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| 2. |
- Rydberg Sterner, Therese, et al.
(författare)
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The Gothenburg H70 Birth cohort study 2014-16: design, methods and study population.
- 2019
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Ingår i: European journal of epidemiology. - : Springer Science and Business Media LLC. - 1573-7284 .- 0393-2990. ; 34:2, s. 191-209
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Tidskriftsartikel (refereegranskat)abstract
- To improve health care for older persons, we need to learn more about ageing, e.g. identify protective factors and early markers for diseases. The Gothenburg H70 Birth Cohort Studies (the H70 studies) are multidisciplinary epidemiological studies examining representative birth cohorts of older populations in Gothenburg, Sweden. So far, six birth cohorts of 70-year-olds have been examined over time, and examinations have been virtually identical between studies. This paper describes the study procedures for the baseline examination of the Birth cohort 1944, conducted in 2014-16. In this study, all men and women born 1944 on specific dates, and registered as residents in Gothenburg, were eligible for participation (n=1839). A total of 1203 (response rate 72.2%; 559 men and 644 women; mean age 70.5years) agreed to participate in the study. The study comprised sampling of blood and cerebrospinal fluid, psychiatric, cognitive, and physical health examinations, examinations of genetics and family history, use of medications, social factors, functional ability and disability, physical fitness and activity, body composition, lung function, audiological and ophthalmological examinations, diet, brain imaging, as well as a close informant interview, and qualitative studies. As in previous examinations, data collection serves as a basis for future longitudinal follow-up examinations. The research gained from the H70 studies has clinical relevance in relation to prevention, early diagnosis, clinical course, experience of illness, understanding pathogenesis and prognosis. Results will increase our understanding of ageing and inform service development, which may lead to enhanced quality of care for older persons.
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| 3. |
- Arndt, Tina, et al.
(författare)
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Spidroin N-terminal domain forms amyloid-like fibril based hydrogels and provides a protein immobilization platform
- 2022
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13
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Tidskriftsartikel (refereegranskat)abstract
- Recombinant spider silk proteins (spidroins) have multiple potential applications in development of novel biomaterials, but their multimodal and aggregation-prone nature have complicated production and straightforward applications. Here, we report that recombinant miniature spidroins, and importantly also the N-terminal domain (NT) on its own, rapidly form self-supporting and transparent hydrogels at 37 °C. The gelation is caused by NT α-helix to β-sheet conversion and formation of amyloid-like fibrils, and fusion proteins composed of NT and green fluorescent protein or purine nucleoside phosphorylase form hydrogels with intact functions of the fusion moieties. Our findings demonstrate that recombinant NT and fusion proteins give high expression yields and bestow attractive properties to hydrogels, e.g., transparency, cross-linker free gelation and straightforward immobilization of active proteins at high density.
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| 4. |
- Hauber, Ernst, et al.
(författare)
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Periglacial landscapes on Svalbard: Terrestrial analogs for cold-climate landforms on Mars
- 2011
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Ingår i: The Geological Society of America, Special Paper. - : Geological Society of America. ; 483
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Tidskriftsartikel (refereegranskat)abstract
- We present landforms on Svalbard (Norway) as terrestrial analogs for possible Martian periglacial surface features. While there are closer climatic analogs for Mars, e.g., the Antarctic Dry Valleys, Svalbard has unique advantages that make it a very useful study area. Svalbard is easily accessible and offers a periglacial landscape where many different landforms can be encountered in close spatial proximity. These landforms include thermal contraction cracks, slope stripes, rock glaciers, protalus ramparts, and pingos, all of which have close morphological analogs on Mars. The combination of remotesensing data, in particular images and digital elevation models, with field work is a promising approach in analog studies and facilitates acquisition of fi rst-hand experience with permafrost environments. Based on the morphological ambiguity of certain landforms such as pingos, we recommend that Martian cold-climate landforms should not be investigated in isolation, but as part of a landscape system in a geological context.
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| 5. |
- Hauber, Ernst, et al.
(författare)
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Svalbard (Norway) as a terrestrial analogue for Martian landforms: Results on
- 2009
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Ingår i: EPSC Abstracts. European Planetary Science Congress. ; 4, EPSC2009-772
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Konferensbidrag (refereegranskat)abstract
- Small alluvial fan-like landforms have been observed on Mars in association with recent gullies. Such fans are relatively small (km-scale) when compared to large alluvial fans on Mars, which can reach dimensions of tens of kilometers. The small fans are part of an erosion-transportsedimentation system (alcove-channel-apron). Morphologically very similar systems can be studied on Svalbard (Norway), which is a cold and dry polar desert and, therefore, a potentially useful terrestrial analogue for Mars` climate and climaterelated landforms. Here we give an update on our field work in summer 2008 and a simultaneous flight campaign with an airborne version (HRSCAX) of the High Resolution Stereo Camera (HRSC) onboard Mars Express. We also present very preliminary results from the field campaign in summer 2009.
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| 7. |
- Johansson, Lars-Olof, 1957, et al.
(författare)
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Goal conflicts in political decision making: a survey of municipality politicians' view of road pricing.
- 2004
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Ingår i: Environment & Planning C: Government & Policy. - 0263-774X. ; 21:4, s. 615-624
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Tidskriftsartikel (refereegranskat)abstract
- Investigates the existence of goal conflicts in political decision-making in the case of municipality politicians in Sweden on the issue of road pricing scheme. Goals of municipality politicians other than reducing car use; Possibility of failure in achieving environmental goals because of goal conflicts.
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| 9. |
- Johansson, Mathias, et al.
(författare)
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Effect of starch and fibre on faba bean protein gel characteristics
- 2022
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Ingår i: Food Hydrocolloids. - : Elsevier BV. - 0268-005X .- 1873-7137. ; 131
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Tidskriftsartikel (refereegranskat)abstract
- Faba bean is a promising alternative to soybean for production of protein-rich plant-based foods. Increased understanding of the gelling behaviour of non-soy legumes can facilitate development of novel plant-based foods based on other legumes, such as faba bean. A mixture design was used in this study to evaluate the effect of different proportions of protein, starch and fibre fractions extracted from faba beans on gelation properties, texture and microstructure of the resulting gels. Large deformation properties, in terms of fracture stress and fracture strain, decreased as fibre and/or starch replaced protein. In contrast, Young's modulus and storage modulus increased with substitution of the protein. Light microscopy revealed that for all gels, protein remained the continuous phase within the region studied (65–100% protein fraction, 0–35% starch fraction, 0–10% fibre fraction in total flour added). Swollen and deformed starch granules were distributed throughout the mixed gels with added starch. Leaked amylose aggregated on starch and fibre surfaces and in small cavities (<1 μm) throughout the protein network. No clear difference between samples in protein network structure was observed by scanning electron microscopy. The reduction in large deformation properties was tentatively attributed to inhomogeneities created by the added starch and fibre. The increase in small deformation properties was hypothesised to be affected by water adsorption and moisture stability through the starch and fibre, increasing the effective protein concentration in the surrounding matrix and enhancing the protein network, or potentially by starch granules and fibre particles acting as active fillers reinforcing the gel structure.
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| 10. |
- Johansson, Mathias, et al.
(författare)
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Gelation behaviour and gel properties of the 7S and 11S globulin protein fractions from faba bean (Vicia faba var. minor) at different NaCl concentrations
- 2023
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Ingår i: Food Hydrocolloids. - 0268-005X .- 1873-7137. ; 142
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Tidskriftsartikel (refereegranskat)abstract
- The 7S and 11S globulins, the main protein fractions found in legumes, may differ in functionality. This study evaluated gel formation and rheological and microstructural properties of gels formed from the 7S and 11S protein fractions of faba bean. The effect of adding sodium chloride (NaCl) was also investigated. In terms of rheological and mechanical properties, NaCl addition appeared to have an opposing effect on 7S and 11S gels. Gels formed from 7S showed increases in storage modulus and peak stress when NaCl was added, whereas gels formed from 11S showed decreases. Microstructural changes were observed only for 7S gels, for which addition of NaCl resulted in transition from a fine-stranded to a coarse-stranded gel network. The 11S gels showed a fine-stranded gel network at all NaCl concentrations investigated. Gels formed from a mixture of 7S and 11S (7S:11S ratio 3:7) showed similar rheological properties and microstructure as the 11S gels.
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