented the highest mean BA, and group A presented significantly higher BA than that of group D (p = 0,049). No significant differences were noted between groups A, B and C. Within the limitation of this study, no differences were noted between small white or grey PTG blocks. The large granules presented less bone ingrowth area compared to the small granules and this trend was regardless of the different PTG types. The entire grafted area was not filled with new bone suggesting that bone migration occurred mostly from the existing cortical bone side suggesting contact osteogenesis.
|
|
| 3. |
- Albrektsson, Tomas, 1945, et al.
(författare)
-
Overview of surface Microtopography/Chemistry/Physics/Nano-roughness
- 2015
-
Ingår i: Implant Surfaces and their Biological and Clinical Impact. - Berlin, Heidelberg : Springer. - 9783662453797 ; , s. 7-12
-
Bokkapitel (refereegranskat)abstract
- The implant surface has since long been recognised as important for the host response to oral implants. When the implant is inserted in the body, blood will immediately cover the implant surface. Different surface properties may trigger proteins and signalling system to enhance and speed up the healing process. The implant surface can be altered with respect to topography, chemistry, physics and mechanical properties. In particular, so far the surface topography and chemistry have gained the greatest interest from researchers and manufacturers of oral implants. © Springer-Verlag Berlin Heidelberg 2015.
|
|
| 4. |
- Alenezi, Ali, et al.
(författare)
-
Characteristics of 2 Different Commercially Available Implants with or without Nanotopography
- 2013
-
Ingår i: International Journal of Dentistry. - : Hindawi Limited. - 1687-8736 .- 1687-8728. ; 2013:Art. no. 769768
-
Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to assess histologically and histomorphometrically the early bone forming properties after 3 weeks for 2 commercially available implants, one supposedly possessing nanotopography and one without, in a rabbit femur model. Twenty-four implants divided equally into 2 groups were utilized in this study. The first group (P-I MICRO+NANO) was a titanium oxide (TiO2) microblasted and noble gas ion bombarded surface while the second group (Ospol) was anodic oxidized surface with calcium and phosphate incorporation. The implants were placed in the rabbit femur unicortically and were allowed to heal for 3 weeks. After euthanasia, the samples were subjected to histologic sectioning and bone-implant contact and bone area were evaluated histomorphometrically under an optical microscope. The histomorphometric evaluation presented that the P-I MICRO+NANO implants demonstrated significantly higher new bone formation as compared to the Ospol implants. Within the limitations of this study, the results suggested that nanostructures presented significantly higher bone formation after 3 weeks in vivo, and the effect of chemistry was limited, which is indicative that nanotopography is effective at early healing periods.
|
|
| 5. |
- Alenezi, Ali, et al.
(författare)
-
Controlled release of Clarithromycin from PLGA microspheres enhances bone regeneration in rabbit calvaria defects
- 2017
-
Ingår i: Journal of Biomedical Materials Research. Part B - Applied biomaterials. - : John Wiley & Sons. - 1552-4973 .- 1552-4981. ; 106:1, s. 201-208
-
Tidskriftsartikel (refereegranskat)abstract
- Purpose: To evaluate the controlled release effect of Clarithromycin loaded in PLGA microspheres in a rabbit calvaria defect model. Methods: Clarithromycin-loaded PLGA microspheres (MSPs) were formulated by modified O/W single emulsion/solvent evaporation method. After characterization, in vivo animal experiment was conducted. Four critical size bone defects were created in the calvaria of New Zealand White rabbits (n=21, n=7/time point). The bone defects were randomly designated to 4 groups: Group 1: No augmentation (sham), Group 2: beta-Tricalcium phosphate (β-TCP), Group 3: beta-Tricalcium phosphate (β-TCP) with 0.12 µg clarithromycin, and Group 4: beta-Tricalcium phosphate (β-TCP) with 6.12 µg PLGA microspheres (loaded with 0.12 µg clarithromycin). After 2, 4 and 12 weeks of healing, the levels of bone regeneration were evaluated using micro- computed tomography and histology. Results: The average size of the PLGA microspheres was 26.38 μm that showed 94% encapsulation efficacy with clarithromycin. Clarithromycin release from PLGA microspheres revealed sustained release for around 4 weeks with approximately 50% release of clarithromycin during the first week. In the histological analysis, new bone formation was evident at 2 and 4 weeks of healing in all groups and bone formation increased as a function of healing time in vivo. At 12 weeks, Group 4 showed significantly higher amount of newly formed bone compared to Group 1 (p=0,002). Moreover, during the micro CT exam, Group 4 expressed significantly higher bone formation compared to Group 1 at all time points tested (p=0.00, 0.014, and 0.002 in 2, 4, and 12 weeks, respectively). Conclusions: PLGA microspheres demonstrated initial burst release of clarithromycin followed by a sustained release profile. The in vivo findings showed that β-TCP with clarithromycin-loaded microspheres can enhance bone formation in bone defects.
|
|
| 6. |
- Anchieta, Rodolfo B., et al.
(författare)
-
Mechanical Property Assessment of Bone Healing around a Titanium-Zirconium Alloy Dental Implant
- 2014
-
Ingår i: Clinical Implant Dentistry and Related Research. - : John Wiley & Sons. - 1523-0899 .- 1708-8208. ; 16:6, s. 913-919
-
Tidskriftsartikel (refereegranskat)abstract
- BackgroundIt has been reported that titanium-zirconium alloy with 13-17% zirconium (TiZr1317) implants show higher biomechanical stability and bone area percentage relative to commercially pure titanium (cpTi) grade 4 fixtures. PurposeThis study aimed to determine whether the higher stability for TiZr1317 implants is associated with higher mechanical properties of remodeling bone in the areas around the implants. Materials and MethodsThis study utilized 36 implants (n=18: TiZr1317, n=18: cpTi), which were placed in the healed ridges of the mandibular premolar and first molar of 12 mini pigs (n=3 implants/animal). After 4 weeks in vivo, the samples were retrieved, and resin-embedded histologic sections of approximately 100m in thickness were prepared. In order to determine the nanomechanical properties, nanoindentation (n=30 tests/specimen) was performed on the bone tissue of the sections under wet conditions with maximum load of 300N (loading rate: 60N/s). ResultsThe mean (standard deviation) elastic modulus (E) and hardness (H) for the TiZr1317 group were 2.73 +/- 0.50GPa and 0.116 +/- 0.017GPa, respectively. For the cpTi group, values were 2.68 +/- 0.51GPa and 0.110 +/- 0.017GPa for E and H, respectively. Although slightly higher mechanical properties values were observed for the TiZr1317 implants relative to the cpTi for both elastic modulus and hardness, these differences were not significant (E=p>0.75; H=p>0.59). ConclusionsThe titanium-zirconium alloy used in this study presented similar degrees of nanomechanical properties to that of the cpTi implants.
|
|
| 7. |
- Anders, Halldin, et al.
(författare)
-
Improved osseointegration and interlocking capacity with dual acid treated implants: a rabbit study.
- 2016
-
Ingår i: Clinical Oral Implants Research. - : Wiley. - 0905-7161 .- 1600-0501. ; 27, s. 22-30
-
Tidskriftsartikel (refereegranskat)abstract
- Aim To investigate how osseointegration is affected by different nano- and microstructures. The hypothesis was that the surface structure created by dual acid treatment (AT-1), applied on a reduced topography, might achieve equivalent biomechanical performance as a rougher surface treated with hydrofluoric acid (HF). Materials and methods In a preclinical rabbit study, three groups (I, II, and III) comprised of test and control implants were inserted in 30 rabbits. The microstructures of the test implants were either produced by blasting with coarse (I) or fine (II) titanium particles or remained turned (III). All test implants were thereafter treated with AT-1 resulting in three different test surfaces. The microstructure of the control implants was produced by blasting with coarse titanium particles thereafter treated with HF. The surface topography was characterized by interferometry. Biomechanical (removal torque) and histomorphometric (bone–implant contact; bone area) performances were measured after 4 or 12 weeks of healing. Results Removal torque measurement demonstrated that test implants in group I had an enhanced biomechanical performance compared to that of the control despite similar surface roughness value (Sa). At 4 weeks of healing, group II test implants showed equivalent biomechanical performance to that of the control, despite a decreased Sa value. Group III test implants showed decreased biomechanical performance to that of the control. Conclusions: The results of the present study suggest that nano- and microstructure alteration by AT-1 on a blasted implant might enhance the initial biomechanical performance, while for longer healing time, the surface interlocking capacity seems to be more important.
|
|
| 8. |
- Anderud, Jonas, et al.
(författare)
-
Guided bone augmentation using a ceramic space-maintaining device
- 2014
-
Ingår i: Oral surgery, oral medicine, oral pathology and oral radiology. - : Elsevier. - 2212-4403 .- 2212-4411. ; 118:5, s. 532-538
-
Tidskriftsartikel (refereegranskat)abstract
- Objective. The purpose of this study was to evaluate 3-dimensionally whether vertical bone augmentation can be achieved using a hollow hydroxyapatite space-maintaining device in a rabbit calvarial model. Furthermore, different inner surface topographies, different permeabilities, and different porosities of the ceramic were tested to determine the optimal conditions for bone regeneration.
|
|
| 9. |
- Anderud, Jonas, et al.
(författare)
-
Guided bone augmentation using ceramic space-maintaining devices : The impact of chemistry
- 2015
-
Ingår i: Clinical, Cosmetic and Investigational Dentistry. - : Nakladatelstvi Lidove noviny. - 1179-1357. ; 7, s. 45-53
-
Tidskriftsartikel (refereegranskat)abstract
- The purpose of the study was to evaluate histologically, whether vertical bone augmentation can be achieved using a hollow ceramic space maintaining device in a rabbit calvaria model. Furthermore, the chemistry of microporous hydroxyapatite and zirconia were tested to determine which of these two ceramics are most suitable for guided bone generation. 24 hollow domes in two different ceramic materials were placed subperiosteal on rabbit skull bone. The rabbits were sacrificed after 12 weeks and the histology results were analyzed regarding bone-to-material contact and volume of newly formed bone. The results suggest that the effect of the microporous structure of hydroxyapatite seems to facilitate for the bone cells to adhere to the material and that zirconia enhance a slightly larger volume of newly formed bone. In conclusion, the results of the current study demonstrated that ceramic space maintaining devices permits new bone formation and osteoconduction within the dome.
|
|
| 10. |
- Anderud, Jonas, et al.
(författare)
-
The impact of surface roughness and permeability in hydroxyapatite bone regeneration membranes
- 2015
-
Ingår i: Clinical Oral Implants Research. - : Blackwell Munksgaard. - 0905-7161 .- 1600-0501. ; 27:8, s. 1047-1054
-
Tidskriftsartikel (refereegranskat)abstract
- Background: One of the crucial aspects in guided bone regeneration is the space maintenance. This is normally created by a membrane, which should primarily be accepted by the surrounding tissues without causing any adverse reactions. The impact of surface topography, biological acceptance as well as permeability of these membranes has been carefully discussed in the literature. Purpose: The purpose of this study was to evaluate histologically the bone forming properties inside of hollow hydroxyapatite space-maintaining devices with different inner surfaces and different permeabilities in an animal calvaria model in vivo. Materials and methods: A total of 36 hollow domes with three different designs made of hydroxyapatite were surgically attached to the skulls of rabbits. Group 1 had a moderately rough inner surface. Group 2 had a smooth inner surface. Group 3 had the same properties as Group 1 but had macroscopic holes on the top. The domes were left to heal for 12 weeks and were then processed for undecalcified ground sectioning. Histological evaluations were performed using a light microscope and scanning electron microscopy. The bone-implant contact (BIC) percentage along the device was calculated. Results: The median percentage of BIC was higher for Group 1 compared with Group 2 (P = 0.004). Group 1 produced a larger median BIC compared with Group 3 (P < 0.0001). Conclusions: Within the limits of this preclinical study, these findings suggest that a moderately rough inner surface of a ceramic membrane along with a non-permeable device produces more bone than a smooth inner surface.
|
|
