| 1. |
- Engström, Gunnar, et al.
(författare)
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The Swedish CArdioPulmonary BioImage Study : objectives and design
- 2015
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Ingår i: Journal of Internal Medicine. - : Wiley. - 0954-6820 .- 1365-2796. ; 278:6, s. 645-659
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Tidskriftsartikel (refereegranskat)abstract
- Cardiopulmonary diseases are major causes of death worldwide, but currently recommended strategies for diagnosis and prevention may be outdated because of recent changes in risk factor patterns. The Swedish CArdioPulmonarybioImage Study (SCAPIS) combines the use of new imaging technologies, advances in large-scale 'omics' and epidemiological analyses to extensively characterize a Swedish cohort of 30 000 men and women aged between 50 and 64 years. The information obtained will be used to improve risk prediction of cardiopulmonary diseases and optimize the ability to study disease mechanisms. A comprehensive pilot study in 1111 individuals, which was completed in 2012, demonstrated the feasibility and financial and ethical consequences of SCAPIS. Recruitment to the national, multicentre study has recently started.
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| 2. |
- Johansson, Carl-Johan, et al.
(författare)
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Sågverksnytt nr 1
- 2013
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Rapport (övrigt vetenskapligt/konstnärligt)
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| 3. |
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| 4. |
- Ekblom Bak, Elin, 1981-, et al.
(författare)
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Accelerometer derived physical activity and subclinical coronary and carotid atherosclerosis : cross-sectional analyses in 22 703 middle-aged men and women in the SCAPIS study
- 2023
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Ingår i: BMJ Open. - : BMJ Publishing Group Ltd. - 2044-6055. ; 13:11
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: The aim included investigation of the associations between sedentary (SED), low-intensity physical activity (LIPA), moderate-to-vigorous intensity PA (MVPA) and the prevalence of subclinical atherosclerosis in both coronaries and carotids and the estimated difference in prevalence by theoretical reallocation of time in different PA behaviours.DESIGN: Cross-sectional.SETTING: Multisite study at university hospitals.PARTICIPANTS: A total of 22 670 participants without cardiovascular disease (51% women, 57.4 years, SD 4.3) from the population-based Swedish CArdioPulmonary bioImage study were included. SED, LIPA and MVPA were assessed by hip-worn accelerometer.PRIMARY AND SECONDARY OUTCOMES: Any and significant subclinical coronary atherosclerosis (CA), Coronary Artery Calcium Score (CACS) and carotid atherosclerosis (CarA) were derived from imaging data from coronary CT angiography and carotid ultrasound.RESULTS: High daily SED (>70% ≈10.5 hours/day) associated with a higher OR 1.44 (95% CI 1.09 to 1.91), for significant CA, and with lower OR 0.77 (95% CI 0.63 to 0.95), for significant CarA. High LIPA (>55% ≈8 hours/day) associated with lower OR for significant CA 0.70 (95% CI 0.51 to 0.96), and CACS, 0.71 (95% CI 0.51 to 0.97), but with higher OR for CarA 1.41 (95% CI 1.12 to 1.76). MVPA above reference level, >2% ≈20 min/day, associated with lower OR for significant CA (OR range 0.61-0.67), CACS (OR range 0.71-0.75) and CarA (OR range 0.72-0.79). Theoretical replacement of 30 min of SED into an equal amount of MVPA associated with lower OR for significant CA, especially in participants with high SED 0.84 (95% CI 0.76 to 0.96) or low MVPA 0.51 (0.36 to 0.73).CONCLUSIONS: MVPA was associated with a lower risk for significant atherosclerosis in both coronaries and carotids, while the association varied in strength and direction for SED and LIPA, respectively. If causal, clinical implications include avoiding high levels of daily SED and low levels of MVPA to reduce the risk of developing significant subclinical atherosclerosis.
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| 5. |
- Johansson, Bengt, et al.
(författare)
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A Physical Two-Zone NOx Model Intended for Embedded Implementation
- 2009
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Ingår i: SAE Technical Papers. - 400 Commonwealth Drive, Warrendale, PA, United States : SAE International. - 0148-7191.
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Konferensbidrag (refereegranskat)abstract
- This paper offers a two-zone NOx model suitable for vehicle on-board, on-line implementation. Similar NOx modeling attempts have previously been undertaken. The hereby suggested method does however offer clear and important benefits over the previously methods, utilizing a significantly different method to handle temperature calculations within the (two) different zones avoiding iterative computation. The new method significantly improves calculation speed and, most important of all, reduces implementation complexity while still maintaining reasonable accuracy and the physical interpretation of earlier suggested methods. The equations commonly used to compute NOx emissions is also rewritten in order to suit a two-zone NOx model. An algorithm which can be used to compute NOx emissions is presented and the intended contribution of the paper is a NOx model, implementation feasible for an embedded system, e.g. embedded processor or embedded electronic hardware (FPGA). For that purpose parts of the algorithm can be pre-computed and stored in tables allowing significant acceleration of the computation.
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| 6. |
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| 7. |
- Peterson, Anders, Docent, 1976-, et al.
(författare)
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Deliverable D 3.1: Analysis of the gap between daily timetable and operational traffic
- 2019
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Fr8Rail II/Work-Package 3 Real-time network management and improved methods for timetable planning addresses the problem to improve capacity and punctuality in the railway system by developing concepts and methods for tactical planning and operational traffic. In this report the state-of-the-art has been summarised.The aim of the project is to:Propose concepts and methods that improve the annual and short-term timetable planning.Demonstrate how the proposed timetable planning concepts improve the prerequisites for real-time network management.Develop methods and tools that can reduce inefficiencies in real time network management.An important aspect is to improve the coordination between yards/terminals and the line network, and between Infrastructure Manager, Yard Managers, and freight Rail Undertakings.We motivate our research by the current situation in Sweden, which is characterised by low on-time performance for freight trains, dense and heterogenous traffic on the major railway lines, and a rigid annual timetabling process, which is non-suitable for short-term changes. We believe that better tools for network planning and management on tactical and operational level can help to connect planning and operational processes.Aiming for improvements of the operational traffic, there is a need for systematic development of methods applied at several planning horizons, based on both simulation and optimization techniques. Close to operation fast methods are needed, for example, based on meta-heuristics.The maintenance planning process and improvement potential have been described. This is a new piece of the puzzle and it is important to close the gap between timetable planning and operational traffic. The different planning processes at the Infrastructure Manager, the Rail Undertakings and the Maintenance Contractors should be aligned.When developing new approaches for computational decision-support tools for real-time network management, it is important — but very challenging — to evaluate and benchmark with existing software tools. We also observe that the research stream on computational decision-support and algorithm development for railway traffic management has not yet been sufficiently merged with the corresponding research stream focusing on aspects of human computer interaction.
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| 8. |
- Rutgersson, Carolin, et al.
(författare)
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Fluoroquinolones and qnr genes in sediment, water, soil, and human fecal flora in an environment polluted by manufacturing discharges
- 2014
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Ingår i: Environmental Science and Technology. - : American Chemical Society (ACS). - 0013-936X .- 1520-5851. ; 48:14, s. 7825-7832
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Tidskriftsartikel (refereegranskat)abstract
- There is increasing concern that environmental antibiotic pollution promotes transfer of resistance genes to the human microbiota. Here, fluoroquinolone-polluted river sediment, well water, irrigated farmland, and human fecal flora of local villagers within a pharmaceutical industrial region in India were analyzed for quinolone resistance (qnr) genes by quantitative PCR. Similar samples from Indian villages farther away from industrial areas, as well as fecal samples from Swedish study participants and river sediment from Sweden, were included for comparison. Fluoroquinolones were detected by MS/MS in well water and soil from all villages located within three km from industrially polluted waterways. Quinolone resistance genes were detected in 42% of well water, 7% of soil samples and in 100% and 18% of Indian and Swedish river sediments, respectively. High antibiotic concentrations in Indian sediment coincided with high abundances of qnr, whereas lower fluoroquinolone levels in well water and soil did not. We could not find support for an enrichment of qnr in fecal samples from people living in the fluoroquinolone-contaminated villages. However, as qnr was detected in 91% of all Indian fecal samples (24% of the Swedish) it suggests that the spread of qnr between people is currently a dominating transmission route.
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| 9. |
- Rutgersson, Carolin, 1983, et al.
(författare)
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Fluoroquinolones and qnr genes in sediment, well water, soil and human fecal flora in an Indian environment polluted by drug manufacturing
- 2014
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Ingår i: Environmental Science and Technology. - : American Chemical Society (ACS). - 0013-936X .- 1520-5851. ; 48:14
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Tidskriftsartikel (refereegranskat)abstract
- There is increasing concern that environmental antibiotic pollution promotes transfer of resistance genes to the human microbiota. Here, fluoroquinolone-polluted river sediment, well water, irrigated farmland, and human fecal flora of local villagers within a pharmaceutical industrial region in India were analyzed for quinolone resistance (qnr) genes by quantitative PCR. Similar samples from Indian villages farther away from industrial areas, as well as fecal samples from Swedish study participants and river sediment from Sweden, were included for comparison. Fluoroquinolones were detected by MS/MS in well water and soil from all villages located within three km from industrially polluted waterways. Quinolone resistance genes were detected in 42% of well water, 7% of soil samples and in 100% and 18% of Indian and Swedish river sediments, respectively. High antibiotic concentrations in Indian sediment coincided with high abundances of qnr, whereas lower fluoroquinolone levels in well water and soil did not. We could not find support for an enrichment of qnr in fecal samples from people living in the fluoroquinolone-contaminated villages. However, as qnr was detected in 91% of all Indian fecal samples (24% of the Swedish) it suggests that the spread of qnr between people is currently a dominating transmission route.
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| 10. |
- Sjöberg, Carl, et al.
(författare)
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Clinical evaluation of multi-atlas based segmentation of lymph node regions in head and neck and prostate cancer patients
- 2013
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Ingår i: Radiation Oncology. - : BioMed Central. - 1748-717X. ; 8, s. Article number: 229-
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Tidskriftsartikel (refereegranskat)abstract
- Background: Semi-automated segmentation using deformable registration of selected atlas cases consisting of expert segmented patient images has been proposed to facilitate the delineation of lymph node regions for three-dimensional conformal and intensity-modulated radiotherapy planning of head and neck and prostate tumours. Our aim is to investigate if fusion of multiple atlases will lead to clinical workload reductions and more accurate segmentation proposals compared to the use of a single atlas segmentation, due to a more complete representation of the anatomical variations. Methods: Atlases for lymph node regions were constructed using 11 head and neck patients and 15 prostate patients based on published recommendations for segmentations. A commercial registration software (Velocity AI) was used to create individual segmentations through deformable registration. Ten head and neck patients, and ten prostate patients, all different from the atlas patients, were randomly chosen for the study from retrospective data. Each patient was first delineated three times, (a) manually by a radiation oncologist, (b) automatically using a single atlas segmentation proposal from a chosen atlas and (c) automatically by fusing the atlas proposals from all cases in the database using the probabilistic weighting fusion algorithm. In a subsequent step a radiation oncologist corrected the segmentation proposals achieved from step (b) and (c) without using the result from method (a) as reference. The time spent for editing the segmentations was recorded separately for each method and for each individual structure. Finally, the Dice Similarity Coefficient and the volume of the structures were used to evaluate the similarity between the structures delineated with the different methods. Results: For the single atlas method, the time reduction compared to manual segmentation was 29% and 23% for head and neck and pelvis lymph nodes, respectively, while editing the fused atlas proposal resulted in time reductions of 49% and 34%. The average volume of the fused atlas proposals was only 74% of the manual segmentation for the head and neck cases and 82% for the prostate cases due to a blurring effect from the fusion process. After editing of the proposals the resulting volume differences were no longer statistically significant, although a slight influence by the proposals could be noticed since the average edited volume was still slightly smaller than the manual segmentation, 9% and 5%, respectively. Conclusions: Segmentation based on fusion of multiple atlases reduces the time needed for delineation of lymph node regions compared to the use of a single atlas segmentation. Even though the time saving is large, the quality of the segmentation is maintained compared to manual segmentation.
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