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- Kjellman, M., et al.
(författare)
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A Plasma Protein Biomarker Strategy for Detection of Small Intestinal Neuroendocrine Tumors
- 2021
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Ingår i: Neuroendocrinology. - : S. Karger AG. - 0028-3835 .- 1423-0194. ; 111:9, s. 840-849
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Tidskriftsartikel (refereegranskat)abstract
- Background: Small intestinal neuroendocrine tumors (SI-NETs) are difficult to diagnose in the early stage of disease. Current blood biomarkers such as chromogranin A (CgA) and 5-hydroxyindolacetic acid have low sensitivity (SEN) and specificity (SPE). This is a first preplanned interim analysis (Nordic non-interventional, prospective, exploratory, EXPLAIN study [NCT02630654]). Its objective is to investigate if a plasma protein multi-biomarker strategy can improve diagnostic accuracy (ACC) in SI-NETs. Methods: At the time of diagnosis, before any disease-specific treatment was initiated, blood was collected from patients with advanced SI-NETs and 92 putative cancer-related plasma proteins from 135 patients were analyzed and compared with the results of age- and sex-matched controls (n = 143), using multiplex proximity extension assay and machine learning techniques. Results: Using a random forest model including 12 top ranked plasma proteins in patients with SI-NETs, the multi-biomarker strategy showed SEN and SPE of 89 and 91%, respectively, with negative predictive value (NPV) and positive predictive value (PPV) of 90 and 91%, respectively, to identify patients with regional or metastatic disease with an area under the receiver operator characteristic curve (AUROC) of 99%. In 30 patients with normal CgA concentrations, the model provided a diagnostic SPE of 98%, SEN of 56%, and NPV 90%, PPV of 90%, and AUROC 97%, regardless of proton pump inhibitor intake. Conclusion: This interim analysis demonstrates that a multi-biomarker/machine learning strategy improves diagnostic ACC of patients with SI-NET at the time of diagnosis, especially in patients with normal CgA levels. The results indicate that this multi-biomarker strategy can be useful for early detection of SI-NETs at presentation and conceivably detect recurrence after radical primary resection.
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| 2. |
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| 3. |
- Abish, Aynur, 1982-
(författare)
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Modality in Kazakh as spoken in China
- 2014
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This is a comprehensive study on expressions of modality in one of the largest Turkic languages, Kazakh, as it is spoken in China. Kazakh is the official language of the Republic of Kazakhstan and is furthermore spoken by about one and a half million people in China in the Xinjiang Uyghur Autonomous Region and in Aksai Kazakh Autonomous County in Gansu Province.The method employed is empirical, i.e. data-oriented. The modal expressions in Kazakh are analyzed in a theoretical framework essentially based on the works of Lars Johanson. The framework defines semantic notions of modality from a functional and typological perspective. The modal volition, deontic evaluation, and epistemic evaluation express attitudes towards the propositional content and are conveyed in Kazakh by grammaticalized moods, particles and lexical devices. All these categories are treated in detail, and ample examples of their different usages are provided with interlinear annotation. The Kazakh expressions are compared with corresponding ones used in other Turkic languages. Contact influences of Uyghur and Chinese are also dealt with.The data used in this study include texts recorded by the author in 20102012, mostly in the northern regions of Xinjiang, as well as written texts published in Kazakhstan and China. The written texts represent different genres: fiction, non-fiction, poetry and texts published on the Internet. Moreover, examples have been elicited from native speakers of Kazakh and Uyghur.The Appendix contains nine texts recorded by the author in the Kazakh-speaking regions of Xinjiang, China. These texts illustrate the use of many of the items treated in the study.
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| 4. |
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| 5. |
- Betsch, A, et al.
(författare)
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Observation of strong final-state effects in pi(+) production in pp collisions at 400 MeV
- 1999
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Ingår i: PHYSICS LETTERS B. - : ELSEVIER SCIENCE BV. - 0370-2693. ; 446:2, s. 179-184
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Tidskriftsartikel (refereegranskat)abstract
- Differential cross sections of the reactions pp --> d pi(+) and pp --> pn pi(+) have been measured at T-p = 400 MeV by detecting the charged ejectiles in the angular range 4 degrees less than or equal to Theta(Lab) less than or equal to 21 degrees. The de
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| 6. |
- Bilger, R, et al.
(författare)
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2 pi production in pp collisions close to threshold
- 2000
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Ingår i: NUCLEAR PHYSICS A. - : ELSEVIER SCIENCE BV. ; , s. 469C-472C
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Konferensbidrag (refereegranskat)abstract
- The reaction pp --> NN pi pi has been measured close to threshold in the energy range from 650 to 775 MeV using the PROMICE/WASA setup at CELSIUS. These data constitute the first exclusive high-statistics measurements of this reaction on a pure hydrogen t
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| 7. |
- Bilger, R, et al.
(författare)
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Cross sections of the pp -> pp pi(0) reaction between 310 and 425 MeV
- 2001
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Ingår i: NUCLEAR PHYSICS A. - : ELSEVIER SCIENCE BV. - 0375-9474. ; 693:3-4, s. 633-662
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Tidskriftsartikel (refereegranskat)abstract
- Extensive kinematically complete measurements of the pp --> pp pi (0) reaction have been made at six beam energies: 310, 320, 340, 360, 400, and 425 MeV. Angles and energies of both final-state protons are extracted from the forward detector system of the
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| 8. |
- Bilger, R, et al.
(författare)
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Spectator tagging in quasi-free pn-reactions on deuterium at PROMICE/WASA, CELSIUS
- 2000
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Ingår i: Nuclear Physics A. - : Elsevier Science B.V. Holland. ; , s. 1053c-1056c
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Konferensbidrag (refereegranskat)abstract
- A set of silicon detectors has been added to the PROMICE/WASA (P/W) experiment at CELSIUS. These detectors have been used for spectator-proton tagging in proton deuteron collisions to investigate proton-neutron reactions at intermediate energies. The perf
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