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- Koblischka, M. R., et al.
(författare)
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Magneto-optic imaging of flux penetration into an artificially granular high-Tc superconductor
- 1999
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Ingår i: Advances in Superconductivity XI. Proceedings of the 11th International Symposium on Superconductivity (ISS'98). - 4431702563 ; 2, s. 693-696
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- A YBa2Cu3O7- (YBCO) thin film is patterned into a hexagonal close packed lattice of disks which are touching each other at the circumferences in order to enable the flow of an intergranular current. Such a sample was suggested by Koblischka et al. [Appl. Phys. Lett 70, 514 (1997)] as a model for a layered granular structure like in a Bi2Sr2Ca2Cu3O10- tape. Magnetization measurements reveal an anomalous position of the low field peak (central peak) similar to the tapes. Magneto-optic imaging is employed to visualize the local field distributions
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| 3. |
- Koblishka, M. R., et al.
(författare)
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Flux penetration into an artificially granular high-Tc superconductor
- 1999
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Ingår i: Physical Review B. - 2469-9969 .- 2469-9950. ; 59, s. 12114-20
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Tidskriftsartikel (refereegranskat)abstract
- A YBa2Cu3O7- thin film is patterned into a hexagonal close-packed lattice of disks (2r=50 m) which are touching each other at the circumferences in order to enable the flow of an intergranular current. Such a sample was suggested by Koblischka et al. [Appl. Phys. Lett. 70, 514 (1997)] as a model for a layered granular structure like in a (Pb,Bi)2Sr2Ca2Cu3O10+ (Bi-2223) tape. The magnetization measurements reveal an anomalous position of the low-field peak (central peak) similar to Bi-2223 tapes. Magneto-optic imaging is employed to visualize the local-field distributions. At low magnification, the flux patterns in the intergranular area between the disks are observed. The observations at high magnification reveal the flux penetration and pinning within the disks. It is shown that such samples may serve as model samples for granular high-Tc superconductors
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| 4. |
- Acerbo, E, et al.
(författare)
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Non-thermal Electroporation Ablation of Epileptogenic Zones Stops Seizures in Mice While Providing Reduced Vascular Damage and Accelerated Tissue Recovery
- 2021
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Ingår i: Frontiers in behavioral neuroscience. - : Frontiers Media SA. - 1662-5153. ; 15, s. 774999-
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Tidskriftsartikel (refereegranskat)abstract
- In epilepsy, the most frequent surgical procedure is the resection of brain tissue in the temporal lobe, with seizure-free outcomes in approximately two-thirds of cases. However, consequences of surgery can vary strongly depending on the brain region targeted for removal, as surgical morbidity and collateral damage can lead to significant complications, particularly when bleeding and swelling are located near delicate functional cortical regions. Although focal thermal ablations are well-explored in epilepsy as a minimally invasive approach, hemorrhage and edema can be a consequence as the blood-brain barrier is still disrupted. Non-thermal irreversible electroporation (NTIRE), common in many other medical tissue ablations outside the brain, is a relatively unexplored method for the ablation of neural tissue, and has never been reported as a means for ablation of brain tissue in the context of epilepsy. Here, we present a detailed visualization of non-thermal ablation of neural tissue in mice and report that NTIRE successfully ablates epileptic foci in mice, resulting in seizure-freedom, while causing significantly less hemorrhage and edema compared to conventional thermal ablation. The NTIRE approach to ablation preserves the blood-brain barrier while pathological circuits in the same region are destroyed. Additionally, we see the reinnervation of fibers into ablated brain regions from neighboring areas as early as day 3 after ablation. Our evidence demonstrates that NTIRE could be utilized as a precise tool for the ablation of surgically challenging epileptogenic zones in patients where the risk of complications and hemorrhage is high, allowing not only reduced tissue damage but potentially accelerated recovery as vessels and extracellular matrix remain intact at the point of ablation.
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| 5. |
- Botzanowski, Boris, et al.
(författare)
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Noninvasive Stimulation of Peripheral Nerves using Temporally-Interfering Electrical Fields
- 2022
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Ingår i: Advanced Healthcare Materials. - : Wiley. - 2192-2640 .- 2192-2659. ; 11:17
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Tidskriftsartikel (refereegranskat)abstract
- Electrical stimulation of peripheral nerves is a cornerstone of bioelectronic medicine. Effective ways to accomplish peripheral nerve stimulation (PNS) noninvasively without surgically implanted devices are enabling for fundamental research and clinical translation. Here, it is demonstrated how relatively high-frequency sine-wave carriers (3 kHz) emitted by two pairs of cutaneous electrodes can temporally interfere at deep peripheral nerve targets. The effective stimulation frequency is equal to the offset frequency (0.5 - 4 Hz) between the two carriers. This principle of temporal interference nerve stimulation (TINS) in vivo using the murine sciatic nerve model is validated. Effective actuation is delivered at significantly lower current amplitudes than standard transcutaneous electrical stimulation. Further, how flexible and conformable on-skin multielectrode arrays can facilitate precise alignment of TINS onto a nerve is demonstrated. This method is simple, relying on the repurposing of existing clinically-approved hardware. TINS opens the possibility of precise noninvasive stimulation with depth and efficiency previously impossible with transcutaneous techniques.
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