| 1. |
- Bakketeig, Elisiv, et al.
(författare)
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Deliberating the conditions for implementing the Barnahus model : Knowledge drawn from an institutional analysis
- 2024
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Ingår i: Justice and recovery for victimised children : Institutional tensions in Nordic and European Barnahus models - Institutional tensions in Nordic and European Barnahus models. - 9783031532320 - 9783031532337 ; , s. 249-277
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Bokkapitel (refereegranskat)abstract
- Referring to the PROMISE network’s European Barnahus quality standards, this concluding chapter further explores the institutional tensions identified in the previous chapters. Although these standards are important for securing the Barnahus model’s authenticity in the ongoing diffusion, they do not sufficiently address the possible tensions and dilemmas involved. We argue that if the Barnahus model is to reach its full potential, challenges must be identified in order to develop ways to solve them in relation to the various national systems where the model is implemented. Otherwise, the Barnahus model may not reach its full potential within different national contexts, since governments may use the model mainly as a symbol that something is being done instead of a source for more fundamental systemic changes.
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| 2. |
- Berndt, Sonja I., et al.
(författare)
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Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
- 2013
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:5, s. 501-U69
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Tidskriftsartikel (refereegranskat)abstract
- Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
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| 3. |
- Johansson, Susanna, et al.
(författare)
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Diffusion and translation of the Barnahus model through the lens of institutional tensions
- 2024
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Ingår i: Justice and recovery for victimised children : Institutional tensions in Nordic and European Barnahus models - Institutional tensions in Nordic and European Barnahus models. - 9783031532337 - 9783031532320 ; , s. 1-42
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Bokkapitel (refereegranskat)abstract
- Since the Barnahus model was first introduced in Iceland in 1998, it has spread to a number of European countries, both within and beyond the Nordic region. This introductory chapter has two main objectives: The first is to describe the further diffusion of the Barnahus model throughout Europe and to exemplify various translations at local levels; the second is to set the framework for the book by introducing the concepts of institutional tensions and logics. We introduce the concepts involved in understanding the Barnahus model in the light of its ongoing implementation within different institutional contexts and related to this book’s four main themes: (1) legal tensions, (2) organisational tensions, (3) professional-ethical tensions, and (4) balancing institutional tensions.
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| 4. |
- Johansson, Susanna, et al.
(författare)
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Implementing the Nordic Barnahus Model : Characteristics and Local Adaptions
- 2017. - 1
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Ingår i: Collaborating Against Child Abuse : Exploring the Nordic Barnahus Model - Exploring the Nordic Barnahus Model. - Cham : Springer International Publishing. - 9783319583877 - 9783319583884 ; , s. 1-31
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Bokkapitel (refereegranskat)abstract
- This chapter describes the background for, and implementation of, the Barnahus model within the Nordic countries. It highlights the core elements of the model and the specifics of the Nordic welfare state context relating to the child welfare and criminal justice systems. A contextual and comparative perspective is used to shed light on how the model is shaped by the legal and institutional context in which it has been implemented. Local adaptions of the Barnahus model, specific to each Nordic country, are also identified. Finally, the outline of the book, containing sixteen chapters divided into four broad themes, is presented.
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| 5. |
- Johansson, Susanna, et al.
(författare)
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Included on paper, excluded in practice: or vice versa? : Formal and actual target groups of Barnahus across jurisdictions
- 2024
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Ingår i: Justice and recovery for victimised children : Institutional tensions in Nordic and European Barnahus models - Institutional tensions in Nordic and European Barnahus models. - 9783031532337 - 9783031532320 ; , s. 167-192
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Bokkapitel (refereegranskat)abstract
- The ongoing diffusion and European standardisation of the Barnahus model has involved a general expansion of the Barnahus target group, and variations in terms of inclusion and exclusion of different groups of children, such as those who have experienced domestic violence and those who have exhibited sexually harmful behaviour. Based on policy documents, reports, standards, and regulations from Sweden, Norway, and the European policy level, this chapter analyses how the positioning of children—as aggrieved parties, vulnerable individuals, and family members—is manifested in Barnahus regulations and case processing across jurisdictions, using Sweden and Norway as in-depth cases. The chapter shows how the positioning of children affects who is granted access to Barnahus (and to which services) during the different stages of case processing.
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| 6. |
- Shungin, Dmitry, et al.
(författare)
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New genetic loci link adipose and insulin biology to body fat distribution.
- 2015
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 187-378
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Tidskriftsartikel (refereegranskat)abstract
- Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
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| 7. |
- Stefansen, Kari, et al.
(författare)
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Epilogue: The Barnahus Model : Potentials and Challenges in the Nordic Context and Beyond
- 2017. - 1
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Ingår i: Collaborating Against Child Abuse : Exploring the Nordic Barnahus Model - Exploring the Nordic Barnahus Model. - Cham : Springer International Publishing. - 9783319583884 - 9783319583877 ; , s. 331-352
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Bokkapitel (refereegranskat)abstract
- A key message from this chapter - and the book as such - is that the Nordic Barnahus model is a step in the right direction in terms of meeting victimised children's needs and legal rights, and that it could be recommended as a promising practice for other countries. At the same time, it is not a quick fix. In light of the book contributions, this chapter discusses the potentials and challenges of the Barnahus model in the Nordic context and beyond. It highlights the importance of the Nordic welfare state context for the implementation of the model and discusses the different modes of governance that have developed around it. The chapter further describes how the implementation of the Barnahus model has led to the development of a new institutional field - the Barnahus field - and a corresponding field of multidisciplinary research.
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| 8. |
- Stefansen, Kari, et al.
(författare)
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Institutional barriers to medical examinations in Barnahus
- 2024
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Ingår i: Justice and recovery for victimised children : Institutional tensions in Nordic and European Barnahus models - Institutional tensions in Nordic and European Barnahus models. - 9783031532337 - 9783031532320 ; , s. 87-112
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Bokkapitel (refereegranskat)abstract
- Although ensuring that victimised children receive timely medical health assessments is among the key aims of Barnahus, this goal has proven difficult to achieve in Norway, the empirical case examined in this chapter. Few children are offered a medical examination, and most examinations that are performed primarily serve a role in the “penal track” of the Barnahus model. Based on data from two national evaluation studies, we identify three types of institutional barriers that hamper the role of medical examinations in the “welfare track” of the model: established routines, regulatory issues, and a lack of resources. The concept of institutional inertia is helpful in understanding the institutional resistance towards change that often characterises the present situation.
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| 9. |
- Turcot, Valerie, et al.
(författare)
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Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
- 2018
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Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 50:1, s. 26-41
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from which pinpointing causal genes remains challenging. Here we combined data from 718,734 individuals to discover rare and low-frequency (minor allele frequency (MAF) < 5%) coding variants associated with BMI. We identified 14 coding variants in 13 genes, of which 8 variants were in genes (ZBTB7B, ACHE, RAPGEF3, RAB21, ZFHX3, ENTPD6, ZFR2 and ZNF169) newly implicated in human obesity, 2 variants were in genes (MC4R and KSR2) previously observed to be mutated in extreme obesity and 2 variants were in GIPR. The effect sizes of rare variants are similar to 10 times larger than those of common variants, with the largest effect observed in carriers of an MC4R mutation introducing a stop codon (p.Tyr35Ter, MAF = 0.01%), who weighed similar to 7 kg more than non-carriers. Pathway analyses based on the variants associated with BMI confirm enrichment of neuronal genes and provide new evidence for adipocyte and energy expenditure biology, widening the potential of genetically supported therapeutic targets in obesity.
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| 10. |
- Amundadottir, Laufey T., et al.
(författare)
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A common variant associated with prostate cancer in European and African populations
- 2006
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Ingår i: Nature Genetics. - DeCODE Genet, IS-101 Reykjavik, Iceland. Univ Iceland, Landspitali Hosp, Dept Pathol, IS-101 Reykjavik, Iceland. Univ Iceland, Landspitali Hosp, Dept Urol, IS-101 Reykjavik, Iceland. Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA. Orebro Univ Hosp, Dept Urol & Clin Med, Orebro, Sweden. Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17177 Stockholm, Sweden. Univ Michigan, Dept Urol, Ann Arbor, MI 48109 USA. Northwestern Univ, Feinberg Sch Med, Dept Urol, Chicago, IL 60611 USA. Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA. Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA. Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA. : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 38:6, s. 652-658
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Tidskriftsartikel (refereegranskat)abstract
- With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P = 2.7 x 10(-11)). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of approximately 8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of affected individuals and 30% of the population are carriers. This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry.
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